10 research outputs found
Su un caso di avvelenamento da paraquat: studio comparativo tra aspetti tossicologici ed anatomo-patologici
No full textReactive glioma in intracranial sarcoma ('sarcoglioma'). Histology, electron microscopy and immunohistochemistry of two additional cases.
No full textThe clinicopathologic features of 2 cases of sarcoglioma are described. This rare type of mixed brain tumor is composed of a central core of sarcoma with peripheral distribution of gliomatous elements with gradual transition from reactive to neoplastic astrocytes. The immunohistochemical features showed a strict positivity to glial fibrillary acidic protein only in glial cells, a positivity to vimentin prevalently in sarcomatous cells, whereas the factor VIII-related antigen was negative in astrocytes as well as in sarcomatous cells. The different origin of two neoplastic components is demonstrated well by an ultrastructural study. The morphological observations together with an adequate clinical setting contribute to separate this specific entity from other mixed brain tumors
Tonsillite cronica e vegetazioni adenoidi: ricerche istomorfologiche ed immuno- istochimiche
No full textRelationship between functional imaging and immunohistochemical markers and prediction of breast cancer subtype: a PET/MRI study
No full textpurpose: the aim of this study was to determine if functional parameters extracted from the hybrid positron emission tomography/magnetic resonance imaging (PET/MRI) correlate with the immunohistochemical markers of breast cancer (BC) lesions, to assess their ability to predict BC subtype. methods: this prospective study was approved by the institution’s Ethics Committee, and all patients provided written informed consent. a total of 50 BC patients at diagnosis underwent PET/MRI before pharmacological and surgical treatment. For each primary lesion, the following data were extracted: morphological data including tumour-node-metastasis stage and lesion size; apparent diffusion coefficient (ADC); perfusion data including forward volume transfer constant (Ktrans), reverse efflux volume transfer constant (Kep) and extravascular extracellular space volume (Ve); and metabolic data including standardized uptake value (SUV), lean body mass (SUL), metabolic tumour volume and total lesion glycolysis. Immunohistochemical reports were used to determine receptor status (oestrogen, progesterone, and human epidermal growth factor receptor 2), cellular differentiation status (grade), and proliferation index (Ki67) of the tumour lesions. correlation studies (mann–whitney U test and spearman’s test), receiver operating characteristic (ROC) curve analysis, and multivariate analysis were performed. Results: Association studies were performed to assess the correlations between imaging and histological prognostic markers of BC. Imaging biomarkers, which significantly correlated with biological markers, were selected to perform ROC curve analysis to determine their ability to discriminate among BC subtypes. SUVmax, SUVmean and SUL were able to discriminate between luminal A and luminal B subtypes (AUCSUVmean = 0.799; AUCSUVmax = 0.833; AUCSUL = 0.813) and between luminal A and nonluminal subtypes (AUCSUVmean = 0.926; AUCSUVmax = 0.917; AUCSUL = 0.945), and the lowest SUV and SUL values were associated with the luminal A subtype. kepmax was able to discriminate between luminal A and luminal B subtypes (AUC = 0.779), and its highest values were associated with the luminal B subtype. Ktransmax (AUC = 0.881) was able to discriminate between luminal A and nonluminal subtypes, and the highest perfusion values were associated with the nonluminal subtype. In addition, ADC (AUC = 0.877) was able to discriminate between luminal B and nonluminal subtypes, and the lowest ADCmean values were associated with the luminal B subtype. Multivariate analysis was performed to develop a prognostic model, and the best predictive model included Ktransmax and SUVmax parameters. Conclusion: Using multivariate analysis of both PET and MRI parameters, a prognostic model including Ktransmax and SUVmax was able to predict the tumour subtype in 38 of 49 patients (77.6%, p < 0.001), with higher accuracy for the luminal B subtype (86.2%)
Genome-wide microRNA expression profiling in placentas from pregnant women exposed to BPA
No full textBisphenol A (BPA) is an environmental compounds is known to possess endocrine disruption potentials. Bisphenol A has epigenetic effects as deregulated expression of microRNAs; such epigenetic marks can induce up/down alterations in gene expression that may persist throughout a lifetime. Bisphenol A (BPA) exposure has been documented in pregnant women, but consequences for development of offspring after BPA exposure during pregnancy are not yet widely studied. Therefore, the aim of this study was to gain a comprehensive understanding of microRNAs changes in the placenta transcriptome from pregnant women subjected to therapeutic abortion for fetal malformation and correlate the impact of gestational exposure to BPA on these developmental changes
Relationship between functional imaging and immunohistochemical markers and prediction of breast cancer subtype: a PET/MRI study
No full textPurpose: The aim of this study was to determine if functional parameters extracted from the hybrid positron emission tomography/magnetic resonance imaging (PET/MRI) correlate with the immunohistochemical markers of breast cancer (BC) lesions, to assess their ability to predict BC subtype. Methods: This prospective study was approved by the institution’s Ethics Committee, and all patients provided written informed consent. A total of 50 BC patients at diagnosis underwent PET/MRI before pharmacological and surgical treatment. For each primary lesion, the following data were extracted: morphological data including tumour-node-metastasis stage and lesion size; apparent diffusion coefficient (ADC); perfusion data including forward volume transfer constant (Ktrans), reverse efflux volume transfer constant (Kep) and extravascular extracellular space volume (Ve); and metabolic data including standardized uptake value (SUV), lean body mass (SUL), metabolic tumour volume and total lesion glycolysis. Immunohistochemical reports were used to determine receptor status (oestrogen, progesterone, and human epidermal growth factor receptor 2), cellular differentiation status (grade), and proliferation index (Ki67) of the tumour lesions. Correlation studies (Mann–Whitney U test and Spearman’s test), receiver operating characteristic (ROC) curve analysis, and multivariate analysis were performed. Results: Association studies were performed to assess the correlations between imaging and histological prognostic markers of BC. Imaging biomarkers, which significantly correlated with biological markers, were selected to perform ROC curve analysis to determine their ability to discriminate among BC subtypes. SUVmax, SUVmean and SUL were able to discriminate between luminal A and luminal B subtypes (AUCSUVmean = 0.799; AUCSUVmax = 0.833; AUCSUL = 0.813) and between luminal A and nonluminal subtypes (AUCSUVmean = 0.926; AUCSUVmax = 0.917; AUCSUL = 0.945), and the lowest SUV and SUL values were associated with the luminal A subtype. Kepmax was able to discriminate between luminal A and luminal B subtypes (AUC = 0.779), and its highest values were associated with the luminal B subtype. Ktransmax (AUC = 0.881) was able to discriminate between luminal A and nonluminal subtypes, and the highest perfusion values were associated with the nonluminal subtype. In addition, ADC (AUC = 0.877) was able to discriminate between luminal B and nonluminal subtypes, and the lowest ADCmean values were associated with the luminal B subtype. Multivariate analysis was performed to develop a prognostic model, and the best predictive model included Ktransmax and SUVmax parameters. Conclusion: Using multivariate analysis of both PET and MRI parameters, a prognostic model including Ktransmax and SUVmax was able to predict the tumour subtype in 38 of 49 patients (77.6%, p < 0.001), with higher accuracy for the luminal B subtype (86.2%)
Cardiac tamponade and heart failure due to myopericarditis as a presentation of infection with the pandemic H1N1 2009 influenza A virus.
No full textWe describe a fatal case of myopericarditis presenting with cardiac tamponade in a previously healthy 11-year-old child. Pandemic H1N1 2009 influenza A virus sequences were identified in throat and myocardial tissues and pericardial fluid, suggesting damage of myocardial cells directly caused by the virus
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No full textTHE PAH V PALO ALTO TIMTS
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SAN JOSE PLANS
BIG CELEBRATION
Mavis, shoot,
Kllle Club held Ita
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Sunday. Oliver
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teas* 'I Wilt. Iw.li
14 s.. ;,( Hi,, \mltl. lllttll
l liK-k in thr ArteriH«.|
. \MI *>
M THK
ur Ho-
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Miss laorkey. principal. Will open
August 19th at 1121 Ilryant street.]
with the following teachers tni
charge: Mlsa IHicb waa ow-
!rl.k\ wind during
■ shoot.
ractlcing hard
4l an-.
Ba
l.iwn ..".i-ruilK'UI Pi>w,llurn.
nhur Itanstord Kli i
ItUsd on the st
today for the Philip
b* iui|ili'>«-il on the 1'nlle.l'
ted State* goditlc survey In the1
ttds snd will spend four years In
work He la the son of Mrs. John-
..f SOI Waverley
S4 ll- V.011 Phi lletn Kappn for'
> scholarship In the Stanford de-j
... i. <■; Nnlogv, Mr KiYfcbi-r
England to study '
tod
and
m cottage, all moderni
h> aUon. thre* blocks from de-
I'rlce. 0,000.
>iv-r<toni .cottage, flvs blocka from
de.iot, all modern, with rear hous*
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For , $9*0 to
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10 cents a week.
loe-rchniitM^.. -l..x*t io l»ke place s'
I Mai SeptemlMT. B
i.'l dollars will be distributed
winning marksmen of the
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in past large shooting contests.
■ \
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LOTS IN TOWN
Bob ■
th several One tress, mmh« frontage, YVYbster near t
only .... tW.»K»»
louxii: i-
.ood i>
!. Webster nesr Chan:.: p cheap and
IT... »!...*.►.)*
;•**• near Lytton This Is the choicest All X
.,,* WaMuiX
Palo Alto Realty Co.
J
HIS V. 11YXUKK AMI H F IMM.. Managrea. *
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HETT1XUI R ii;i:m:\ts
(.WEI. TO THE M Won
Ourlag th.' in.-.'Ilk ,.f ihe (run
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. cn*.i| la nf mulinK'iu.i. and Is en-
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.tfttf he
unn.!.':. ■
nil of
par-
vie In Hi
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gehw..
Will
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the const
An-
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gvle
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du
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Man Zan Pile Remedy com**^ put
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Deutschland am Scheidewege
No full textAdolf Bolliger was a Swiss theologian and philosopher. This pamphlet contains sermons written by Bollinger, then a pastor in Neumünster for his Swiss parishioners, calling on them to support Germany in its war efforts. Sermon titles include, "The way to peace and the obstacles in the way," "The true nobility of the German nation - and others," "The rescue," "The fulfillment," "The call of atonement by a giant," "The need for the Swiss and aiding German." The sermons are hastily thrown together in the pamphlet, with no apparent rhyme or reason to their placement. There is an air of desperation to the whole production. Bollinger\u27s main stance seems to be that although Germany is not all that great, it looked like Americans might help win the war and then takeover once the war was won. 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(intiat\u27fen biit Du 1D1“11\u27Diger Rabbi ‘31111Mi, abgeD1111fl ineiier rl‘reDiger 1211101110: @} iii 1111111 111105 id)011 Dage‘meien. 1111D eg gibt \?ie11e»; unter Der €01111e. 311%re1\u271=!1101051 i11111D 1111 ®e3e111ber 1111T ein gema1tiger Sieger Dein 1111i101\u27e1r 111 111111De11 übten eriticfenDen Q%1\u27iegten gegeniiber; 1111D Der leer bie1[eiebt eridn‘int mir Die Sache Darum 1111erbiirt‚ mei! id) Die ‘Tßirfiidfieit 11111)1 genügenD 11berirbane. 311 11111111 11111 bie1[eid>t anDe11ten, Da?» an Der f?r011t immer 11011) iiegreiebe ®e11t1\u27db1anD fönne Inirtid1 11ft1111) man mehr Dur1bba1ten 0Der iebe D0d) Den 9111ge11b11rf De5 Qiid)tiiiebrfbnnene in eriebreäenDe Qiäbe geriieft. ‘3d) gtaube an Die1\u27e Qiiii)e nicht. ‘2111 ‘Be1\u27iegte ite111e Die ‘BeDingungen fiir Den ‘1Üaiiena meine pein1iebe *T1aebfrage ergibt immer nur, Dai; itiI[itanD 1111D ,?rieDen, gar 11i1111 beid)eiDem 1111D Der Sieger nabm Dieie1ben im 10e1\u27e11111d>e11 1111. 911 1111111 Daß iei gar nicht? 1111erbbrte5. 3er Kern Der 6aibe iei D0cb politiid)e 3‘111gbeit De9 ‘l‘11erbnnbeä, ®e11tieb1anD [eiDet‚ 10ie e»2aft= lich nicht 511 he51ningen. R‘ann fein, fagft Dit. fiber Öfterreidt la 11 11 nicht meth €eine \?Iiittel finD verbraucht, e«3 ift tnirtfchaftlid1 erf1hbpft; e«3 m 11 f; Drum ‚frieDen machen 11nD Den ftarfen \11\1ffenhrnDer in Den ab auch noch fo 11nhnrteilhaften ,?rieDen mithinein= reif3en. — Sd) 11rteile: (\3etnif; leiDet Öfterreidt fehmer. über man einem ‘]Iid)t111ehi‘fbiiiien i’ann Dmh lanm Die 9QeDe fein. 63ehbrt Doch Dad reiche, fr1nhthare QicferlanD Ungarn mit 311 Öfterreid1? “liegt ihm Dmh Die im Rrieg geöffnete reiche 5%r11l‘ammer \)(111111\u27i11i1‘11 näher, al5 fie ®e11tfd)lanD liegt! 11nD wenn Der ;YrieDe mit ‘R11fglanD perfeit tvirD, ift Der ?5eg Der 3rachtfchiffe non 9Deffa nach Der ®1\1111111111i11D111111 11nD meiterhin nach q35ien nicht fa Weit. 3t‘11r3, Der 6011DerfrieDe befeitigt Da»3 €d)li11itiifte Don Öfterreidt»3 inirtfchaftlidher *?Iot, 11nD ma»3 Damm Der €miDer= frieDe nicht befeitigt, Daß erleDigt ®entfd>lanD»3 °Zad)= barfahaft 11nD ijilfébereitfchaft. -‘Qur3, ich fann\u27é nicht glauben, Daf; Die mirt= fchaftliche “Not Die beiDen ijauptmüchk Dee *13ier= bunDé 3mang, am %eihnadfiéttag 1917 in *Breft= L’itptnéf Die allgemeine rieDen gmang. 6513 in nicht fo. “über wenn? fo wäre, fonnte Ö_QCf) ein 3)ip_lotnat Dritter (bitte im borauéä an Den ‚_y111gern abgahlen, Daf3 Die CBitte 11nnüh bleiben, ia fchaDltch tmrfen muf3te mie ieDe\u275 frühere S}rieDenéä= angebot. ®e1‘ 12. ©e3ember 1916, Der 19. Suli 1917 7 ‚_ 11nD noch ein paar Diefer fchtnar3en Sage mirften bei Der 63e1111"1t511erfaffnng Der @ntenteherren ferneilen fi», Daf3 fie förmlich anflebten, fa a11ffauch3ten: „tha, Die (begner pfeifen auf Dem let5ten Boch. ‘I3ereinigen wir 11115 „zur [elften ‘2lnftrengnng, Damit wir ihnen 11nD 3umal Den ®entfchen Dollenb\u27ei Den (baraué machen 11nD 11nfere beifge Rache fühlen! ®ieömal hat Dasö angebot bzw. Die ‘Bitte um S?rieDen tmnnöglich nach fataler gemirft alé früher. Sn (€nglanD, Daé im %ierberbanb nach wie bar ton= angebenD 11nD entfcheibenb ift, war ein mächtiger S}rieDenötnille im (Entftehen 11nD *Tßachfen begriffen. Q”(icht t1erblenDet 11nD Durch Den %licf nach Den 130: gefen 11nD Dem *Rhein nicht hhpnotifiert wie Die Wrangofen, fagten fich fluge (inglänDer nach Dem 311fa1nmenbrnch *Rnfalanbél\u27 11nD Der @inleitung Der Cl“ßaffenftillftanDéberhanDlnngen: 8aben mir mit ijilfe “Ruf3lanbé 11nD feiner ?üillionenheere nicht fiegen fönnen, merDen Inir’éä nad) Dem 811fammenbruch *Ruf3= lanD5 noch tveniger bermbgen; leerifa mirD Den ‘21116fall nimmer Decfen, um fo meniger, Da bei Der inachfenben €chiffiärautnnot feine 5eere 11nD Die anDeren unentbehrlichen 23ilfémittel binnen nüt3licher $rift nicht hergefchafft inerDen fönnen. 91115 folcher C6timmung herauä fam (€nDe Qtobember Der ‘Brief eineß mächtigen Qllanneé‚ Des? QorD Qan8Domne; be= DeutenDe 3eitnngen begrüßten ihn; ja, esä fprach biele6 Dafür, Daf3 8lohD (beorge felbft Dahinter ftanD, trnhDem er öffentlich au8 mehr alé einem (5r11nDe Den %rief feineé 5%llegen ablehnte. R‘ur3, bieleé fprach Dafür, Daf3 (?nglanD Demnächft mürbe fei 11nD Dem %ierbunb Die SjrieDenähanb entgegenftrecfen merDe. “über nun fam Der ?Beihnachtßtag 1917 mit Der fchtnc\u27ichlichen 63eneralber3ichtéfriebenéofferte Der ©ieger: ®eiD umfchlungen, 9Hillionen! llnfern S?uf5 Der gan3en °83elt! ‘ll3ir, Die C5ieger, mollen für alle H !) “Blutnbfer De»3 11115 anfgeni\u27Wigten _.R‘1\u27i1‘geé Hi1‘hlfl, feine Giitfdn\u27iDigniig 1111D feinen 3111; breit ernber1en betnmmt meine Stimme aiö *l‘sre\u27ifibent mm 11topien 1111D Warragnnien.) ® reine5 (S3efd1ent\u27 feiner ®nabe befchert hat, in Diefen fehreefiid1en Krieg führte. 29115 in (€urbpa berichte *Reeht 1111D Die ?3f[ic5f‚ ÖiC 50i[ingen CBerträge 311 berteibigen, gtnang 1hnen 305 Schwert in Die SjanD. (?8er’éä ginnbt. Rrieg53iei meDer Die *Berieisnng ®eutfehianbéunfch feine»5 111enfchenfrennbIichen 6er3ené, Daf, ieneéerf3eug Der gefährlidwn Qintntratia‘ De5 preuf3ifchen 9Hititari5mna fein. *31iidi 11mnDert nur‚_ Daf3 Der engiifche SaufenDtiinftier Öfterreidf. Demut e?> noch mehr R*raft geminne, nid)t 1111111 Die “_?lmpntation feiner ferbo=frmttifdw1 i’anthridw DD1\u27= @re1ht 11nD Deren 3uteiiung an Da»5 Rimigreid1 werbren ai; geredht€ (ßenngtnnng fnrDert. 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