497 research outputs found
Le Bundesrat. La protection des intérêts des Länder selon la Loi fondamentale allemande
No full textAfter dealing with the West German Bundersrat in a double-chamber system, the author, following the Basic Law of the country, depicts the varied powers of this Chamber. The participation of the Bundersrat in federal legislation is examined through its suspensive veto over every bill adopted by the first chamber — the Bundestag. The Bundersrat also has the power to approve certain categories of Bills. The participation of the Bundersrat in the federal administration, contentious powers and the nomination process are ideas also developed in this article. The author examines the political role of the Chamber and shows that the Bundersrat has a counterbalancing effect between the Bundestag and the federal government. The importance of the roles of the parties in developing the political position of the Bundersrat is also discursed herein. Professor Bothe concludes by saying that the Bundersrat is an important element of West German cooperative federalism and wonders if exporting this institution to Canada would be a wise move
Design of an analytical solution for the reduction of supply chain losses in the context of international logistics
No full textTato práce se zabývá praktickým řešením businesového problému v oblasti nízké kontroly a visibility nákladů v rámci dodavatelsko – odběratelského řetězce v kontextu mezinárodní kontejnerové logistiky a implementací self-service business intelligence, aplikací BI nástroje Microsoft Power BI, Power Query jako plnohodnotný ETL nástroj a využití Microsoft O365 nástrojů. Praktickou projektovou metodologií pro implementaci celkového řešení a základními přístupy řešení data governance modelu. Principy návrhu jednotlivých dashboardů a efektivní řešení architektury s důrazem na maximální vzužití stávající infrastruktury a zdrojů. Hlavním cílem je návrh a implementace reportingového a analztického prostředí, které zefektivní process kontroly a reportování logistických nákladů a umožní efektivní využití času jednotlivých uživatelů k analýze a stanovování efektivních kontrolních mechanismů, které povedou k prevenci vzniku nákladů. Nezbytnými dílčími cíli práce je dokumentace datových zdrojů a procesů v dané oblasti, návrh governance procesu a identifikace potenciálních oblastí k větší efektivitě. Výsledkem práce je ověření spokojenosti s dodaným řešením jednotlivými klíčovými uživateli.This paper is focusing on delivering practical solution for solution of business problem with low visibility and cost control in supply chain in context of international container logistics, it provides end-to-end implementation self-service BI environment using Microsoft Power BI tool, Microsoft Power Query and Microsoft O365 tools. It provides practical project methodology for overall project delivery, general approach for implementation of data governance model, approaches to design reports and dashboards and effective set up od data architecture with focus on maximum usage of existing tools and resources. Main goal is to implement reporting and analytic solution that will enable data driven decision making and increase productivity of the users that will enable more focus on root cause analysis and implementation of preventive measures. Partial goals of the project are also to document data sources and processes in the area, set up of governance model proposal and identification of further process improvements. Outcome of the project is evaluated by satisfaction of key business stakeholders with delivered solution
Súčasné prístupy k nákladovej alokácii a vývoj typizovaného programového rozhrania v nástroji IBM Cognos TM1
No full textDiplomová práca sa orientuje na súčasné trendy prístupu k nákladovej alokácii v nástroji IBM Cognos TM1. Koncept, ktorý bol po prvýkrát rozpracovaný v mojej bakalárskej práci, začal v poslednom čase narážať na obmedzenia, spôsobené zvyšujúcimi sa nárokmi na analytické nástroje a informácie, ktoré poskytujú. Cieľom práce je preto analyzovať príčiny vznikajúcich slabín, navrhnúť a implementovať optimalizované riešenie spĺňajúce súčasné požiadavky. Vzhľadom na kvantitatívne zhodnotenie dosiahnutých výsledkov je práca rozšírená o analýzu rámcov a štandardov určených na porovnávanie OLAP nástrojov a ich syntézu do vlastného komplexného modelu. Model sa špecializuje na meranie viacerých OLAP aplikácií cez 4 základné perspektívy obsahujúce výkon, vývoj, použiteľnosť a finančné benefity. Dosiahnuté výsledky potvrdzujú, že inovovaný model je rýchlejší, bohatší na informácie, jednoduchší na použitie a vhodný pre organizácie so štrukturovaným a algoritmickým prístupom k nákladovej alokácií. Druhá časť práce sa zameriava na rozšírenie prezentačnej vrstvy aplikácie do webového rozhrania a vývoj typizovaných vizualizácií pre najrozšírenejšie analytické úlohy. Vzhľadom na absenciu pokročilého aplikačného rozhrania nástroja IBM Cognos TM1 je práca rozšírená o teoretickú analýzu súčasných trendov pri vývoji API a následným návrhom konceptu, umožňujúcim komunikáciu a predávanie dát medzi aplikáciou a TM1 serverov. V záverečnej časti práce je koncept zhmotnený do univerzálnej knižnice vyvinutej v jazyku PHP a aplikovaný na aktualizovaný model alokátora. Využitím knižnice sú následne vyvinuté dve vzorové koncepty rozhraní pre ovládanie a prácu s modelom. Získané poznatky môžu slúžiť ako podklad pre vývoj ďalších komponentov komunikujúcich s TM1 v najrozšírenejšej palete projektov alebo ako teoretický základ pri tvorbe API vo všeobecnosti.Thesis is devoted to current trends in approaching cost allocation developed in IBM Cognos TM1 software. Concept, which was originally elaborated in my bachelor thesis, has recently experienced restrictions caused by increasing requirements on analytical tools and information they provide. Goal of the thesis is therefore to analyse causalities of emerging weaknesses, design and develop optimalized and reengineered solution answering current demands. Reqarding the quantitative evaluation of attained results, the thesis is extended with analysis of frameworks and standards dedicated to benchmarking of OLAP tools and their synthesis into own complex model. Proposed model specializes on measuring multiple OLAP applications across four main perspectives including performance, development, usability and financial benefits. Attained results prove, that reengineered model is faster, data richer, easier to use and appropriate for any organization with structured and algorithmic approach to cost allocation. Second half of the thesis focuses on extending the presentation layer to web browser, designing and developing of custom visualizations for most usual analytic tasks. Considering the absence of advanced application interface in IBM Cognos TM1, the thesis also includes theoretical analysis of current trends in API development and design of concept allowing communication and data transportation between applications and TM1 server. In the concluding section of the thesis, proposed concept is materialized into universal library developed in PHP and applied to novel allocation model. Leveraging the library, two exemplary interfaces for allocator operation and data consumption are implemented. Gained knowledge can serve as basis for development of additional components communicationg with TM1 in variety of projects or theoretical framework for API implementation in general
Súčasné prístupy k nákladovej alokácii a vývoj typizovaného programového rozhrania v nástroji IBM Cognos TM1
No full textThesis is devoted to current trends in approaching cost allocation developed in IBM Cognos TM1 software. Concept, which was originally elaborated in my bachelor thesis, has recently experienced restrictions caused by increasing requirements on analytical tools and information they provide. Goal of the thesis is therefore to analyse causalities of emerging weaknesses, design and develop optimalized and reengineered solution answering current demands. Reqarding the quantitative evaluation of attained results, the thesis is extended with analysis of frameworks and standards dedicated to benchmarking of OLAP tools and their synthesis into own complex model. Proposed model specializes on measuring multiple OLAP applications across four main perspectives including performance, development, usability and financial benefits. Attained results prove, that reengineered model is faster, data richer, easier to use and appropriate for any organization with structured and algorithmic approach to cost allocation. Second half of the thesis focuses on extending the presentation layer to web browser, designing and developing of custom visualizations for most usual analytic tasks. Considering the absence of advanced application interface in IBM Cognos TM1, the thesis also includes theoretical analysis of current trends in API development and design of concept allowing communication and data transportation between applications and TM1 server. In the concluding section of the thesis, proposed concept is materialized into universal library developed in PHP and applied to novel allocation model. Leveraging the library, two exemplary interfaces for allocator operation and data consumption are implemented. Gained knowledge can serve as basis for development of additional components communicationg with TM1 in variety of projects or theoretical framework for API implementation in general
Optimalizácia nákladov a profitability produktov využitím what-if analýzy v recipročnej alokačnej aplikácii
No full textThesis is focused on one of the most discussed area of Management Information Systems currently -- Corporate Performance Management. It does not aim on detail explanation of theme itself, but orientate to specific problematic of setting key solution of managerial accounting -- cost allocation, to the Performance Management systems. Thesis is divided into theoretical and practical part. First part is devoted to Corporate Performance Management definition, its placement in architecture of Business Intelligence devices as well as reasoning for its implementation considering current economical situation. From the main three pillars of Performance Management is major attention dedicated to analytical part enabling execution of what-if analyses. Part devoted to cost allocation identifies contributions of its implementation in optimization and minimization of expenditures as well as offers reasons for using them in bank sphere. Practical case study documents particular project phases of implementation of cost allocation analytical solution in fictive bank, while major section is dedicated to architecture and design part of the calculation engine. Project is concluded with description and explanation of advanced implementation techniques and methods in IBM Cognos TM1 software
Processo di analisi di campioni di voce di un individuo per verificare il suo stato di salute
No full textProcesso di analisi della voce di un individuo per indagare sul suo stato di salute, in particolare da usare come ausilio per la diagnosi di malattie. L’invenzione permette senza alcun intervento invasivo sul paziente di determinare variazioni del suo stato di salute mediante l’analisi del suono emesso dalla sua bocc
The molecular setup of the avian head mesoderm and its implication for craniofacial myogenesis
No full textThe head mesoderm is the mesodermal tissue on either side of the brain, from forebrain to hindbrain levels, and gives rise to the genuine head muscles. Its relatedness to the more posterior paraxial mesoderm, the somites, which generate the muscles of the trunk, is conversely debated. To gain insight into the molecular setup of the head mesoderm, its similarity or dissimilarity to the somitic mesoderm, and the implications of its setup for the progress of muscle formation, we investigated the expression of markers (1) for mesoderm segmentation and boundary formation, (2) for regional specification and somitogenesis and (3) for the positive and negative control of myogenic differentiation. We show that the head mesoderm is molecularly distinct from somites. It is not segmented; even the boundary to the first somite is ill-defined. Importantly, the head mesoderm lacks the transcription factors driving muscle differentiation while genes suppressing differentiation and promoting cell proliferation are expressed. These factors show anteroposteriorly and dorsoventrally regionalised but overlapping expression. Notably, expression extends into the areas that actively contribute to the heart, overlapping with the expression of cardiac markers
European Union Law: fundamental concepts
No full textForward
The present work of Professor Anja Bothe is a very important aid to the study of European Union Law. Aimed at the general public, it serves differently several sectors or sub-publics. Those who are now beginning their study of this discipline will easily understand its internal organization and know how to articulate the various substantive, institutional, and procedural issues. They will be able to apprehend the juseuropean tree of knowledge, visualizing its trunk and its branches. This will facilitate the deepening of their studies and allow them to move further to more demanding levels. For those who never studied European Union Law systematically but, namely because of professional reasons, have access to many sources of information about the European Union, this book provides a quick and effective way of structuring the information they collect, knowing where and how they should arrange it conceptually and schematically. In this way, they will avoid forgetting, misunderstanding or ignoring basic and structural questions. For those who are already very familiar with European Union law, this work allows a recapitulation of the subject, allowing through the visualization of the most important aspects recall those secondary aspects that directly relate to them. For these and other reasons, this work can therefore be very useful in academic and professional contexts where it is useful or necessary to move from point A to point B by quickly convening knowledge of the central aspects of European Union Law.
Jónatas E. M. Machado
Professor of Law of the European Union
Faculty of Law of the University of Coimbra and Autonomous University of Lisbon (UAL)A basic understanding of the structure and operation of the European Union is essential, not only for all branches of law, but also for management, public relations, marketing, communication, sociology and the economy. Moreover, citizens may find this book very relevant and useful in capturing the fundamental notions underlying the EU, which may cause great impacts on everybody´s daily life. The author, Anja Bothe, concluded her Ph.D. at the Law Faculty of Hamburg. She teaches several branches of law, some of them in English, at the School of Management Sciences, Health, IT & Engineering Atlântica of Barcarena, and at the University Autonoma of Lisbon, where she is also integrated in the Investigation Center of the Law Department called Ratio Legis
Carboranyl bisglycosides for the treatment of cancer by boron neutron capture therapy
No full textBoron neutron capture therapy is a special type of radiotherapy for the treatment of cancer by using boron compounds. Problems often arise from the: low water solubility of these compounds, their unselective uptake into the cancer cells, and their toxicity Here we describe the novel water-soluble ortho-carboranyl bisglycosides 7 and 10 containing either lactose or glucose and the mixed bisglycosides 1 and 28 containing glucose mannose, and galactose. The carboranyl bisglycosides show almost no toxicity toward bronchial carcinoma cells of line A549 up to a concentration of 0.50 mM As anticipated, these compounds exhibit nearly no uptake into C6 glioma cells; they can therefore be used for a selective delivery into malignant cells:by using conjugates of glycohydrolases and monoclonal antibodies which bind to tumor-associated antigens, since by enzymatic hydrolysis the bisglycosides are transformed into lipophilic compounds
Modelování, analýza a počítačové simulace heterogenní katalýzy v mikroreaktorech
No full textTato prace se zabývá nelineárním systémem parciálních diferenciální rovnic, konkrétně kombinací tzv. reakce-difuze, resp. konvekce difuze. Tato situace odpovidá popisu heterogenní catalýzy, kdy zkoumame je proudění objemových částic buzené sta- cionarním rychlostním polem. Absorptční mechanismy na stenach jsou popsané pomocí Langmir-Hinschelwoodovy absoprční kinetiky a jednosměrné povrchové reakce odpoví- dají zákonu zachování objemu všech částic. Tyto fyzikální jevy se přirozeně vyskytují u mnoha aplikací heterogenní katalýzy. V první části práce se zaměřujeme na analýzu sys- tému. Dokážeme existenci a jednoznačnost tzv. "mild" řěšení využitím teorie nelineárních semigrup. Ve druhé části práce presentujeme numerické metody, které jsme použili pro výpočet numerického řešení, a které splňují všechna analytická a fyzikalní kritéria, tudíž jsou vhodným nastrojem k výpočtu modelu popisujících heterogenní katalýzu v reálném prumyslovém využití. Klíčová slova: heterogenní katalýza, sparovaný reakce-difuze a konvekce-difuze system, teorie nelineárních semigrup, bio-diesel mikroreaktor 1We investigate a nonlinear reaction-diffusion system coupled with convection- diffusion system. This combined system corresponds to physical description of heteroge- neous catalysis when the flow of bulk-constituents is driven by a given stationary velocity field; diverse mechanisms between bulk- and surface-parts of the model-domain are de- scribed by Langmuir-Hinshelwood absorption kinetics; and the irreversible reactions on the catalytic walls meets the law of mass action with quadratic rate. The first part of the thesis is focused on analytical results; in Chapter 2 we prove existence and unique- ness of a mild solution for so-called near-by problem using nonlinear semigroup theory; in Chapter 3 we investigate the weak formulation of the problem. We prove an existence of a weak solution for little modified problem which, under an assumption, coincides with the original problem. In the second part of the thesis (Chapter 4) we numerically investigate the evolution of the bio-diesel microreactor. We compute numerical solutions using several methods and we test the results by analytical and physical conditions; with the aim to find the most efficient way to compute precise and physically correct solution. Keywords: heterogeneous catalysis, coupled reaction-diffusion/convection-diffusion system, nonlinear...Matematický ústav UKMathematical Institute of Charles UniversityMatematicko-fyzikální fakultaFaculty of Mathematics and Physic
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