112 research outputs found
Selbstassemblierte Monolagen und magnetisch strukturierte Submonolagen mit dia- und paramagnetischen Molekülen sowie Einzelmolekülmagneten auf Phthalocyanin- und Subphthalocyanin-Basis
No full textSortase-Mediated Ligation of Purely Artificial Building Blocks
No full textSortase A (SrtA) from Staphylococcus aureus has been often used for ligating a protein with other natural or synthetic compounds in recent years. Here we show that SrtA-mediated ligation (SML) is universally applicable for the linkage of two purely artificial building blocks. Silica nanoparticles (NPs), poly(ethylene glycol) and poly(N-isopropyl acrylamide) are chosen as synthetic building blocks. As a proof of concept, NP–polymer, NP–NP, and polymer–polymer structures are formed by SrtA catalysis. Therefore, the building blocks are equipped with the recognition sequence needed for SrtA reaction—the conserved peptide LPETG—and a pentaglycine motif. The successful formation of the reaction products is shown by means of transmission electron microscopy (TEM), matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-ToF MS), and dynamic light scattering (DLS). The sortase catalyzed linkage of artificial building blocks sets the stage for the development of a new approach to link synthetic structures in cases where their synthesis by established chemical methods is complicated.Xiaolin Dai and Ulrich Glebe thank Walter-Georg Tillmann, Khosrow Rahimi, Sabrina Mallmann,
Joerg Fettke, Manfred Pinnow, Andreas Bohn, Steffi Grunst, Erik Wischerhoff, and René Kalbitz for help with
analytical measurements. Tayebeh Mirzaei Garakani acknowledges the Alexander von Humboldt-Stiftung for
financial support. Part of this work was performed at the Center for Chemical Polymer Technology (CPT) unit of
DWI, which was supported by the EU and the federal state of North Rhine–Westphalia (grant EFRE 30 00 883 02)
The challenges of model based policy advice
No full textIn policy consultation, communicating model results to administration and policy makers has always proven to be a challenge for scientists. Many of the relevant preconditions for effective and successful policy advice are aggravated when results are based on the simultaneous use of a multitude of different models. This paper identifies key issues – e.g., relations to administration; correct identification of prevailing objectives of all agents involved; ability to run scenarios ‘in time’ - and discusses strategies for successful communication based on the experiences of the vTI model network. Specific attention is paid to the issue of communicating ‘conflicting’ results of different models: while often seen as a source for scientific insight, such ‘inconsistencies’ have proven to be a major obstacle for acceptance in a non-academic institutional setting. The experiences, as well as the literature, point specifically to the importance of tight linkages between modellers and policy makers, and the need to abandon decisionist or technocratic approaches of policy advice in favour of pragmatic approaches stressing the bilateral nature of communication.model network, policy advice, Agricultural and Food Policy, Teaching/Communication/Extension/Profession,
Portrait of Keysar Trad, vice-president of the Lebanese Muslim Association, Sydney, August 2003 [picture] /
No full textTitle from accompanying documentation.; Inscriptions: "Keysar Trad, Dec 2003 Glebe, Australian Lebanese Muslim (Suni) wellknown spokes person for Sheikh Al Hilali Lakem Ba Mosque NSW (Mufti), moderate Islam faction, author of books on Islam", and signed by photographer in pencil on reverse.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn3123484
Polymerization‐Induced Self‐Assembly: An Emerging Tool for Generating Polymer‐Based Biohybrid Nanostructures
No full textThe combination of biomolecules and synthetic polymers provides an easy access to utilize advantages from both the synthetic world and nature. This is not only important for the development of novel innovative materials, but also promotes the application of biomolecules in various fields including medicine, catalysis, and water treatment, etc. Due to the rapid progress in synthesis strategies for polymer nanomaterials and deepened understanding of biomolecules’ structures and functions, the construction of advanced polymer-based biohybrid nanostructures (PBBNs) becomes prospective and attainable. Polymerization-induced self-assembly (PISA), as an efficient and versatile technique in obtaining polymeric nano-objects at high concentrations, has demonstrated to be an attractive alternative to existing self-assembly procedures. Those advantages induce the focus on the fabrication of PBBNs via the PISA technique. In this review, current preparation strategies are illustrated based on the PISA technique for achieving various PBBNs, including grafting-from and grafting-through methods, as well as encapsulation of biomolecules during and subsequent to the PISA process. Finally, advantages and drawbacks are discussed in the fabrication of PBBNs via the PISA technique and obstacles are identified that need to be overcome to enable commercial application.191
Institutional Repositories als zukunftsorientiertes Instrument der wissenschaftlichen Kommunikation
No full textDie zunehmende Finanzknappheit der öffentlichen Haushalte, die technische Entwicklung und der ständig wachsende Konkurrenzkampf in Forschung und Lehre veranlassen Universitäten und andere Institutionen dazu, über neue Kommunikationsformen nachzudenken, durch die Synergieeffekte zu erreichen sind. Weltweit führen heute unterschiedliche wissenschaftliche Einrichtungen Institutional Repositories ein bzw. nutzen sie bereits. Diese Arbeit beschreibt Entwicklungen und Hintergründe, die die Einrichtung von Institutional Repositories betreffen. Darüber hinaus werden internationale Projekte zur Einführung von institutionellen Archiven erläutert und miteinander verglichen. Anschließend beleuchtet die Autorin dieser Arbeit Fragen im Zusammenhang mit der Veröffentlichung wissenschaftlicher Literatur, wie z.B. Open Access, Selbstarchivierung, rechtliche Probleme bzw. den Aufbau und das Management eines Institutional Repositories. Die Verfasserin der Arbeit entwickelt einen Vorschlag für einen Arbeitsablauf eines Institutional Repositories.The increasing budget deficits and the keen competition among research institutions, cause universities and other research institutions to consider new forms of communication. At present, scientific institutions worldwide establish institutional repositories or already use them. In this thesis current developments and background information about the implementation of institutional repositories are described. Furthermore international programs concerning the establishment of institutional archives are presented and compared. Afterwards, aspects in context with scientific literature are shown i.e., open access, self-archiving, copyright questions. Another part refers to the set-up and management of an institutional repository. The author of this thesis creates a workflow-proposal for an institutional archive
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