102,073 research outputs found
A modified chest leads for minimization of ventricular activity in electrocardiograms
No full textLink to publisher's homepage at http://ieeexplore.ieee.org/A very little information of the atrial depolarization and
repolarization phase of the electrocardiogram is seen in normal and
in any abnormal ECG’s. The observation of the electrical activity
of the each atrium is critical in the case of the atrial arrthymias.
Since, the conventional 12 lead ECG configuration views the
electrical axis of the different anatomical space of the ventricles,
much larger information about the atria is not well explained. The
atrial activity seen in ECG trace is very less compared to the QRS
complex and some of the atrial phase is obscured in the large
ventricular activity. A modified chest lead system is proposed to
provide more information about the electrical activity of the atria
in normal subjects. ECG trace were recorded and analyzed
simultaneously for the subjects with the proposed modified chest
leads and the conventional bipolar limb leads in the CRO. The
amplitude of the QRS complex in conventional bipolar limb leads
was found to be 3.4V, 4.8V and 1.4V respectively and the Einthoven
triangle were satisfied. In the modified chest lead ECG, the QRS
complex was much reduced and found to be 0.6V. The duration of
the atrial P wave was found to be 0.08sec and the total atrial
complex was found to be 0.22 sec in the modified chest lead. A
negative wave was found in the PR segment which is found to be
non iso-electric and had duration of 0.14 sec claimed due to the
atrial repolarisation wave
Excited state structure and dynamics of p-benzoquinone and bromanil from time-resolved resonance Raman spectra and simulation
No full textp-Benzoquinone and its halogen substituted derivatives are known to have differing reactivities in the triplet excited state. While bromanil catalyzes the reduction of octaethylporphyrin most efficiently among the halogenated p-benzoquinones, the reaction does not take place in presence of the unsubstituted p-benzoquinone (T. Nakano and Y. Mori, Bull. Chem. Soc. Jpn., 67, 2627 (1994)). Understanding of such differences requires a detailed knowledge of the triplet state structures, normal mode compositions and excited state dynamics. In this paper, we apply a recently presented scheme (M. Puranik, S. Umapathy, J. G. Snijders, and J. Chandrasekhar, J. Chem, Phys., 115, 6106 (2001)) that combines parameters from experiment and computation in a wave packet dynamics simulation to the triplet states of p-benzoquinone and bromanil. The absorption and resonance Raman spectra of both the molecules have been simulated. The normal mode compositions and mode specific excited state displacements have been presented and compared. Time-dependent evolution of the absorption and Raman overlaps for all the observed modes has been discussed in detail. In p-benzoquinone, the initial dynamics is along the C=C stretching and C-H bending modes whereas in bromanil nearly equal displacements are observed along all the stretching coordinates
Bibliographie Hilarion G. Petzold 1958 – 2009 mit Anhang als Einführung
No full textDieses Archiv enthält die Gesamtbibliographie der Werke des Autors nebst einiger Texte „Über H. G. Petzold“ im Schlussteil der Bibliographie sowie einen Anhang mit einer Einführung in die Architektur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author and some texts about H. G. Petzold, moreover an epilogue with an introduction to the architecture of the works in its epistemological structure and composition and as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2009-petzold-h-g-gesamtbibliographie-h-g-petzold-1958-2009-updating-november2009/peerReviewedpublishedVersio
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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3346: Samuel G. Freedman, author, 2013
No full textPhotograph of author Samuel G. Freedman, at NT Daily Slash meeting in the Mayborn School of Journalism at UNT
Temperature Insensitivity and Behavioural Reduction of the Physiological Stress Response to Longline Capture by the Gummy Shark, Mustelus antarcticus.
No full textMany factors influence the physiological stress response to fisheries capture in elasmobranchs. However, the influence of sea surface temperatures (SST) and behaviour are unknown and crucial considering global fishing pressures. We investigated the effect of SST and behaviour on the physiological stress response to capture of the gummy shark, Mustelus antarcticus, and compared our results to a laboratory study using similar conditions to test whether stress responses of in situ capture are consistent with those from laboratory simulations. Capture time for 23 M. antarcticus ranged 32-241 min as measured by hook timers or time depth recorders (TDR) in SSTs ranging 12-20°C. TDR data from 13 M. antarcticus were analysed to quantify capture behaviour as the percentage of time spent moving during capture. Several physiological variables measured from blood samples obtained immediately upon the animals' landing indicated that although warmer SSTs increased metabolic rate, the stress response to capture was not exacerbated by capture duration. During capture movement occurred for an average of 10% of the time and since M. antarcticus can respire whilst stationary, restricted movement probably mitigated potential influences of increased SSTs and capture duration on the stress response. Previous laboratory findings were also shown to be indicative of in situ conditions and we thus advise that studies control for water temperature given the influence it has on variables (e.g. lactate) used to measure capture stress in elasmobranchs. We highlight the importance of seasonal water temperatures and capture behaviour when assessing the resilience to fisheries capture and the implementation of appropriate fisheries management strategies
The Right to Strike under the United States Constitution: Theory, Practice, and Possible Implications for Canada
No full textAnswering critics of the Canadian Supreme Court's judgment in B.C. Health, the author argues that the Court laid the foundation for a principled and durable doctrine protecting constitutional labour rights, one that goes directly to the heart of the matter — the inequality of workers’ power in the employment relation. In the author’s view, two paths could lead from B.C. Health to the recognition of Charter protec- tion for a right to strike: one that treats the right as an accessory to col- lective bargaining, and one that upholds the right directly on the basis of the Charter values of equality and participation. The author supports the latter approach, contending that constitutional rights should be defined in relation to fundamental values, in a way that is not contingent on time-bound or fact-sensitive assessments about the role of strikes within a particular collective bargaining regime. Although a Charter right to strike may involve the courts in difficult choices about when to defer to legislative policy decisions, and courts may lack the institutional capac- ity to deal effectively with labour law issues, the author points out that judges can look to ILO standards for expert guidance. Noting that the U.S. experience in this area might be of considerable use to Canadians, the author concludes by providing an overview of American case law concerning a constitutional right to strike.Peer reviewe
Oncogenic ALK signaling in neuroblastoma
No full textOver the last decade Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase (RTK) has been identified as a translocation partner in diverse cancer types. In tumors, where the full-length ALK RTK itself is mutated, such as neuroblastoma, the picture is less clear regarding ALKs role as an oncogenic driver. Neuroblastoma is a heterogeneous disease of the sympathetic nervous system, accounting for 10-15% of all childhood cancer deaths. A number of small tyrosine kinase inhibitors (TKIs) have been developed to inhibit ALK activity. The data acquired thus far suggests that ALK TKI mono-treatment may not be as effective solution for ALK positive neuroblastoma patients. Therefore, there is a need for combination therapy using drugs towards different targets or signaling pathways to combat the disease. The overall aim of this thesis is to identify targets in signaling pathways that can be inhibited by specific drugs, as a potential poly-therapy treatment strategy in ALK positive neuroblastoma patients.
Using an MS-based phosphor-proteomics approach, we identified STAT3 as a potential downstream target of oncogenic ALK signaling (Paper I). ALK activation of STAT3 results in increased phosphorylation of STAT3 in PC12 cells expressing a gain-of-function ALK mutation. Pharmacologic inhibition of STAT3 using FLLL32 and STATTIC resulted in decreased phosphorylation levels of STAT3 and MYCN protein and mRNA levels. This study identified STAT3 as a target of ALK signaling and showed that inhibition of STAT3 using FLLL32 and STATTIC decreases proliferation of neuroblastoma cell lines and regulates the transcription of MYCN.
In a subsequent paper, we identified ERK5 as a potential ‘druggable’ target for ALK positive neuroblastoma patients (Paper II). Inhibition of ERK5 activity, reduced proliferation of ALK positive neuroblastoma cells as well as MYCN mRNA levels. Combination of ALK and ERK5 inhibitors abrogated tumor growth and cell proliferation synergistically. Overall, this study showed that ALK activates ERK5 via the PI3K pathway and regulates MYCN transcriptionally, suggesting that targeting both ALK and ERK5 might be beneficial for ALK positive neuroblastoma patients.
In paper III, we addressed whether MEK inhibition alone or in combination with ALK inhibitor(s) has therapeutic value in a large panel of neuroblastoma cell lines. MEK inhibition alone in ALK positive neuroblastoma cells or xenografts did not abrogate cell or tumor growth. We showed that pharmacological inhibition of MEK-ERK pathway in ALK-positive neuroblastoma cells results in increased levels of activation/phosphorylation of AKT and ERK5. This feedback response is regulated by the mTOR complex 2 protein SIN1. Our results contraindicate the use of MEK inhibitors as effective therapeutic strategy in ALK-positive neuroblastoma.
Together, this study highlights the importance of full length ALK receptor signaling in neuroblastoma. Further, it shows that combination of ALK inhibitor with PI3K/Akt/mTOR/ERK5 pathway inhibitors might be a potential therapeutic treatment strategy for ALK positive neuroblastoma patients
G-Rank: Unsupervised Continuous Learn-to-Rank for Edge Devices in a P2P Network
No full textRanking algorithms in traditional search engines are powered by enormous training data sets that are meticulously engineered and curated by a centralized entity. Decentralized peer-to-peer (p2p) networks such as torrenting applications and Web3 protocols deliberately eschew centralized databases and computational architectures when designing services and features. As such, robust search-and-rank algorithms designed for such domains must be engineered specifically for decentralized networks, and must be lightweight enough to operate on consumer-grade personal devices such as a smartphone or laptop computer. We introduce G-Rank, an unsupervised ranking algorithm designed exclusively for decentralized networks. We demonstrate that accurate, relevant ranking results can be achieved in fully decentralized networks without any centralized data aggregation, feature engineering, or model training. Furthermore, we show that such results are obtainable with minimal data preprocessing and computational overhead, and can still return highly relevant results even when a user’s device is disconnected from the network. G-Rank is highly modular in design, is not limited to categorical data, and can be implemented in a variety of domains with minimal modification. The results herein show that unsupervised ranking models designed for decentralized p2p networks are not only viable, but worthy of further research.https://github.com/awrgold/G-RankComputer Scienc
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