2,107 research outputs found
Upregulation of cyclooxygenase-2 by motorcycle exhaust particulates-induced reactive oxygen species enhances rat vascular smooth muscle cell proliferation
No full textThe Impact of strategic implementation on the employees and contractors of the Hewlett-Packard Company.
No full textConducted within the global corporation of the Hewlett-Packard Company, (HP),this research examines employee and contractor responses to strategic implementation. The research environment is a relatively small UK group withinthe corporation that has continuously experienced significant change as new strategies were implemented. Employee and contractor responses to three separate cycles of change are analysed together with data drawn from the wider corporation by using a psychological contract framework, semi-structured interviewing, a research diary and secondary data from the literature and electronic sources. The research is essentially qualitative but draws on quantitative data where appropriate. A case study approach within an action research paradigm is the chosen methodology to allow consideration and triangulation of multiple sources of data relevant to the natural workplace setting. The research has confirmed a change from old or original psychological contracts to new contracts where employees and contractors are more insecure in, and more cynical of, their employment. This change is perceived as a
violation of their psychological contract and is causing employees and contractors to adopt a more mercenary approach to their employment with HP. The special bond between HP and its employees generated by the values and
egalitarian working environment created by its founders has been broken by new leadership. Acquisition of the Compaq Computer Company has further impacted employees and contractors resulting in declining morale and increasing scepticism about its proposed benefits. Indeed the very legitimacy of the acquisition and the leadership of HP are being questioned as HP changes to a new form. According to the founders, the values established that made HP successful in its first fifty years were expected to continue for at least another fifty years. This research shows how changing these values has collectively impacted
employees and contractors resulting in a major threat to the continuing existence of HP in its present form
Motorcycle exhaust particulates enhance vasoconstriction in organ culture of rat aortas and involve reactive oxygen species.
No full textbeta-Lapachone reduces endotoxin-induced macrophage activation and lung edema and mortality.
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Simultaneous determination of thymidylate and thymidine diphosphate by capillary electrophoresis as a rapid monitoring tool for thymidine kinase and thymidylate kinase activities
No full text[[abstract]]A simple and rapid capillary electrophoretic method was developed for the simultaneous determination of thymidylate (TMP) and thymidine 5 '-diphosphate (TDP) in enzyme assays without using radioactive-labeled substrates. Prior to electrophoretic separation, addition of acetonitrile and sodium chloride to the assay solution and brief centrifugation are recommended for the purpose of sample cleanup and sample stacking. The separation of micromolar TMP and TDP from millimolar adenosine 5 '-triphosphate (ATP) was performed at 25 degrees C using sodium tetraborate as the background electrolyte. Under the optimal condition, a good separation with high efficiency was achieved in 6 min. Several parameters affecting the separation were studied, including the pH of electrolyte, the applied voltage, and acetonitrile-salt sample stacking. The fronting of the ATP peak resulting from the interference of magnesium ion in the enzyme assay buffer was suppressed by the addition of sodium ethylenediaminetetraacetate to the sample solution. Using deoxyadenylate as an internal standard, the linear range of the method was 5-200 mu m, and the concentration limits of detection of TMP and TDP were 2.6 and 3.8 mu m, respectively. Application of the proposed method for simultaneous determination of TMP and TDP in enzyme assays was demonstrated by the activity assays of thymidine kinase and thymidylate kinase from white spot syndrome virus. This is a sensitive, nonradioactive method for thymidine kinase and thymidylate kinase assays.[[note]]SC
Evolution of the use, effectiveness and safety of bismuth-containing quadruple therapy for Helicobacter pylori infection between 2013 and 2021 : results from the European registry on H. pylori management (Hp-EuReg)
No full textPublisher Copyright: © Author(s) (or their employer(s)) 2025.background Bismuth quadruple therapies (BQTs) including bismuth, a proton pump inhibitor (PPI) and two antibiotics have been shown to be highly effective for treating Helicobacter pylori infection even in areas of high bacterial antibiotic resistance. Objective To describe the time trends of use, effectiveness and safety of BQT in Europe using the European Registry on Helicobacter pylori Management (Hp-EuReg). Design Patients registered in the Hp-EuReg from 2013 to 2021 who had received BQT were included. The regimens prescribed, the number of eradication attempts, effectiveness, adherence and safety were analysed. The effectiveness was assessed by modified intention to treat (mITT). Time-trend and multivariate analyses were performed to determine variables that predicted treatment success. results Of the 49 690 patients included in the Hp-EuReg, 15 582 (31%) had received BQT. BQT use increased from 8.6% of all treatments in 2013 to 39% in 2021. Single-capsule BQT—containing bismuth, metronidazole and tetracycline—plus a PPI (single-capsule BQT, ScBQT) was the most frequent treatment mode (43%). Schemes that obtained an effectiveness above 90% were the 10-day ScBQT and 14-day BQT using tetracycline plus metronidazole, or amoxicillin plus either clarithromycin or metronidazole. Only ScBQT achieved above 90% cure rates in all the geographical areas studied. Using the ScBQT scheme, adherence, the use of standard or high-dose PPIs, 14-day prescriptions and the use of BQT as first-line treatment were significantly associated with higher mITT effectiveness. Conclusion The use of BQT increased notably in Europe over the study period. A 10-day ScBQT was the scheme that most consistently achieved optimal effectiveness.Peer reviewe
Direct numerical simulation of the turbulent flow around an airfoil using spectral/HP method
No full textSince the accuracy of the widely used Reynolds Averaged Navier Stokes (RANS) approach is limited simulating turbulent flow separation on airfoils, we applied a spectral/hp element method to predict the turbulent flow separation at an airfoil for an angle of attack of 12°. The spectral/hp approach allows to solve the incompressible Navier-Stokes equation with spectral accuracy on unstructured grids by means of Direct Numerical simulation (DNS). Here we present first results we obtained from DNS of the flow around a fx79-w151a airfoil section for a low Reynolds Number = 5000
Simultaneous determination of thymidylate and thymidine diphosphate by capillary electrophoresis as a rapid monitoring tool for thymidine kinase and thymidylate kinase activities
No full text[[abstract]]A simple and rapid capillary electrophoretic method was developed for the simultaneous determination of thymidylate (TMP) and thymidine 5 '-diphosphate (TDP) in enzyme assays without using radioactive-labeled substrates. Prior to electrophoretic separation, addition of acetonitrile and sodium chloride to the assay solution and brief centrifugation are recommended for the purpose of sample cleanup and sample stacking. The separation of micromolar TMP and TDP from millimolar adenosine 5 '-triphosphate (ATP) was performed at 25 degrees C using sodium tetraborate as the background electrolyte. Under the optimal condition, a good separation with high efficiency was achieved in 6 min. Several parameters affecting the separation were studied, including the pH of electrolyte, the applied voltage, and acetonitrile-salt sample stacking. The fronting of the ATP peak resulting from the interference of magnesium ion in the enzyme assay buffer was suppressed by the addition of sodium ethylenediaminetetraacetate to the sample solution. Using deoxyadenylate as an internal standard, the linear range of the method was 5-200 mu m, and the concentration limits of detection of TMP and TDP were 2.6 and 3.8 mu m, respectively. Application of the proposed method for simultaneous determination of TMP and TDP in enzyme assays was demonstrated by the activity assays of thymidine kinase and thymidylate kinase from white spot syndrome virus. This is a sensitive, nonradioactive method for thymidine kinase and thymidylate kinase assays.[[note]]SC
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