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Psoriazisli hastalarda kontakt duyarlılık
No full textBu tezin, veri tabanı üzerinden yayınlanma izni bulunmamaktadır. Yayınlanma izni olmayan tezlerin basılı kopyalarına Üniversite kütüphaneniz aracılığıyla (TÜBESS üzerinden) erişebilirsiniz.8. CONTACT SENSITIZATION IN PATIENTS WITH PSORIASIS Psoriasis is a skin disease characterized by sharply demarcated erythematous papules and plaques, which are covered by silvery scales. Although the pathogenesis remains elusive, it is claimed that triggering factors and immunological events especially T cell mediated delade type hypersensitivity play a role in the disease. Allergic contact dermatitis, one of the dermatoses caused by T cell mediated delayed type hypersensitivity, which presents clinically as eczema develops when the patients become sensitized against one or more chemicals. Patch testing can give definitive information about the cause of allergic contact dermatitis. Thus, T cells play a role in the pathogenesis of both disease. Since psoriasis can be triggered by physical and chemical trauma via Koebner phenomenon and some psoriatic patients especially with palmoplantar involvement can be resistant to therapy, it has been suggested that contact sensitization are common in psoriatic patients. Based on these data, 65 psoriatic patients (37 female, 28 male) and 57 control patients (33 female, 24 male) were investigated with patch tests in order to find out the incidence of contact sensitization applying European standart series. Ki-squere test, Student-t test and Fischer exact test were used for statistical analyses of the data. While 32,3 % of the psoriatic patients had positive patch tests to at least one allergen, only 12,3 % of the control group was determined to have positive patch tests, (p 0,01). Also there was a statistically significant difference between the psoriasis and control groups with respect to sensitivity to more than one allergen (p 0,05). The frequency of contact sensitivity did not show any significant difference between the clinical forms of psoriasis (p > 0,05). While the most frequent allergen was nickel in psoriatic patients, neomycin was the most frequent allergen in the control group. 60In our study, the frequency of contact sensitization determined in psoriatic patients was higher than in control subjects. This finding suggested the possible role of contact allergens in the pathogenesis of psoriasis. Although the proportion of our psoriatic patients with or without positive patch test reactions between the clinical types was found to be similar, it would be appropriate to evaluate the probable contact sensitization via patch testing especially in psoriatic patients with palmoplanar involvement according to the literature. In addition it was reported that the drugs used for topical treatment of psoriasis could cause resistance to treatment via contact sensitization. For this reason, patch testing with extended series including topical medicaments and avoidence of determined allergens may lead to an improvement in some recalcitrant forms of psoriasis. 617. Psoriazis; keskin sınırlı, eritemli, gümüş rengi skuamlı papül ve plaklarla karakterize bir deri hastalığıdır. Etyopatogenezi kesin olarak bilinmemekle birlikte genetik bir zeminde tetikleyici ajanların etkisiyle ortaya çıkan ve özellikle T hücre aracılı geç tip aşın duyarlılık olmak üzere immünolojik olayların rolü olduğu ileri sürülen bir dermatozdur. T hücre aracılı geç tip aşırı duyarlılığın klinikte gözlenen örneklerinden biri olan allerjik kontakt dermatit ise organizmanın daha önceden duyarlanmış olduğu allerjen özellikteki bir madde ile tekrar karşılaşmasıyla gelişen bir ekzema olup tanısında yama testi yardımcı bir tanı yöntemi olarak kullanılmaktadır. Her iki hastalığın etyopatogenezinde T hücrelerin rol oynaması, psoriaziste sağlam deriye uygulanan fiziksel veya kimyasal travmaların Koebner fenomeni etkisiyle lezyonları başlatabilmesi ve özellikle palmoplantar tutulumu olan bazı psoriazis hastalarının tedaviye dirençli olması gibi nedenlerle psoriazis hastalarında artmış kontakt duyarlılık olabileceğinden söz edilmektedir. Bu verilere dayanarak 37 kadın 28 erkek hastadan oluşan 65 psoriazis olgusunda ve kontakt dermatiti olmayan 33 kadın 24 erkek hastadan oluşan toplam 57 kontrol olgusunda "Avrupa standart serisi" kullanılarak kontakt duyarlılık oranlan karşılaştırıldı. Verilerin istatistik değerlendirmesi için Ki- kare, Student- 1 test ve Fisher exact testleri kullanıldı. Psoriazisli olgularda en az bir allerjene karşı pozitiflik oranı % 32,3 bulunurken kontrol olgularında %12,3 saptandı (p 0,01). Yine birden fazla allerjene duyarlılık açısından da psoriazis ve kontrol olguları arasındaki fark anlamlı bulundu (p 0,05). Psoriazisli olgularda klinik tipler arasında kontakt duyarlılık açısından anlamlı fark saptanmadı (p > 0,05). Psoriazis olgularında en fazla pozitiflik saptanan allerjen nikel olurken kontrol grubunda en sık neomisin saptandı. Çalışmamızda psoriazisli hastalarda kontakt duyarlılık sıklığının kontrollerden daha yüksek saptanması, psoriazis patogenezinde kontakt 58allerjenlerin de tetikleyici olarak rol oynayabileceğini düşündürmektedir. Psoriazis klinik tipleri arasında ise kontakt duyarlılık açısından fark saptanamamasına karşın, literatür bilgileri ışığında özellikle palmoplantar psoriazis olgularında yama testi yapılarak olası bir kontakt duyarlılığın araştırılması önerilmektedir. Yine literatürde, kullanılan topikal ilaçların kontakt duyarlanma oluşturarak sağaltıma direnç gelişmesine neden olabileceği bildirilmektedir. Bu nedenle sağaltıma dirençli psoriazis olgularında topikal ilaçlan da içeren genişletilmiş serilerle yama testi yapılması ve saptanan allerjen maddelerden sakınılması hastalığın sağaltımına yardımcı olabilecektir. 5
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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