3,000 research outputs found

    Pseudotumor cerebri e terapia dell’acne.

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    Si analizzano casi di pseudotumor cerebri farmaco-indotto in pazienti trattati per acne volgar

    Water transport between CNS compartments: functional and molecular interactions between aquaporins and ion channels

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    The physiological ability of the mammalian CNS to integrate peripheral stimuli and to convey information to the body is tightly regulated by its capacity to preserve the ion composition and volume of the perineuronal milieu. It is well known that astroglial syncytium plays a crucial role in such process by controlling the homeostasis of ions and water through the selective transmembrane movement of inorganic and organic molecules and the equilibration of osmotic gradients. Astrocytes, in fact, by contacting neurons and cells lining the fluid-filled compartments, are in a strategic position to fulfill this role. They are endowed with ion and water channel proteins that are localized in specific plasma membrane domains facing diverse liquid spaces. Recent data in rodents have demonstrated that the precise dynamics of the astroglia-mediated homeostatic regulation of the CNS is dependent on the interactions between water channels and ion channels, and their anchoring with proteins that allow the formation of macromolecular complexes in specific cellular domains. Interplay can occur with or without direct molecular interactions suggesting the existence of different regulatory mechanisms. The importance of molecular and functional interactions is pinpointed by the numerous observations that as consequence of pathological insults leading to the derangement of ion and volume homeostasis the cell surface expression and/or polarized localization of these proteins is perturbed. Here, we critically discuss the experimental evidence concerning: (1) molecular and functional interplay of aquaporin 4, the major aquaporin protein in astroglial cells, with potassium and gap-junctional channels that are involved in extracellular potassium buffering. (2) the interactions of aquaporin 4 with chloride and calcium channels regulating cell volume homeostasis. The relevance of the crosstalk between water channels and ion channels in the pathogenesis of astroglia-related acute and chronic diseases of the CNS is also briefly discussed

    Barocco italiano; Giovan Battista Basile

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    Si tratta di due capitoli del volume Letteratura curato da Giulio Ferroni, in cui si definiscono le coordinate del Barocco in una chiave originale e si rivede l'opera del Basile, considerando non soltanto il Cunto de li Cunti, ma anche le opere volgari.These are two chapters of the volume titled Letteratura, ed. by Giulio Ferroni; the first is dedicated to a reassessment of the concept of Baroque in a new perspective; the second is a little monograph about the author of Lo Cunto de li Cunti, considering also his literary production in italian language

    Notizie sulla corrispondenza di Antonietta Ferroni Tommasini

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    The essay intends to present the general characteristics, the main interlocutors and the recurring themes of the correspondence of the Parma scholar Antonietta Ferroni (1780-1839), author of pedagogical and biographical works, linked by ties of friendship to Leopardi and Giordani. Preserved in the Palatina Library of Parma, the letters allow us to reconstruct the personal relationships (above all, but not only, from Parma and Bologna, and extended to authors of pedagogical texts), readings, cultural interests and publishing activity of the addressee, wife of the doctor Giacomo Tommasini and with him for a long time in epistolary relationship

    Opere del Venerable D. Tomaso da Kempis, Canonigo Regolare

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    Sign.: a\p4\s, A-T\p12\s, V\p1\sPort. con grav. xilAntepA il. é un grav. calc. retrato do auto
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