388 research outputs found
Our Experience with Maxillectomies: A Retrospective Decade Study
No full textABSTRACT
Objective
The aim of the study is to evaluate the age, sex, site of lesion, histopathological diagnosis, and recurrence rate of the maxillectomy patients.
Materials and methods
A retrospective study was done in 42 patients, who underwent maxillectomy for malignant growth of the nose and paranasal sinuses from 2006 to 2015 at our center.
Results
The most common age group is 55 to 65 years (73.8), with male predominance (66.7%). Among symptoms prevalent is nasal obstruction (47%). Maxillary sinus is the most common site of origin (61.9%). Squamous cell carcinoma is the most common histopathological diagnosis (52.4%) and recurrence rate is 16%.
Conclusion
Exact clearance, reconstruction, postoperative care, and perfect teamwork play a vital role. Thus, successful outcome of maxillectomy is multifactorial.
How to cite this article
Rajasekar MK, Mariappan V, Veerasigamani N. Our Experience with Maxillectomies: A Retrospective Decade Study. Clin Rhinol An Int J 2017;10(2):58-61.
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Multiple sulfatase deficiency is caused by mutations in the gene encoding the human Cα-Formylglycine generating enzyme
No full textCα-formylglycine (FGly) is the catalytic residue in the active site of eukaryotic sulfatases. It is posttranslationally generated from a cysteine in the endoplasmic reticulum. The genetic defect of FGly formation causes multiple sulfatase deficiency (MSD), a lysosomal storage disorder. We purified the FGly generating enzyme (FGE) and identified its gene and nine mutations in seven Mp. patients. In patient fibroblasts, the activity of sulfatases is partially restored by transduction of FGE encoding cDNA, but not by cDNA carrying an MSD mutation. The gene encoding FGE is highly conserved among pro- and eukaryotes and has a paralog of unknown function in vertebrates. FGE is localized in the endoplasmic reticulum and is predicted to have a tri-partite domain structure
Corrigendum to "European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2023 Guidelines” [Eur. Urol. 85 (2024) 17–31, (S0302283823030737), (10.1016/j.eururo.2023.08.016)]
No full textThe authors regret the oversight in the initially published version of this article, where the name of Prof. Paramananthan Mariappan, along with his affiliation to the Edinburgh Bladder Cancer Surgery (EBCS), Western General Hospital, at The University of Edinburgh, Edinburgh, United Kingdom, was inadvertently omitted from the author list. This has now been updated. The authors would like to apologise for any inconvenience caused
Multiple sulfatase deficiency is caused by mutations in the gene encoding the human C-alpha-formylglycine generating enzyme
No full textDierks T, Schmidt B, Borissenko LV, et al. Multiple sulfatase deficiency is caused by mutations in the gene encoding the human C-alpha-formylglycine generating enzyme. CELL. 2003;113(4):435-444.C-alpha-formylglycine (FGly) is the catalytic residue in the active site of eukaryotic sulfatases. It is posttranslationally generated from a cysteine in the endoplasmic reticulum. The genetic defect of FGly formation causes multiple sulfatase deficiency (MSD), a lysosomal storage disorder. We purified the FGly generating enzyme (FGE) and identified its gene and nine mutations in seven MSD patients. In patient fibroblasts, the activity of sulfatases is partially restored by transduction of FGE encoding cDNA, but not by cDNA carrying an MSD mutation. The gene encoding FGE is highly conserved among pro- and eukaryotes and has a paralog of unknown function in vertebrates. FGE is localized in the endoplasmic reticulum and is predicted to have a tripartite domain structure
Manufacturing Processes for Permanent Magnets: Part II—Bonding and Emerging Methods
No full textPermanent magnets produce magnetic fields and maintain the field even in the presence of an opposing magnetic field. They are widely used in electric machines, electronics, and medical devices. Part I reviews the conventional manufacturing processes for commercial magnets, including Nd-Fe-B, Sm-Co, alnico, and ferrite in cast and sintered forms. In Part II, bonding, emerging advanced manufacturing processes, as well as magnet recycling methods are briefly reviewed for their current status, challenges, and future directions.This article is published as Cui, Jun, John Ormerod, David S. Parker, Ryan Ott, Andriy Palasyuk, Scott McCall, Mariappan Parans Paranthaman et al. "Manufacturing Processes for Permanent Magnets: Part II—Bonding and Emerging Methods." JOM 74, no. 6 (2022): 2492-2506.
DOI: 10.1007/s11837-022-05188-1.
Copyright 2022 The Author(s).
Attribution 4.0 International (CC BY 4.0).
Posted with permission.
DOE Contract Number(s): AC05-00OR22725; AC02-07CH11358; AC52- 07NA27344
Electrochemical performance of spinel-type Ni doped ZnCo2O4 mesoporous rods as an electrode for supercapacitors
No full textSynthesis, characterization, bioactivity and antibacterial studies of silver doped calcium borosilicate glass-ceramics
No full textThermal stability of anisotropic bonded magnets prepared by additive manufacturing
No full textIn this research, anisotropic NdFeB + SmFeN hybrid and NdFeB bonded magnets are additively printed in a polyphenylene sulfide (PPS) polymer binder. Printed NdFeB + SmFeN PPS bonded magnets displayed excellent magnetic properties (Br [remanence] = 6.9 kG [0.69 T], Hcj [coercivity] = 8.3 kOe [660 kA/m], and BHmax [energy product] = 9.9 MGOe [79 kJ/m3]) with superior corrosion resistance and thermal stability. The anisotropic NdFeB bonded magnet shows a high coercivity of 14.6 kOe (1162 kA/m) with a BHmax of 8.7 MGOe (69 kJ/m3). The coercivity and remanence temperature coefficients for NdFeB + SmFeN hybrid bonded magnets are −0.10%/K and −0.46%/K, and for NdFeB bonded magnets are −0.14%/K and −0.53%/K in the range of 300–400 K, indicating that the hybrid bonded magnets are thermally stable. The average flux aging loss for hybrid magnets was also determined to be very stable over 2000 h at 448 K (175°C) in air with 2.04% compared to that of NdFeB magnets with 3.62%.This article is published as Gandha, Kinjal, Mariappan Parans Paranthaman, Haobo Wang, Xubo Liu, and Ikenna C. Nlebedim. "Thermal stability of anisotropic bonded magnets prepared by additive manufacturing." Journal of the American Ceramic Society 106, no. 1 (2023): 166-171.
DOI: 10.1111/jace.18609
Copyright 2022 The Author(s).
Attribution 4.0 International (CC BY 4.0).
Posted with permission.
DOE Contract Number(s): AC02-07CH11358; AC05-00OR22725
Social media and its impact during the Covid-19
No full textAbstract: The primary object of this study is to survey the impact of social media on Covid-19. Therefore, a lot of research has been conducted to determine how social media is being used during the Covid-19 pandemic. Since social media have become the only means of connecting people throughout the world during the Covid-19 pandemic, this paper explores the way social media are affecting people and how this affects the Covid-19 pandemic. To that end, structured questionnaires were distributed to 256 participants. In a questionnaire, the message of respondents has been included, along with their motivational and burden factors, which are evident in their use of social media during the Covid-19 pandemic. People experience emotional problems due to the Covid-19 pandemic and are forced to look after their dependents, while some have the chance to increase their income with social media use. This research contributed to our present understanding of the public's reactions to social media during the Covid-19 pandemic. Our study found that people used social media a lot during the Covid-19 pandemic. Therefore, we can minimize the difficulties they will encounter on social media, helping them use it easily.
Keywords: Social media, Covid-19 pandemic, Emotional, Public.
Title: Social media and its impact during the Covid-19
Author: Lee Zi Shin, Sun Li Ting, Dr. Logenthini Mariappan
International Journal of Recent Research in Social Sciences and Humanities (IJRRSSH)
ISSN 2349-7831
Vol. 10, Issue 1, January 2023 - March 2023
Page No: 51-62
Paper Publications
Website: www.paperpublications.org
Published Date: 17-March-2023
DOI: https://doi.org/10.5281/zenodo.7745015
Paper Download Link (Source)
https://www.paperpublications.org/upload/book/Social%20media%20and%20its%20impact%20during-17032023-3.pdfInternational Journal of Recent Research in Social Sciences and Humanities (IJRRSSH), ISSN 2349-7831, Paper Publications, Website: www.paperpublications.or
Obesogenic diet in aging mice disrupts gut microbe composition and alters neutrophil:lymphocyte ratio, leading to inflamed milieu in acute heart failure
No full textInternational audienceCalorie-dense obesogenic diet (OBD) is a prime risk factor for cardiovascular disease in aging. However, increasing age coupled with changes in the diet can affect the interaction of intestinal microbiota influencing the immune system, which can lead to chronic inflammation. How age and calorie-enriched OBD interact with microbial flora and impact leukocyte profiling is currently under investigated. Here, we tested the interorgan hypothesis to determine whether OBD in young and aging mice alters the gut microbe composition and the splenic leukocyte profile in acute heart failure (HF). Young (2-mo-old) and aging (18-mo-old) mice were supplemented with standard diet (STD, approximately 4% safflower oil diet) and OBD (10% safflower oil) for 2 mo and then subjected to coronary artery ligation to induce myocardial infarction. Fecal samples were collected pre- and post-diet intervention, and the microbial flora were analyzed using 16S variable region 4 rRNA gene DNA sequencing and Quantitative Insights Into Microbial Ecology informatics. The STD and OBD in aging mice resulted in an expansion of the genus Allobaculum in the fecal microbiota. However, we found a pathologic change in the neutrophil:lymphocyte ratio in aging mice in comparison with their young counterparts. Thus, calorie-enriched OBD dysregulated splenic leukocytes by decreasing immune-responsive F4/80(+) and CD169(+) macrophages in aging mice. OBD programmed neutrophil swarming with an increase in isoprostanoid levels, with dysregulation of lipoxygenases, cytokines, and metabolite-sensing receptor expression. In summary, calorie-dense OBD in aging mice disrupted the composition of the gut microbiome, which correlates with the development of integrative and system-wide nonresolving inflammation in acute HF.-Kain, V., Van Der Pol, W., Mariappan, N., Ahmad, A., Eipers, P., Gibson, D. L., Gladine, C., Vigor, C., Durand, T., Morrow, C., Halade, G. V. Obesogenic diet in aging mice disrupts gut microbe composition and alters neutrophil:lymphocyte ratio, leading to inflamed milieu in acute heart failure
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