45 research outputs found
Construction Of Measurement Instruments In The Area Of Health [construção De Instrumentos De Medida Na área Da Saúde]
No full textMeasurement instruments are an integral part of clinical practice, health evaluation and research. These instruments are only useful and able to present scientifically robust results when they are developed properly and have appropriate psychometric properties. Despite the significant increase of rating scales, the literature suggests that many of them have not been adequately developed and validated. The scope of this study was to conduct a narrative review on the process of developing new measurement instruments and to present some tools which can be used in some stages of the development process. The steps described were: I-The establishment of a conceptual framework, and the definition of the objectives of the instrument and the population involved; II-Development of the items and of the response scales; III-Selection and organization of the items and structuring of the instrument; IV-Content validity, V-Pre-test. This study also included a brief discussion on the evaluation of the psychometric properties due to their importance for the instruments to be accepted and acknowledged in both scientific and clinical environments.203925936Cano, S.J., Hobart, J.C., The problem with health measurement (2011) Patient Prefer Adherence, 5, pp. 279-290Marx, R.G., Bombardier, C., Hogg-Johnson, S., Wright, J.G., Clinimetric and psychometric strategies for development of a health measurement scale (1999) J Clin Epidemiol, 5 (2), pp. 105-111Keszei, A., Novak, M., Streiner, D.L., Introduction to health measurement scales (2010) J Psychosom Res, 68 (4), pp. 319-323Rattray, J., Jones, M.C., Essential elements of questionnaire design and development (2007) J Clin Nurs, 16 (2), pp. 234-243Gallasch, C.H., Alexandre, N.M.C., Amick, B., III, Cross-cultural adaptation, Reliability, and validity of the Work Role Functioning Questionnaire to Brazilian Portuguese (2007) J Occup Rehabil, 17 (4), pp. 701-711Vigatto, R., Alexandre, N.M.C., Correa Filho, H.R., Development of a Brazilian Portuguese version of the Oswestry Disability Index. Cross-cultural adaptation, reliability, and validity (2007) Spine, 32 (4), pp. 481-486Nakajima, K.M., Rodrigues, R.C.M., Gallani, M.C.B.J., Alexandre, N.M.C., Oldridge, N., Psychometric properties of MacNew Heart Disease Health-related Quality of Life Questionnaire: Brazilian version (2009) J Adv Nurs, 65 (5), pp. 1084-1094Toledo, R., Alexandre, N.M.C., Rodrigues, R.C.M., Psychometric evaluation of a Brazilian Portuguese version of the Spitzer Quality of Life Index in patients with low back pain (2008) Rev Lat Am Enfermagem, 16 (6), pp. 943-950Cano, S.J., Hobart, J.C., Fitzpatrick, R., Bhatia, K., Thompson, A.J., Warner, T.T., Patient-based outcomes of cervical dystonia: A review of rating scales (2004) Mov Disord, 19 (9), pp. 1054-1059Chen, C.M., Cano, S.J., Klassen, A.F., King, T., McCarthy, C., Cordeiro, P.G., Morrow, M., Pusic, A.L., Measuring quality of life in oncologic breast surgery: A systematic review of patient-reported outcome measures (2010) Breast J, 16 (6), pp. 58-97Streiner, D.L., Norman, G.R., (2008) Health measurement scales. 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(2007) Value Health, 10, pp. S94-S10
Initial stages of graphene oxide cracking in basic media
No full textDespite the increasing interest in graphene oxide (GO) and its properties, currently there is no consensus on its structure. In the recently proposed two-component model, the GO structure consists of slightly oxidized graphene sheets and small organic molecules physisorbed on them. The formation of these molecules has been later attributed to the GO rupture caused by basic treatment under heating. In this work, we studied the initial stages of the GO rupture in hydroxyl chains by using first principles electronic calculations. Possible routes to cracking originated from different configurations of hydroxyl chains and under possible reactions in basic media were analyzed. Resulting from successive hydroxide ion attacks, cracks were observed for chains with hydroxyls arranged in armchair and zigzag configurations. Bond breaking due to the presence of ketones located at opposite sides of the basal plane was shown to play a role on cracking initiation and propagation. Cracking driven by structural deformations was also observed for chains comprised of parallelly orientated vicinal diols142217223FAPESB – Fundação de Amparo á Pesquisa Do Estado Da Bahia2010/50646-6; 2016/01736-
Compressive response and deformation mechanisms of vertically aligned helical carbon nanotube forests
No full text
Rotational Dynamics And Polymerization Of C60 In C60 -cubane Crystals: A Molecular Dynamics Study
No full textWe report classical and tight-binding molecular dynamics simulations of the C60 fullerene and cubane molecular crystal in order to investigate the intermolecular dynamics and polymerization processes. Our results show that, for 200 and 400 K, cubane molecules remain basically fixed, presenting only thermal vibrations, while C60 fullerenes show rotational motions. Fullerenes perform "free" rotational motions at short times (1 ps), small amplitude hindered rotational motions (librations) at intermediate times, and rotational diffusive dynamics at long times (10 ps). The mechanisms underlying these dynamics are presented. Random copolymerizations among cubanes and fullerenes were observed when temperature is increased, leading to the formation of a disordered structure. Changes in the radial distribution function and electronic density of states indicate the coexistence of amorphous and crystalline phases. 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Identifying Relevant Molecular Descriptors Related To Carcinogenic Activity Of Polycyclic Aromatic Hydrocarbons (pahs) Using Pattern Recognition Methods.
No full textPolycyclic Aromatic Hydrocarbons (PAHs) constitute an important family of molecules capable of inducing chemical carcinogenesis. In this work we report structure-activity relationship (SAR) studies for 81 PAHs using the pattern-recognition methods Principal Component Analysis (PCA), Hierarchical Clustering Analysis (HCA) and Neural Networks (NN). The used molecular descriptors were obtained from the semiempirical Parametric Method 3 (PM3) calculations. We have developed a new procedure that is capable of identifying the PAHs' carcinogenic activity with an accuracy higher than 80%. PCA selected molecular descriptors that can be directly correlated with some models proposed to PAHs' metabolic activation mechanism leading to the formation of PAHs-DNA adducts. PCA, HCA and NN validate the energy separation between the highest occupied molecular orbital and its next lower level as a major descriptor defining the carcinogenic activity. This descriptor has been only recently discussed in the literature as one new possible universal parameter for defining the biological activity of several classes of compounds.421479-8
