1,095,962 research outputs found
Long-term safety and effectiveness of natalizumab treatment in clinical practice: 10 years of real-world data from the Tysabri Observational Program (TOP)
No full textOBJECTIVE: The Tysabri Observational Programme (TOP), which began >10 years ago, is an open-label, multinational, prospective observational study evaluating the long-term safety and effectiveness of natalizumab in relapsing-remitting multiple sclerosis patients. METHODS: These data provide a 10-year interim analysis of safety and effectiveness in TOP. Annualised relapse rates (ARRs) and disability progression/improvement were analysed using the Poisson model and the Kaplan-Meier method, respectively. Analyses included patients on natalizumab and those who discontinued natalizumab but remained in TOP. RESULTS: As of November 2017, TOP included 6148 patients. Overall, 829 patients (13.5%) experienced ≥1 serious adverse event (SAE), with infection the most common (4.1%). Fifty-three patients (0.9%) had confirmed progressive multifocal leukoencephalopathy. SAE data were consistent with natalizumab's known safety profile; no new safety signals were identified. A total of 3210 patients (52.2%) discontinued natalizumab; 2117 (34.4%) withdrew from TOP. Median time on natalizumab was 3.3 (range 0-11.6) years; median follow-up time was 5.2 (range 0-10.8) years. The on-natalizumab ARR was 0.15, a 92.5% reduction from the year before initiation. Ten-year cumulative probabilities of disability worsening and improvement were 27.8% and 33.1%, respectively. On-natalizumab ARRs were similar between patients who discontinued or remained on natalizumab, suggesting limited attrition bias. CONCLUSIONS: Since the TOP 5-year interim analysis (December 2012), cohort size (6148 vs 4821), median exposure (3.3 vs 1.8 years) and median follow-up time (62 vs 26 months) have increased. This 10-year interim analysis further supports the robust real-world effectiveness and well-established safety profile of natalizumab. TRIAL REGISTRATION NUMBER: NCT00493298
Study of the cosmic ray primary composition at E0 ~ 1000 TeV by EAS-TOP and MACRO at Gran Sasso
No full textAn analysis of the coincident deep underground muon data and of the e.m. component of Extensive Air Showers (EAS) as measured by the MACRO and EAS-TOP experiments at Gran Sasso is presented. Constraints on the primary cosmic ray composition are obtained, with the use of an interaction model that is based on collider data. The possibility of extrapolating the directly measured energy spectra to our energy range is tested
Floral Icicle Top
No full textFloral top;. Maker: Icicle - from the The Betty Smithers Design Collection at Staffordshire University.
Code archive for the article 'Predictive Theory of Mind Models Based on Public Announcement Logic'
No full text<p>This archive contains the Python code, R code, and data used in the article:</p>
<p>Predictive Theory of Mind Models Based on Public Announcement Logic</p>
<p>Dynamic Logic. New Trends and Applications. DaLí 2023.</p>
<p>Jakob Dirk Top, Catholijn Jonker, Rineke Verbrugge, Harmen de Weerd</p>
Black Asymmetrical Top
No full textBlack asymmetrical top; - from the The Betty Smithers Design Collection at Staffordshire University.
National Journal of Young Investigators (JYI)
No full textOver the past year, more than 50 undergraduates from around the US have collaborated to establish the National Journal of Young Investigators (JYI), "a faculty and student reviewed, peer edited and published, national journal" of science and engineering. Designed to showcase undergraduate research and serve as a hub for up-and-coming scientists, JYI's staff is composed entirely of undergraduate students from academic institutions across the US. The journal's scientific articles are organized in three subject areas: Physical Sciences and Mathematics, Biological and Biomedical Sciences, and Basic Engineering Sciences. The full text of current articles may be viewed online, and interested contributors will find instructions for article submissions on-site
Silver Evening Top
No full textSilver evening top; short sleeves and scoop neck. Maker: Beaufaire - from the The Betty Smithers Design Collection at Staffordshire University.
Tea Towel Top
No full textTea Towel top; cropped, with white, green and blue diagonal stripes. Short sleeves, boat neck. Finsihed with bias binding. - from the The Betty Smithers Design Collection at Staffordshire University.
Triage Decision-Making by Welfare Fraud Investigators
No full textTwo studies explored triage decision-making in a welfare fraud investigation, specifically decisions concerning what evidence to collect when deciding whether to pursue a case to prosecution or just to issue a warning. An observational study revealed that triage decisions appear to be determined by subjective estimates of the ease of evidence collection, and that these estimates are influenced by complexity of mapping evidence onto fraud types. This hypothesis was explored in an experimental study of investigators, managers, and students choosing evidence to inform triage decisions for cases that varied according relevance and complexity. Students’ selections were unaffected by the nature of the case. In contrast, with a simple fraud case, investigators and managers tended to select evidence to support a prosecution decision, but with a complex fraud case they selected evidence that supported comparison of prosecution and warning decisions. The results demonstrate flexible expertise in choosing what evidence to sample
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