1,209 research outputs found
Tettagalma Menon, new genus
No full text<i>Tettagalma</i> Menon, new genus <p> <b>Diagnosis.</b> Medium­sized (25 mm forewing length) tettigarctid; prominent costal margin; Rs with three branches; origin of MA branches proximal to nodal line; CuA strongly deflected anteriorly at nodal line; wide marginal membrane; marginal membrane bearing numerous, equidistant striae.</p> <p> <b>Etymology.</b> Genus­group name formed from a combination of <i>tetti</i> in reference to the family and <i>agalma</i> from the Greek present, gift, as the specimen was donated to the author.</p> <p> <b>Type locality and horizon.</b> Vicinity of Nova Olinda, Nova Olinda Member, Crato Formation.</p> <p> <b>Type species.</b> <i>Tettagalma striata</i> Menon new genus and species, by monotypy.</p>Published as part of <i>Menon, Federica, 2005, New record of Tettigarctidae (Insecta, Hemiptera, Cicadoidea) from the Lower Cretaceous of Brazil, pp. 53-58 in Zootaxa 1087</i> on page 54, DOI: <a href="http://zenodo.org/record/170508">10.5281/zenodo.170508</a>
Abstract KP01: UNITED KINGDOM COLLABORATIVE TRIAL OF OVARIAN CANCER SCREENING – (UKCTOCS) – EXPLORING THE RESULTS
No full textAbstract
The continued high case fatality ratio in ovarian cancer has underpinned efforts to develop a screening strategy that could impact on mortality. In the general population randomised control trial - United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) two screening strategies (multimodal MMS and ultrasound USS) were compared to no screening (control C). Of 202,638 women randomised between April 2001-October 2005, 50,624 MMS; 50,623 USS; and 101,299 C were eligible for analysis. By the end of screening (December 2011) 345,570 MMS and 327,775 USS annual screens were performed. At censorship for the initial mortality analysis on 31st December 2014, there was an overall significant stage shift in invasive epithelial ovarian/tubal/peritoneal cancer in the MMS group compared to C in an ‘intention to screen’ analysis. More detailed analysis has shown this stage shift seen in the MMS group was limited to Type II (high grade serous) ovarian cancers. This was associated with a delayed but not yet statistically significant mortality reduction. Disease specific mortality rates in the C arm were continuing to rise while they appeared to have plateaued in the screen arms. Further follow-up is now underway to confirm the mortality reduction and determine its full extent. Meanwhile a focus on detecting low volume disease using cancer specific markers, novel biospecimens such as endocervical samples, targeted imaging and time series algorithms for interpreting marker profile suggest that a new era in ovarian cancer screening is underway.
Citation Format: Usha Menon. UNITED KINGDOM COLLABORATIVE TRIAL OF OVARIAN CANCER SCREENING – (UKCTOCS) – EXPLORING THE RESULTS [abstract]. In: Proceedings of the 11th Biennial Ovarian Cancer Research Symposium; Sep 12-13, 2016; Seattle, WA. Philadelphia (PA): AACR; Clin Cancer Res 2017;23(11 Suppl):Abstract nr KP01.</jats:p
Ovarian cancer screening in the general population.
No full textDespite significant improvements in therapy, ovarian cancer continues to be a leading cause of death amongst women with gynaecological malignancies. Advanced stage at diagnosis is thought to be a major contributor to mortality. Hence, there is considerable interest in early detection through screening. In the 1990s, Professor Jacobs pioneered the development of a multimodal ovarian cancer screening (OCS) strategy using serum CA125 as the first line screen and pelvic ultrasound as the second line test. This thesis summarises the next steps in the journey with refining of the screening algorithm, feasibility testing in a pilot randomised control trial (RCT) and finally setting up and recruiting 200,000 women into the largest ever RCT . The risk of ovarian cancer in postmenopausal women with elevated CA125 levels was established through a detailed analysis of 1219 pelvic scans from 741 women with raised CA125 levels in the completed trial of 22,000 women. Based on this, the multimodal 'Risk of Ovarian Cancer' (ROC) algorithm was refined and morphology instead of volume was used to interpret the ovarian scans. The refined ROC algorithm was then prospectively evaluated in a pilot RCT of 13,582 postmenopausal women. The trial established that screening using the ROC algorithm was feasible and could achieve high specificity and positive predictive value. The improved performance characteristics of the screening strategy and the experience accumulated in running and organising the pilot trial led to the design and successful implementation of a RCT - the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) - to assess the impact of early detection on disease mortality. The trial commenced in 2001 with recruitment of 202,638 postmenopausal women by September 2005. The issues involved in setting up the trial, recruitment of 202,000 women and the baseline characteristics of this population are described
6-year outcomes of the United Kingdom Medisoft® audit study following treatment with the ILUVIEN® (fluocinolone acetonide) implant in patients with diabetic macular edema.
No full textPurpose: The Medisoft study was designed as a retrospective audit of eyes treated with the fluocinolone acetonide (FAc) implant and aimed to assess the long-term effectiveness and safety of FAc implant in patients with diabetic macular edema (DME) that persists or recurs despite treatment. Outcomes from this study have previously been reported in patients monitored for ≥3 years. We now report outcomes obtained in the last 3-years since the initial outcomes were reported. Methods. The Medisoft audit tool was used to extract pseudo-anonymised electronic medical records (EMR), identifying only patients with DME that had been treated with the FAc implant across 14 UK clinical sites between 2014 and 2022. Clinical effectiveness and safety were measured.Results. Data were available from 302 eyes (256 patients) with ≥3 years of follow-up. The mean follow-up period was 64.2±18.4 months [mean±SD]). Best-recorded visual acuity (BRVA) was 56.8±15.6 letters, 59.2±17.1 letters and 60.54±15.6 letters at baseline, 3 and 6 years respectively. At years 3 and 6, stable/improved BRVA was observed in 75.6% and 74.6% respectively. The proportion of eyes with 6/12 (20/40) or better BRVA rose from 22.5% at baseline to 35.2% and 39.7%, respectively. In terms of safety, mean IOP was 16.3±4.1 mmHg at baseline and remained below a mean value of 21 mmHg at years 3 and 6. Around one third (36.1%) of eyes required topical IOP-lowering drops to control elevations in pressure (versus 21.5% of eyes pre-FAc implant) and IOP was >30 mmHg at a single time point post-FAc implant in 25.5% of eyes (versus 10.6 pre-FAc implant).Conclusions. Over a 6-year follow-up period, UK EMR data obtained in real-world practice revealed that three-out-of-four patients with DME and treated with a FAc implant benefited from stable/improved BRVA and that one-in-three had visual acuity 6/12 or better. This data was obtained since the first eye was treated in the UK and is an ongoing study that will continue to monitor the outcomes and the management of DME patients in clinical practice.<br/
Novel Dialogue 2.3: Because I Couldn't Be a Dancer: Sigrid Nunez and Tara Menon (JP)
No full textThe brilliant New York writer Sigrid Nunez's most recent novel is What Are You Going Through; her previous one, The Friend, (2018) won the National Book Award. She speaks with Tara Menon, of the Harvard English department, and author of a terrific article about Sigrid Nunez in the Sewanee Review. The conversation ranges widely and then plunges into depths. Because life is defined by grief and mourning, so too are my novels, says Nunez. She thinks her upbringing with immigrant parents who felt adrift from their homeland and her own "failure" as a dancer (recounted in her 1995 debut novel, A Feather on the Breath of God ) are the ferment from which her vocation as a writer arose. The question of genre is tossed around: "fictional memoir" perhaps, which gets confused (insultingly, Tara thinks!) with auto-fiction. But Sigrid is fascinated by establishing a reality that is entirely made-up ("not a single friend angry!"), yet also documentary in nature. Perhaps the best tag for her work is "essay novel": that allows one to do what Javier Marias calls "literary thinking." And there's a wonderfully non-Pavlovian answer to the treat question: sometimes you can just have the whiskey
A secondary analysis of acculturation, anxiety and depression among South Asian immigrants
No full textSouth Asian Americans (SAA) Americans (from Bangladesh, Bhutan, India, the Maldives, Nepal, Pakistan, and Sri Lanka) were one of the fastest growing ethnic group in the United States in the last two decades. However, this group has been understudied in the field of mental health. Cultural expression of symptoms of mental illness in SAA may vary significantly from westernized culture, or symptoms may cluster in different ways in different ethnic groups. Acquiring more information about the health-seeking behavior of SAA may help to promote culturally appropriate health care and education, and improve health outcomes for this minority group. The purpose of this secondary analysis is to determine the relationships between acculturation, medical mistrust, family resources, demographics and anxiety and depression in SAA. The parent study employed a cross-sectional, descriptive design with 330 SAA interviewed in English, Hindi, or Gujarati. The mean age of the participants was 58.9 years, the majority were married, and from India. The mean age of the participants was 58.9 years, the majority were married, and from India. Depression was related to the acculturation subscale of language; medical mistrust; the money, basic needs, and time subscales of family resources; and quantity and quality of social support, and being Hindu. Higher mean anxiety was significantly related to age, medical mistrust, money, basic needs, and time, quantity and quality of social support. In the final regression analyses, depression was predicted by gender, medical mistrust and having a regular physician, while anxiety was predicted only by having a regular physician.No embargoAcademic Major: Nursin
Recommended from our members
Factors Associated with Burnout in Medical Students
No full textObjectives: The aim of this literature review was to conduct a critical appraisal of the factors associated with medical students' burnout (BO). Specifically, we described associations between burnout and 1) sociodemographics (age, race/ethnicity, year in medical school, biological sex, etc.), 2) stress, sleep, spirituality, and social support, and 3) protective factors (factors that reduce burnout or the progression of it). Methods: English-language, peer-reviewed articles (published between 1997 and 2016) that examined burnout in medical students were identified through PubMed and PsyInfo. Searches included various combinations of the following terms: "medical students," "burnout," "associated factors," "spirituality," "social support," "medical school," and "depression." Remaining articles were pulled from the reference lists of the searched articles. Thirty-five articles were selected and relevant information was extracted. Results: For sociodemographics, burnout was: not associated with age, and positively associated with non-minority status, higher year in medical school, and being female. Burnout was associated positively with stress and inversely with sleep, spirituality and social support. Protective factors included: coping mechanisms, spirituality, social support, and adequate sleep. Conclusions: There are multi-level and multi-factorial associations with burnout. It is important to identify protective factors for early intervention to reduce burnout in medical students and the associated negative effects
A systematic review on the effectiveness and proper technique of repositioning for the prevention of pressure ulcers among immobile patients
No full textEvery year, it is estimated that a total of 2.5 million pressure ulcers are treated in the United States. However, while repositioning, that is changing patient position to alter pressure on the skin, is common practice, it is still unclear if this is the best method for preventing pressure ulcers. The purpose of this study was to conduct a systematic literature review to determine the strength of the evidence on repositioning immobile patients to prevent pressure ulcers. Using keywords associated with articles on the topic, two databases were searched: PUBMED and CINAHL. Inclusion criteria for articles were studies on humans, English language, and outcome being effect of repositioning. Fourteen articles met the inclusion criteria of this study, and data were abstracted to a standardized form. Nine studies supported the use of repositioning in pressure ulcer prevention to varying degrees and the other five concluded that more research was necessary. The best time intervals and process for repositioning were inconclusive. Although this systematic review did not find conclusive evidence to support repositioning, there was also no harm reported from following the practice. The majority of the studies reviewed found that repositioning does help prevent pressure ulcers. Further research is needed on the time intervals for repositioning, as well as the process such as using technology-driven mattresses versus simply moving patients to a different position.No embargoAcademic Major: Nursin
A priori and a posteriori analysis of the hybrid two-level large-eddy simulation method for high Reynolds number complex flows
No full textWe present a priori and a posteriori analysis of the assumptions and predictions of the hybrid two-level large-eddy simulation (TLS-LES) method for high Reynolds number complex flows. The TLS-LES methodology is a multi-scale framework for simulation of turbulent flows in complex configurations at practically relevant Reynolds number. It additively combines the two-level simulation (TLS) model with a conventional large-eddy simulation (LES) approach by employing a static or dynamic blending function. In the present study, first we analyze the model assumptions employed by the TLS model to obtain the small-scale solution necessary for closure of the large-scale equations. Afterward, we analyze the large-scale and small-scale solutions to assess the predictive ability of the multi-scale framework for specific turbulence physics such as role of forward and backscatter of energy and presence of co- and counter-gradient diffusion. To perform these investigations, we consider cases with increasing degree of geometrical complexity, namely, flow in a periodic channel, flow past a bump placed on the lower surface of the channel and flow past a finite-span NACA0015 airfoil
Il bene del filosofo e il limite della città. Sulla politica filosofica di Leo Strauss
No full textThe intention of this paper is to show how Leo Straussʼ mature writings respond to the twofold necessity of political philosophy: contributing, at the same time, to the good of the city and to the good of the philosophers. In the first place, it will try to prove this point by analyzing in detail the Introduction to On Tyranny (1948), which represents an essential step in order to understand the intention of the author. In the second place, it will tackle the problem of justice, that is, of natural right, by concentrating on the so called " tyrannical teaching ". This teaching is a way to present a truth which the city cannot find acceptable, that is, an unpleasant truth concerning the irresoluble problem of justice and legitimacy. In conclusion, it will point to the tension between philosophy, i.e., search for knowledge, and the city, i.e., the realm of opinion. For the philosopher, as such, has to " corrupt " the young in order to pursue his search for knowledge of the whole, or the nature of all things. Therefore, he weakens the city, since philosophizing implies unbelief in the gods of the city
- …
