2,828,970 research outputs found
Tagging of Biomedical Articles on CiteULike: A Comparison of User, Author and Professional Indexing
No full textThis paper examines the context of online indexing from the viewpoint of three different groups: users, authors, and professional indexers. User tags, author keywords and descriptors were collected from academic journal articles, which were both indexed in Pubmed and tagged on CiteULike, and analysed. Descriptive statistics, informetric measures, and thesaural term comparison shows that there are important differences in the use of keywords between the three groups in addition to similarities which can be used to enhance support for search and browse. While tags and author keywords were found that matched descriptors exactly, other terms which did not match but provided important expansion to the indexing lexicon were found. These additional terms could be used to enhance support for searching and browsing in article databases as well as to provide invaluable data for entry vocabulary and emergent terminology for regular updates to indexing systems. Additionally, the study suggests that tags support organisation by association to task, projects and subject while making important connections to traditional systems which classify into subject categories
Cathédrale Notre-Dame, Amiens, 1236
No full textPhotographie: Hartill Art Associates. AFr-0823; Date du début des travaux de réalisation : 1236
Cathédrale Notre-Dame, Amiens, 1236
No full textPhotographie: Hartill Art Associates. AFr-0825; Date du début des travaux de réalisation : 1236
miR-1236 regulates hypoxia-induced epithelial-mesenchymal transition and cell migration/invasion through repressing SENP1 and HDAC3
No full textIntratumoral hypoxia induces epithelial-mesenchymal transition and promotes cancer metastasis. MicroRNAs (miRNAs) are endogenous, single-strand RNA molecules that regulate gene expression. MiRNAs control cell growth, proliferation, differentiation and cell death and may function as oncogenes or tumor suppressors. HDAC3 and SENP1 are two molecules involved in hypoxia-induced EMT and HIF-1 alpha stability, respectively. In this report, we show that miR-1236 plays a critical role in hypoxia-induced EMT and metastasis. MiRNA prediction programs TargetScan and miRanda show that miR-1236 may target HDAC3 and SENP1. MiR-1236 represses the luciferase activity of reporter constructs containing 3'UTR of HDAC3 and SENP1 as well as the expression levels of HDAC3 and SENP1. MiR-1236 abolishes hypoxia-induced EMT and inhibits migration and invasion activity of tumor cells. Hypoxia represses miR-1236 expression. The promoter region of miR-1236 is identified as the NELFE promoter. Twist1, an EMT regulator activated by hypoxia/HIF-1 alpha, is shown to repress the reporter construct driven by the NELFE promoter. The binding site of Twist1 in the NELFE promoter is identified and chromatin immunoprecipitation assays show the direct binding of Twist1 to this site. Overexpression or knockdown of Twist1 in stable cell lines shows the inverse correlation between Twist1 and miR-1236 expression. These results identify a miRNA that regulates hypoxia-induced EMT and metastasis through repressing HDAC3 and SENP1 expression and present a regulatory network that involves many key players in hypoxia-induced EMT. (C) 2016 Elsevier Ireland Ltd. All rights reserved
Understanding the user - why, what and how?
No full textExplains the need, importance, purposes and scope of user studies, discusses procedure for conducting sound user studies together with associated problems of research like selection of problem, formulation of hypothesis, design of study, sampling strategy, data collection methods, scaling techniques, pilot study, processing and analysis of data, testing of hypothesis, interpretation, drawing inferences, communication and dissemination of results and finally concludes by highlighting methodological flaws and gaps in user studies
Quantifying the user experience : practical statistics for user research /
No full text"The primary purpose of this book is to provide a statistical resource for those who measure the behavior and attitudes of people as they interact with interfaces. The focus is on methods applicable to practical user research, based on our experience, investigations, and reviews of the latest statistical literature"--"The primary purpose of this book is to provide a statistical resource for those who measure the behavior and attitudes of people as they interact with interfaces. The focus is on methods applicable to practical user research, based on our experience, investigations, and reviews of the latest statistical literature"--Includes bibliographical references and index.Introduction and how to use this book -- Quantifying user research -- How precise are our estimates? confidence intervals -- Did we meet or exceed our goal? -- Is there a statistical difference between designs? -- What sample sizes do we need? part 1: summative studies -- What sample sizes do we need? part 2: formative studies -- Standardized usability questionnaires -- Six enduring controversies in measurement and statistics -- Wrapping up -- Appendix: a crash course in fundamental statistical concepts.Print version record.Elsevie
User, Author and Professional Indexing in Context: An Exploration of Tagging Practices on CiteULike
No full textThis paper examines the context of online indexing from the viewpoint of three different groups: users, authors, and intermediaries. User, author and intermediary keywords were collected from journal articles tagged on CiteULike and analysed. Descriptive statistics, informetric measures, and thesaural term comparison shows that there are important differences in the context of keywords from the three groups
miR-1236-3p suppresses the anti-bacterial viability of macrophages against mycobacterium tuberculosis by targeting toll-like receptor 4
No full textThis document is an additional material for " miR-1236-3p suppresses the anti-bacterial viability of macrophages against mycobacterium tuberculosis by targeting toll-like receptor 4 ".</p
Know your library : user orientation
No full textIn a recent longitudinal comparative study of card catalogue and OPAC of ISRO Satellite Centre (ISAC) Library, it was sadly noted that despite automation and meticulously developing, updating and maintaining nine databases on OPAC, almost doubling the number of registered members, collection and use of documents over the same period, use of OPAC has not much increased compared to use of card catalogue. It is often speculated that there is substantial decline in general reading habit and use of libraries over a generation. Promoting the use of OPAC (and multiple databases on them) through user education/ orientation instruction programmes was felt again and again. After all, OPAC, like card catalogue, continue to be one of the many means by which users discover bibliographic references of their potential interest. Having faced such a situation, gearing up user education/ orientation programmes particularly to new users and younger generation is much desired.
The purpose of user education is to make the end user searching as easy and as comfortable as possible, to minimise waiting time at the terminal and to avoid resorting to time consuming trial and error mode. Some of the new technologies are pretty easy to use but few can be effectively used without training. The need for training can be ascertained from the signs of novice users sitting in front of the terminal with lots of beeps, moving back and forth or from menu to menu and long periods of inactivity as well as the need expressed by users themselves.
In addition to extensive one-to-one assistance by professional staff and flip charts, new user induction and orientation programmes have been launched with visual animated presentation as well as lecture and discussion. Regular user orientation entitled "Know your library" consists of lecture cum demonstration on using various services followed by a local tour in small groups and distribution of informative brochure “Know your library” and “library user manual”. In the introduction, the presentation highlights the necessity of consumption skills among users, levels of user education and types of information covered in the presentation, a brief look at significant information-behaviour of engineers, display of selected parts of classification scheme followed by the library and finally the digital content and the non-book material collection of the library. Keeping aside common self-explanatory aspects of OPAC, Digital Library and the Internet, the presentation focused on features generally not known to users. Feedbacks from earlier studies on card catalogue and OPAC were also kept in mind. A series of A3-size colour charts with tips for effective use of OPAC, Internet, Digital Library, on-line and other information services were periodically designed and displayed at important places
Author Co-Citation Analysis (ACA): a powerful tool for representing implicit knowledge of scholar knowledge workers
No full textIn the last decade, knowledge has emerged as one of the most important and valuable organizational assets. Gradually this importance caused to emergence of new discipline entitled ―knowledge management‖. However one of the major challenges of knowledge management is conversion implicit or tacit knowledge to explicit knowledge. Thus Making knowledge visible so that it can be better accessed, discussed, valued or generally managed is a long-standing objective in knowledge management. Accordingly in this paper author co- citation analysis (ACA) will be proposed as an efficient technique of knowledge visualization in academia (Scholar knowledge workers)
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