500 research outputs found
61. Jahrestagung der DGKN 2017 mit Richard-Jung-Kolleg in Leipzig: Ein Rückblick und Ausblick
No full textDie 61. Wissenschaftliche Jahrestagung der DGKN fand vom 27.–29. April 2017 an der 1409 gegründeten Universität Leipzig statt unter der gemeinsamen Leitung der Tagungspräsidenten Prof. Ulrich Hegerl, Direktor der Klinik und Poliklinik für Psychiatrie und Psychotherapie am Universitätsklinikum Leipzig, und Prof. Stefan Zierz, Direktor der Neurologischen Klinik und Poliklinik des Universitätsklinikums Halle (Saale). Tagungsort war die in den letzten Jahren aufwendig sanierte Kongresshalle am bekannten Leipziger Zoo, die aufgrund ihrer zentralen Lage und dem bemerkenswerten Mix aus Neo-Barock, Jugendstil, Art Déco und Moderner Architektur einen feierlichen und großzügigen Rahmen für eine abwechslungsreiche Veranstaltung und vielfältigen wissenschaftlichen Austausch bot.</jats:p
Periodic motor impairments in a case of 48-hour bipolar ultrarapid cycling before and under treatment with valproate
No full textMotor impairments of psychiatric patients can be assessed with digital recordings of handwriting tasks. The investigation of patients with bipolar affective disorders differentiates intraindividual changes related to the patient's fluctuating affective states. An unmedicated 67-year-old male with 48-hour bipolar ultrarapid cycling was investigated during 8 consecutive days of ultrarapid cycling and 4 weeks later, after remission under treatment with valproate. The handwriting skills of the patient followed the same rhythmic changes of the psychopathology in the first part of the study and a steady pattern in the second phase, after remission. Therefore, it can be assumed that the handwriting skills reflect a state marker of the disease. Poorer handwriting skills on the manic days, as compared to the depressive ones, support the hypothesis of a low arousal in manic patients. Copyright (C) 2000 S. Karger AG, Basel
Facial expressions and personality: A kinematical investigation during an emotion induction experiment
No full textBackground/Aims: In order to elucidate the relationship between personality traits and expression of positive emotions in healthy volunteers, standardized personality inventories and kinematical analysis of facial expressions can be helpful and were applied in the present study. Methods: Markers fixed at distinct points of the face emitting ultrasonic signals at high frequency gave a direct measure of facial movements with high spatial-temporal resolution. Forty-six healthy participants (mean age: 40.7 years; 20 males, 26 females) watching a witty movie ('Mr. Bean') were investigated. Results: Speed of `laughing' was associated with higher scores on Zuckerman's Sensation Seeking Scale and NEO-FFI (Openness to Experience). Conclusion: Kinematical analysis of facial expressions seems to reflect sensation seeking and related personality styles. Higher speed of facial movements in sensation seekers suggests lowered serotonergic function. Copyright (c) 2006 S. Karger AG, Basel
Kinematic analysis of handwriting movements in patients with Alzheimer's disease, mild cognitive impairment, depression and healthy subjects
No full textA variety of studies have demonstrated that motor disorders, parkinsonism and extrapyramidal motor symptoms (EPMS) are common in patients with Alzheimer's disease (AD). Several studies have reported an association of EPMS with severity, progression and poor prognosis of AD. The majority of these studies used clinical assessments for the rating of EPMS. In this study, kinematic handwriting analysis was used to quantify differences in fine hand motor function in patients with probable AD and mild cognitive impairment (MCl, as an assumed initial stage of AD) compared to depressed patients and healthy controls. Both patients with MCl and patients with probable AD exhibited loss of fine motor performance. Movements of AD patients were significantly less regular than those of healthy controls. Copyright (C) 2003 S. Karger AG, Basel
Lithium-induced EEG changes in patients with affective disorders
No full textIn 12 patients with affective disorders (ICD-10: F31, F32, F33), EEGs were recorded before and after 4.4 months of lithium treatment. Effects of lithium on the EEG were analyzed by power spectral analysis controlled for vigilance. We found (1) an increase in relative power in both delta and theta band which was related to the lithium plasma level, (2) a decrease in relative alpha power especially at occipital leads and (3) a reduction of the dominant alpha frequency. The changes in relative power were more pronounced in the right hemisphere, which is in contrast to the hypothesis of a site-specific localization of lithium effects only in left anterior regions. Copyright (C) 2000 S. Karger AG,Basel
Neurochemical substrates and neuroanatomical generators of the event-related P300
No full textThe present review focuses on the current knowledge of the neurochemical processes and neuronal structures involved in the generation of P300. The increasing knowledge in this area facilitates the physiological interpretation of P300 findings as well as the link between P300 research and other research findings in biological psychiatry. Concerning the question of neurochemical substrates, the glutamatergic, GABAergic, cholinergic, noradrenergic, dopaminergic and serotonergic influences on P300 are reviewed. The knowledge of the generating structures of P300 is summarized from intracranial studies, magnetoencephalographic investigations, lesion and animal studies
Control conditions for randomised trials of behavioural interventions in psychiatry: a decision framework
No full textDeutsche Gesellschaft für Klinische Neurophysiologie
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Anwesende: Vorstand: Präsident Prof. Ulrich Hegerl; 1. Vizepräsidentin Prof. Agnes Flöel; Schatzmeister: Prof. Christian Bischoff; 1. Sekretär: Prof. Detlef Claus; Vorsitzender der Fortbildungsakademie: Prof. Helmut Buchner; Kooptiert für den Vorstand: Prof. Reinhard Dengler, Prof. Alfons Schnitzler, Prof. Otto Witte, Prof. Ulf Ziemann; AWMF-Delegate Prof. Felix Rosenow, und 26 weitere Mitglieder, insgesamt: 36 Mitglieder</jats:p
Depression und Suizidalität
No full textEven if the freedom to suicide is part of our human existence, about 90% of all suicides occur in the context of psychiatric disorders and thus in states of limited power of judgment. Depressive disorders represent the most frequent cause for suicides. Thus, optimization of medical care for depressive patients is one of the most promising strategies to prevent suicides. In the context of the `Nuremberg Alliance Against Depression' it came to an obvious reduction of suicidal acts compared to a baseline year and compared to the control region of Wurzburg. The reduction could be reached by a cooperation with GPs, multipliers such as teachers, priests, geriatric caregivers and the media, through intensive public relations work and through support of self help activities. This approach is carried forward within the Germany-wide `Alliance Against Depression' and within the `European Alliance Against Depression' ( EAAD) which is funded by the European Commission. In the last part of the article the suicide- preventive, but also the possible suicide-inducing effect of antidepressants is discussed
Depressionsbehandlung unter komplizierenden Bedingungen: Komorbidität, Multimedikation, geriatrische Patienten
No full textDieses Buch entstand aus dem Problem heraus, wie dem zeitgleichen Auftreten einer depressiven und körperlichen Erkrankung diagnostisch und therapeutisch begegnet werden soll. Dies gilt nicht zuletzt für die größer werdende Zahl älterer Patientinnen und Patienten, bei denen eine solche Komorbidität eintritt. Weitere wichtige Themen des Buches sind die Erkennung und Behandlung depressiver Störungen in der Schwangerschaft sowie die gleichzeitige medikamentöse Therapie mit ganz unterschiedlichen Substanzen bzw. Substanzklassen ("Multimedikation"). Es ist selbstverständlich, dass diese in der psychiatrischen Praxis auftauchenden Probleme sich ohne Einbeziehung der dazu erarbeiteten wissenschaftlichen Positionen nicht zuverlässig beantworten lassen. Der vorliegende Band will dementsprechend typische klinische Situationen auf dem Hintergrund des aktuellen Wissensstandes beschreiben und Therapieempfehlungen formulieren
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