96 research outputs found
Recommended from our members
Relational Care - with Mary Larkin and Manik Deepak-Gopinath [Podcast]
No full textWhat is 'relational care' and how can it improve the day-to-day experience of carers and those they care for? What are its implications for relationships between staff and service users in care settings? And how does the concept of relational care enable us to re-imagine the role of place and space in the experience of care? These are some of the questions we explore in this episode with Mary Larkin and Manik Deepak-Gopinath who recently completed a research project on the value and practice of relational care with older people.
Mary is Professor of Care, Carers and Caring at The Open University in the UK, where her research has focused on carers and caring and adult social care. She is the co-author, most recently of Family Carers and Caring, published in 2023 by Emerald. Manik is a Lecturer in Ageing, also at The Open University, and is a critical gerontologist with interests in the intersection of ageing, place and wellbeing, and in the intimate and family ties of older adults
Properties of LDGM-LDPC codes with applications to secrecy coding
No full textThe ensemble of low-density generator-matrix/low-density parity-check (LDGM-LDPC) codes has been proposed in literature. In this thesis, an irregular LDGM-LDPC code is studied as a sub-code of an LDPC code with some randomly emph{punctured} output-bits. It is shown that the LDGM-LDPC codes achieve rates arbitrarily close to the channel-capacity of the binary-input symmetric-output memoryless (BISOM) channel with a finite lower-bound on the emph{complexity}. The measure of complexity is the average-degree (per information-bit) of the check-nodes for the factor-graph of the code. A lower-bound on the average degree of the check-nodes of the irregular LDGM-LDPC codes is obtained. The bound does not depend on the decoder used at the receiver. The stability condition for decoding the irregular LDGM-LDPC codes over the binary-erasure channel (BEC) under iterative-decoding with message-passing is described. The LDGM-LDPC codes are capacity achieving with bounded complexity and possess natural binning/nesting structure. These codes are applied to secrecy coding. The problem of secrecy coding for the type-II binary symmetric memoryless wiretap channel is studied. In this model, the main channel is binary-input and noiseless and the eavesdropper channel is binary-symmetric memoryless. A coding strategy based on emph{secure nested codes} is proposed. A capacity achieving length- code for the eavesdropper channel bins the space into co-sets which are used for secret messaging. The resulting co-set scheme achieves secrecy capacity of the type-II binary symmetric memoryless channel. As an example, the ensemble of capacity-achieving regular low-density generator-matrix/low-density parity-check (LDGM-LDPC) codes is studied as a basis for binning. The previous result is generalized to the case of a noisy main-channel. The problem of secrecy-coding for a specific type-I wiretap channel is studied. In the type-I wiretap channel under consideration, the main channel is a binary-input symmetric-output memoryless (BISOM) channel and the eavesdropper channel is a binary-symmetric channel (BSC). A secure-nested-code that achieves perfect-secrecy for the above type-I channel is proposed. The secure-nested-code is based on a nested regular LDGM-LDPC code construction.M.S.Includes bibliographical referencesby Manik RainaIncludes abstrac
The Immunogenomic Landscape of Neuroendocrine Prostate Cancer
No full textPurpose: Patients with neuroendocrine prostate cancer (NEPC) are often managed with immunotherapy regimens extrapolated from small cell lung cancer (SCLC). We sought to evaluate the tumor immune landscape of NEPC compared to other prostate cancer types and SCLC. Experimental design: In this retrospective study, a cohort of 170 patients with 230 RNA sequencing and 104 matched whole exome sequencing data were analyzed. Differences in immune and stromal constituents, frequency of genomic alterations, and associations with outcomes were evaluated. Results: In our cohort, 36% of the prostate tumors were identified as CD8+ T-cell inflamed, while the remaining 64% were T-cell depleted. T-cell inflamed tumors were enriched in anti-inflammatory M2 macrophages and exhausted T-cells and associated with shorter overall survival relative to T-cell depleted tumors (HR=2.62, p<0.05). Among all prostate cancer types in the cohort, NEPC was identified to be the most immune depleted, wherein only 9 out of the 36 total NEPC tumors were classified as T-cell inflamed. These inflamed NEPC cases were enriched in interferon gamma signaling and PD-1 signaling compared to other NEPC tumors. Comparison of NEPC with SCLC revealed that NEPC had poor immune content and less mutations compared with SCLC, but expression of checkpoint genes PD-L1 and CTLA-4 was comparable between NEPC and SCLC. Conclusions: NEPC is characterized by a relatively immune-depleted tumor immune microenvironment compared with other primary and metastatic prostate adenocarcinoma except in a minority of cases. These findings may inform development of immunotherapy strategies for patients with advanced prostate cancer
Desain Tas Limbah Kaca dengan Konsep Essentiality untuk Pemberdayaan Pengrajin Manik-Manik Kaca Jombang
No full textIndonesia merupakan negara yang memiliki banyak sekali sentra kerajinan tangan yang terletak pada area pedesaan. Salah satu desa sentra kerajinan di Indonesia yang masih bertahan hingga saat ini adalah sentra kerajinan manik-manik kaca di Gudo, Jombang, Jawa Timur. Pada era 90-an, sentra kerajinan ini sangat sukses namun beberapa dekade ini mengalami penurunan pemasukan dikarenakan kurangnya inovasi serta wawasan mengenai pengembangan produknya. Untuk itu, penulis membantu mengembangkan produk-produk hasil manik-manik kaca pengrajin yang sebelumnya output produk hanya perhiasan sederhana menjadi produk yang dapat digunakan pada aktivitas sehari-hari seperti produk tas dengan menggunakan acuan konsep trend-forecasting 2020/2021 “ Essentiality”. Penulis melakukan eksplorasi material untuk mencari alternatif teknik baru yang dapat digunakan pengrajin. Lalu penulis menerapkannya pada produk baru yaitu produk tas. Selanjutnya, penulis melakukan pelatihan bersama para pengrajin guna memperkenalkan teknik eksplorasi baru dan saling bertukar pendapat bersama pengrajin, dan bersama-sama mengembangkan produk-produk menggunakan teknik baru ke arah yang lebih luas lagi. Hasil produk dari pelatihan cukup beragam antara lain produk apparel, perhiasan, home decor, bathroom set, hal ini membuktikan bahwa sebenarnya pengrajin juga dapat berinovasi secara luas.
=====================================================================================================
Indonesia is a country that has many handicraft centers located in rural areas. One of the craft center villages in Indonesia that still survives today is the glass bead craft center in Gudo, Jombang, East Java. In the 90s, this craft center was very successful but in recent decades its income has decreased due to lack of innovation and increased product development. For this reason, the author helps develop products from glass bead craftsmen who were previously only jewelry jewelry that can be used in daily activities such as bags by using the concept of forecasting the 2020/2021 trend "Essentiality". The author explores the material to find alternative new techniques that can be used by craftsmen. Then the author applies it to a new product, namely bag products. Furthermore, the authors held training with the craftsmen to introduce new exploration techniques and exchange opinions with the craftsmen, as well as jointly develop products using new techniques in a broader direction. The results of the training were quite diverse, including clothing products, jewelry, home decorations, bathroom equipment, this proves that the actual maker can also be seen widely
PRAKTIK PERNIKAHAN DINI DENGAN CARA MERARIQ DI DESA CENDI MANIK KECAMATAN SEKOTONG KABUPATEN LOMBOK BARAT
No full textEarly marriage is a marriage for teenagers under the age of 20 who should not be readinya to carry out marriage, and law no. 6 of 2019 article 7 (1) marriage is only permitted if the male party has reached the age of 19 years and party has reached the age of 19 years. Article 6 (2) to marry someone eho has not reached the age of 21 years, both parents must have permission, these two regulations are the basis for the Indonesian people to marry in order to achieve a happy, eternal and eternal household. However, there are still many practices of early marriage, one of which is in Cendi Manik Village , so this thesis examines the Praactice of Early Marriage in Cendi Manik Village, Sekotong District, West Lombok Regency by using the problem formulation: how is the practice of early marriage by merariq in Cendi Manik Village District Sekotong and how the sociology of law reviews the practice of early marriage by means of merariq in Cendi Manik Village Sekotong District West Lombok Regency.
This type of research is a qualitative research with a legal sociology with a legal sociologi approch. This research is a field research, collecting primary and secondary data by means of observation, direct intervieews and documentation. The author uses the theory of legal culture and functional structural theory..
The results of the study are: first, the practice of early marriage that occurred in Cendi Manik Village is known as the merariq custom and was kidnapped without any confluct between the two parties and was married according to the customary terms and conditions of marriage, one of the main factors in the occurrence of early marriage with merariq is cultural factors, as well as legal sociology, the people of Cendi Manik Village carry out early marriage as a social and cultural indication caused by life behavior and attitudes that influence each other
Features of circulating parainfluenza virus required for growth in human airway
No full textRespiratory paramyxoviruses, including the highly prevalent human parainfluenza viruses, cause the majority of childhood croup, bronchiolitis, and pneumonia, yet there are currently no vaccines or effective treatments. Paramyxovirus research has relied on the study of laboratory-adapted strains of virus in immortalized cultured cell lines. We show that findings made in such systems about the receptor interaction and viral fusion requirements for entry and fitnessâmediated by the receptor binding protein and the fusion proteinâcan be drastically different from the requirements for infection in vivo. Here we carried out whole-genome sequencing and genomic analysis of circulating human parainfluenza virus field strains to define functional and structural properties of proteins of circulating strains and to identify the genetic basis for properties that confer fitness in the field. The analysis of clinical strains suggests that the receptor binding-fusion molecule pairs of circulating viruses maintain a balance of properties that result in an inverse correlation between fusion in cultured cells and growth in vivo. Future analysis of entry mechanisms and inhibitory strategies for paramyxoviruses will benefit from considering the properties of viruses that are fit to infect humans, since a focus on viruses that have adapted to laboratory work provides a distinctly different picture of the requirements for the entry step of infection.IMPORTANCE Mechanistic information about viral infection-information that impacts antiviral and vaccine development-is generally derived from viral strains grown under laboratory conditions in immortalized cells. This study uses whole-genome sequencing of clinical strains of human parainfluenza virus 3-a globally important respiratory paramyxovirus-in cell systems that mimic the natural human host and in animal models. By examining the differences between clinical isolates and laboratoryadapted strains, the sequence differences are correlated to mechanistic differences in viral entry. For this ubiquitous and pathogenic respiratory virus to infect the human lung, modulation of the processes of receptor engagement and fusion activation occur in a manner quite different from that carried out by the entry glycoprotein-expressing pair of laboratory strains. These marked contrasts in the viral properties necessary for infection in cultured immortalized cells and in natural host tissues and animals will influence future basic and clinical studies
POTENSI OBJEK WISATA CURUG PUNCAK MANIK GEOPARK CILETUH SEBAGAI IDE DALAM PEMBUATAN MOTIF BATIK UNTUK KHIMAR SCARF
No full textSebagai kain dengan penuh simbol juga makna, batik tentu mempunyai motif baku yang sarat dengan makna filosofis nya, dan motif batik antara lain motif geometris, hewan, manusia, atau yang lain nya seperti lingkungan alam sekitar. Potensi objek wisata yang mempunyai ciri khas dengan keunikan nya menjadi daya tarik tersendiri yang dapat menarik hati wisatawan untuk berkunjung ke tempat tersebut, dan potesi potensi yang menarik itu juga dijadikan sumber ide dalam berkarya seni rupa, yaitu termasuk pembuatan motif batik. Adanya potensi objek wisata yang dimiliki oleh objek wisata Curug Puncak Manik Geopark Ciletuh dijadikan ide untuk berkarya seni rupa batik. Penulis membuat motif batik untuk khimar scarf dari potensi objek wisata Curug Puncak Manik Geopark Ciletuh. Tujuan dari penciptaan motif batik untuk khimar scarf ini adalah (1) Dapat mengetahui bagaimana menggembangkan ide potensi objek wisata Curug Puncak Manik Geopark Ciletuh dalam penciptaan motif batik untuk khimar scarf. (2) Dapat merealisasikan bentuk visual motif potensi objek wisata Curug Puncak Manik Geopark Ciletuh dalam penciptaan motif batik untuk khimar scarf. Setelah mendapatkan ide dari potensi objek wisata Curug Puncak Manik Geopark Ciletuh untuk sebuah karya, penulis membuat desain motif, penulis memindahkan motif tersebut pada watercolor paper dengan pewarnaan menggunakan teknik watercolor, dan proses penyelsaiaan dalam penciptaan motif batik ini yaitu dengan proses printing kain dan dijahit untuk kemudian jadilah khimar scarf. Penciptaan motif batik untuk khimar scarf ini diharapkan dapat dijadikan sumber ide dalam pengembangan pembuatan motif batik selanjutnya.;--As a fabric with full symbol also meaning, batik certainly has a raw motif that is loaded with its philosophical meaning, and batik motifs such as geometric motifs, animals, humans, or others such as natural environment. Potential tourism objects that characterize the uniqueness of its unique attraction that can attract tourists to visit the place, and the interesting potential of it is also used as a source of ideas in art work, namely including making batik motifs. There are potential tourism objects owned by the tourism object of Curug Puncak Manik Geopark Ciletuh made an idea to work the art of batik. The author makes batik motif for the khimars scarf from the potential of tourism object Curug Puncak Manik Ciletuh. The purpose of the creation of batik motifs for the Khimars scarf is (1) can figure out how to echo the idea of potential attractions of Curug Puncak Manik Geopark Ciletuh in the creation of batik motifs for the khimars scarf. (2) Can realize the visual form of motive potential of tourism object Curug Puncak Manik Geopark Ciletuh in the creation of batik motifs for khimars scarf. After getting the idea of the potential attraction attractions Ciletuh Waterfall Summit for a work, the author made a design motif, the author move the motif on watercolor paper with coloring using watercolor techniques, and the process In the creation of batik motif is by the process of printing cloth and stitched to then be a khimars scarf. The creation of batik motifs for the khimars scarf is expected to be a source of ideas in the development of the next batik motif
Micro-power Pulsed-Doppler Radar Clutter and Displacement Source Classification Dataset
No full textThis is the official dataset for the ACM BuildSys 2019 publication One Size Does Not Fit All: Multi-Scale, Cascaded RNNs for Radar Classification.
The training code for MSC-RNN can be found at https://github.com/dhruboroy29/MSCRNN
Kindly cite this work as:
@article{roy2019one,
title={One Size Does Not Fit All: Multi-Scale, Cascaded RNNs for Radar Classification},
author={Roy, Dhrubojyoti and Srivastava, Sangeeta and Kusupati, Aditya and Jain, Pranshu and Varma, Manik and Arora, Anish},
journal={arXiv preprint arXiv:1909.03082},
year={2019}
}
</pre
Gender differences in substance use and depression among caregivers
No full textTITLE: Gender differences in substance use and depression among caregivers
AUTHOR INFO
Memunat Ogunmefun
Manik Ahuja
Author Affiliations:
College of Public Health, East Tennessee State University, Johnson City, TN 37614, United States
Background: Around 20% of adults in the United States provide care for a loved one, with approximately 61% of these caregivers identifying as women. Typically, a caregiver is defined as someone who provides help and support to a family member or friend who is facing illness or disability as a result of a medical condition. Caregiving may be rewarding, but it can also cause significant psychological strain, leading to adverse consequences, such as turning to substance use to cope with stress. Increased levels of stress in caregivers can make them more susceptible to various health problems, such as depression and anxiety disorders, sleep disturbances, compromised physical health, cardiovascular disease, and substance use disorders. The aim of this study is to examine the gender differences in substance use and depression among caregivers using a nationally representative sample.
Methods: We used cross-sectional data from the 2021 Behavioral Risk Factor Surveillance System a nationally representative U.S. telephone-based survey of adults aged 18 years and extracted data for non-metropolitan/rural counties. Logistic regression analyses were conducted separately to test the association between self-identified caregiver status and three outcomes, including depression and current alcohol use. We controlled for past month’s income, race, educational status, and age. Caregiver status was identified based on providing care or assistance to a friend or family member over the last 30 days.
Results: Overall, 21.7% (n=13,653) of our participants self-identified as a caregiver, while 19.5% reported depression, past month alcohol use (48.2%), past month smoking (13.5%), and past month marijuana use (4.2%). Significant interactions were found between caregiver status and gender (p=.0001). We then stratified by gender. Among males, self-identified caregiver status was associated with higher odds of depression (OR=1.48, 95% CI, 1.41,1.55). Among females, caregiver status was associated with higher odds of depression (OR=1.48, 95% CI, 1.29, 1.39). Caregiver status did not predict alcohol use.
Conclusion: Caregiving has been known to cause psychological strain which may be associated with alcohol use and depression. According to this study, being a caregiver may contribute to depression regardless of gender, but it does not necessarily affect alcohol consumption. The gender differences observed in this study highlight the need for interventions and support programs that are tailored to meet the unique needs and challenges faced by male and female caregivers. It is important for healthcare professionals to consider caregiver status and gender when assessing mental health risk factors
Racial Disparities Associated With Colon Cancer Screening in a Nationally Representative Sample; A Cross-sectional Study
No full textTITLE: Racial disparities associated with colon cancer screening in a nationally representative sample; A cross-sectional study
AUTHOR INFO
Yorandos Tafesse MD1
Manik Ahuja PhD, MA1
Author Affiliations:
1College of Public Health, East Tennessee State University, Johnson City, TN 37614, United States
Colon cancer impacts nearly 2 million individuals in the U.S. each year. Early detection of colon cancer using colonoscopy can reduce the risk of mortality. The United States Preventive Services Task Force (USPSTF) recommends routine screening for colon cancer for all adults 50 to 75 years of age. Colon cancer screening behavior is different across a variety of predictor variables. Previous studies have identified older age, male gender, higher education, higher income, marriage, and the presence of chronic diseases to be associated with increased odds of colon cancer screening. However, less is known about the role of racial differences in screening. This study aims to determine if colon cancer screening rates are different between Whites and racial minorities in the United States controlling for potential confounders. This research can help bridge the existing gap on this topic and aid in identifying high-risk racial groups that could be targeted by future intervention strategies. We used cross-sectional data from the 2019 Behavioral Risk Factor Surveillance System, a nationally representative U.S. telephone-based survey of adults aged 18 years or older. We extracted data for adults age 50 or older (n=10,972). Logistic regression analyses were conducted to test the association between race and colon cancer screening. We also included chronic disease status, alcohol use, smoking, gender, and age in our model. Chronic disease status was coded as self-report 2 or more, 1 and 0 chronic diseases (referent), which included the summation of heart disease, hypertension, COPD, and diabetes. Overall, colon cancer screening is as follows among Whites (77.2%), Blacks (72.4%), Asian (60.1%), American Indian/Alaska Native (69.7%), and Hispanic (68.6%). Logistic regression results revealed that having 2 or more chronic diseases (OR=1.73; 95% CI 1.53,1.96), 1 chronic disease (OR=1.45; 95% CI 1.31,1.65), and female gender (OR=1.14; 95% CI 1.04,1.23) were associated with higher odds of screening. Race/ethnic minority status (OR=0.72; 95% CI 0.65, 0.81), low income (OR=0.64; 95% CI 0.57,0.70), and less than high school education (OR=0.71; 95% CI 0.59,0.84) were associated with lower odds of screening. Our research showed that racial minorities have lower odds of colon cancer screening after adjusting for gender, age, chronic diseases, income, and education status. Preventive practices should focus on increasing awareness on and availability of colon cancer screening means to racial minorities in the United States. Further research on the association between race and other screening modalities will help maximize the impacts of targeted interventions
- …
