795 research outputs found
Interview with Ollie Zipperer Fogarty
No full textMrs. Fogarty discusses her family history (Zipperer) and that of her husband's family. She was the author of the book "They Called It Fogartyville". Interview conducted by Libby Warner
Pygmalion and Galatea, Connor Fogarty (2020) - World Premiere (2021)
No full textResearch Background:
This research involved the selection, preparation, rehearsal, workshopping and world premiere performance of a new work for Cello and Piano by Australian composer Connor Fogarty, entitled “Pygmalion and Galatea”. The work was unanimously selected as winner of the 2020 Accompanists’ Guild of South Australia Composition Award by adjudicators Umberto Clerici (piano) and Daniel de Borah (piano), who subsequently workshopped the composition with the composer before presenting a public performance.
Research Contribution:
The research represents an important new addition to the contemporary Australian classical cello & piano repertoire. Inspired by the Ancient Greek myth of Pygmalion and Galatea, Fogarty’s work explores themes of love, yearning and animation, exploiting the possibilities of the cello/piano duo through innovative textural and harmonic devices built upon the pervading idea of a rising sixth. By supporting the AGSA Composition Award, engaging with the work of budding Australian composers and providing a public platform for the winning entrant, the research also serves to promote the long-term advancement of Australian art music culture.
Research Significance
The work was publicly workshopped with the composer at the AGSA Conference on 12 June 2021 (see video link) and premiered in a public performance at Elder Hall (Adelaide) on 13 June 2021. The performance was recorded and disseminated by 5MBS Radio (see audio link).
Rehearsal Video:
https://drive.google.com/file/d/15U3-NODcR7yovxO0VvPbkCcIbfJYbAJt/view
Performance Audio: https://drive.google.com/file/d/1kkTsrTUpJpnmYDQkcaESamf4oTzXI3kf/view
AGSA Festival Flyer:
https://accompanist.org.au/2021-festival-of-collaborative-artists/No Full Tex
Ollie Zipperer Fogarty 1
No full textMrs. Fogarty discusses her family history (Zipperer) and that of her husband's family. She was the author of the book "They Called It Fogartyville"
The Association Between Fear of Falling and Fall Prevention Interventions Offered by an Occupational Therapist in a Geriatric Primary Care Setting
No full textAbstract
Date Presented 4/1/2017
This study demonstrates that occupational therapy fall prevention interventions are beneficial for improving quality of care as part of a coordinated care team within a primary care setting and should further be examined in expanded populations, settings, and interventions.
Primary Author and Speaker: Lydia Royeen
Contributing Authors: Kieran J. Fogarty, Brenda Koverman</jats:p
U-47700 and Its Analogs: Non-Fentanyl Synthetic Opioids Impacting the Recreational Drug Market
No full textThe recreational use of opioid drugs is a global threat to public health and safety. In particular, an epidemic of opioid overdose fatalities is being driven by illicitly manufactured fentanyl, while novel synthetic opioids (NSOs) are appearing on recreational drug markets as standalone products, adulterants in heroin, or ingredients in counterfeit drug preparations. Trans-3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide (U-47700) is a prime example of a non-fentanyl NSO that is associated with numerous intoxications and fatalities. Here, we review the medicinal chemistry, preclinical pharmacology, clandestine availability, methods for detection, and forensic toxicology of U-47700 and its analogs. An up-to-date summary of the human cases involving U-47700 intoxication and death are described. The evidence demonstrates that U-47700 is a potent μ-opioid receptor agonist, which poses a serious risk for overdosing and death. However, most analogs of U-47700 appear to be less potent and have been detected infrequently in forensic specimens. U-47700 represents a classic example of how chemical entities from the medicinal chemistry or patent literature can be diverted for use in recreational drug markets. Lessons learned from the experiences with U-47700 can inform scientists, clinicians, and policymakers who are involved with responding to the spread and impact of NSOs
Encephalitozoon cuniculi–associated equine encephalitis : a case report
No full textA case of encephalitis of unknown origin in the horse was investigated. Postmortem
examination findings revealed a nonsuppurative granulomatous meningoencephalitis in
the right hemisphere of the cerebral cortex. Testing for West Nile virus, equine herpes
virus, equine infectious anemia, Toxoplasma gondii, Neospora caninum, and Sarcocystis
neurona were negative. The horse had a titer for Encephalitozoon cuniculi, and sections
from the affected area of the brain tested positive for the organism using both polymerase
chain reaction (PCR) and immunohistochemistry. Amplicons generated using PCR were
sequenced, and E. cuniculi genotype II was identified. This is the first case of E. cuniculi
genotype II associated with encephalitis in the horse
Modification of Loop 1 Affects the Nucleotide Binding Properties of Myo1c, the Adaptation Motor in the Inner Ear
No full textMyo1c is one of eight members of the mammalian myosin I family of actin-associated molecular motors. In stereocilia of the hair cells in the inner ear, Myo1c presumably serves as the adaptation motor, which regulates the opening and closing of transduction channels. Although there is conservation of sequence and structure among all myosins in the N-terminal motor domain, which contains the nucleotide- and actin-binding sites, some differences include the length and composition of surface loops, including loop 1, which lies near the nucleotide-binding domain. To investigate the role of loop 1, we expressed in insect cells mutants of a truncated form of Myo1c, Myo1c1IQ, as well as chimeras of Myo1c1IQ with the analogous loop from other myosins. We found that replacement of the charged residues in loop 1 with alanines or the whole loop with a series of alanines did not alter the ATPase activity, transient kinetics properties, or Ca2+ sensitivity of Myo1c1IQ. Substitution of loop 1 with that of the corresponding region from tonic smooth muscle myosin II (Myo1c1IQ-tonic) or replacement with a single glycine (Myo1c1IQ-G) accelerated the release of ADP from A.M 2?3-fold in Ca2+, whereas substitution with loop 1 from phasic muscle myosin II (Myo1c1IQ-phasic) accelerated the release of ADP 35-fold. Motility assays with chimeras containing a single ?-helix, or SAH, domain showed that Myo1cSAH-tonic translocated actin in vitro twice as fast as Myo1cSAH-WT and 3-fold faster than Myo1cSAH-G. The studies show that changes induced in Myo1c via modification of loop 1 showed no resemblance to the behavior of the loop donor myosins or to the changes previously observed with similar Myo1b chimeras
The Prospects of gene therapy.
No full textConference held May 24-26, 1971; sponsored by the National Institute of Neurological Diseases and Stroke and the John E. Fogarty International Center for Advanced Study in the Health Sciences.Mode of access: Internet
Corrigendum to “Accumulation and potential for transport of microplastics in stormwater drains into marine environments, Perth region, Western Australia” [Mar. Pollut. Bull. 168 (2021) 112362]
No full textThe authors regret that the original manuscript failed to appropriately acknowledge all sources of intellectual and technical contribution, which warrant co-authorship. Dr Mark J Hackett (School of Molecular and Life Sciences, Curtin University, Bentley 6102 WA, Australia) is now recognised as a co-author of this manuscript with respect to intellectual input into the design of ATR-FTIR experiments and interpretation of the ATR-FTIR spectra. Dr Hackett is also recognised as the sole co-author responsible for training the first author of this paper in the use of ATR-FTIR research equipment. The ATR-FTIR equipment used for this study is housed within the School of Molecular and Life Sciences at Curtin University, and all authors gratefully acknowledge Curtin University for providing access to this equipment. The authors would like to apologise for any inconvenience caused. Natasha Lutz: Conceptualization, Methodology, Software, Data curation, Investigation, Formal analysis, Visualization, Writing – original draft, Writing – review & editing. James Fogarty: Data curation, Formal analysis, Methodology, Writing – review & editing, Supervision. Andrew Rate: Conceptualization, Methodology, Writing – review & editing, Supervision. Mark J. Hackett: Investigation, Data curation, Visualization
Advancing Health Research in Humanitarian Crises
No full textAUTHOR AFFILIATION: Amit Mistry, Fogarty International Center, National Institutes of Health (NIH), United States, [email protected] media can be accessed here:
http://streaming.osu.edu/knowledgebank/PREA/PREA_Session7A_Mistry_20190325.mp4This presentation identifies the mission of the Fogarty Center at the National Institutes of Health. Within this, the Advancing Health Research in Humanitarian Crises program has been initiated recently. Specific projects within this program will be described, as well as resources and funding streams within Fogarty. Research ethics is an important cross-cutting strand across these projects
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