1,721,145 research outputs found
The James V. Mangano Collection
Full text linkThe James V. Mangano Collection holds five boxes of records and ephemera of Mr. Mangano’s career as a Democratic District leader, and Administrative Supervisor at the Kings County State Supreme building. The collection contains correspondence, both professional and personal, memorandums and reports, along with press reports and memorabilia. It is organized into three series. The first series is Correspondence which is broken down into two sub-series, General and Monroe Dinner. The second series is the New York state Supreme Court Administration. The third series is called Special Topics. Brooklyn College Archives and Special Collections also holds two collections which are related to Mr. Mangano. These are the Brooklyn Democratic Party Papers and the Papers of John Rooney
Sorveglianza molecolare della resistenza ai derivati dell’artemisinina e ad altri antimalarici in isolati di Plasmodium falciparum africani
Full text linkL’introduzione della terapia combinata a base di artemisinina (artemisinin-based combination therapy, ACT) ha rappresentato una svolta epocale nella lotta contro la malaria da Plasmodium falciparum, riducendo drasticamente la morbilità e mortalità da questa causate. Purtroppo, la diffusione della resistenza di P. falciparum all'artemisinina nel Sud-Est Asiatico costituisce una reale minaccia per il controllo e l’eliminazione della malaria, poiché rischia di vanificare i successi raggiunti nell’ultimo decennio, soprattutto in termini di sopravvivenza infantile. Numerosi studi, condotti su isolati di P. falciparum provenienti dal Sud-Est Asiatico, hanno dimostrato che la resistenza all’artemisinina è strettamente legata alla presenza di polimorfismi a singolo nucleotide (SNPs) nel gene kelch 13 (k13). Alcuni di questi SNPs sono anche stati descritti in Africa, ma mai nessuno è stato correlato ad un’aumentata tolleranza o resistenza all'artemisinina (Ménard et al., 2016). La recente introduzione di strumenti di biologia molecolare di nuova generazione, volti alla rapida e precoce individuazione di parassiti resistenti, consente di perfezionare e rendere più accurate le strategie terapeutiche e profilattiche impiegate nei casi di malaria da P. falciparum. In questo lavoro di tesi, al fine di identificare la presenza di mutazioni puntiformi nel gene k13 di P. falciparum, sono stati analizzati, mediante PCR e sequenziamento diretto, 930 isolati di P. falciparum raccolti in quattro paesi africani nei quali la malaria continua a rappresentare un importante problema di salute pubblica: Camerun, Eritrea, Botswana, e Guinea Conakry. Per i campioni provenienti dal Camerun e dall’Eritrea, lo screening molecolare è stato effettuato tramite il sequenziamento di nuova generazione NGS, ovvero un sistema standardizzato di sorveglianza della farmaco-resistenza ad alto rendimento. Oltre all’analisi del gene Pfk13, è stata valutata l’eventuale presenza di mutazioni nei diversi geni marcatori di resistenza per gli antimalarici comunemente impiegati nelle combinazioni terapeutiche a base di artemisinina. Inoltre, in collaborazione con il CDC (Centre for Disease Control and Prevention) di Atlanta, è stato messo a punto un nuovo metodo di rilevazione dell’espressione del gene plasmepsina 2 di P. falciparum, coinvolto nella resistenza alla piperachina. I risultati dello studio di sorveglianza molecolare qui riportati non hanno evidenziato alcuna resistenza all'artemisinina. Tuttavia, per gli altri marcatori molecolari indagati, è stata identificata un’alta frequenza di varianti alleliche associate alla resistenza alle diverse classi di farmaci antimalarici. Questi risultati suggeriscono la forte necessità di effettuare una costante valutazione di efficacia terapeutica dei farmaci impiegati nel trattamento della malaria da P. falciparum, e un assiduo monitoraggio molecolare della farmaco-resistenza, al fine di sviluppare adeguate strategie di controllo e prevenzione della malaria
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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