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Nuovo metodo di fissaggio per i materiali protesici sperimentato su modello animale.
No full textNuovo metodo di fissaggio per materiali protesici sperimentato su modello animale M. Chiaretti, J. Andreuccetti, A. I. Chiarettia, G.A.Carrub, D. Tuscano, Paolo Negro Chirurgia Generale e Day Surgery, Dipartimento Chirurgia Generale, “Paride Stefanini”, Università degli Studi di Roma “La Sapienza”. a Ospedale S. Andrea, II Facoltà di Medicina e Chirurgia, Università degli Studi di Roma b Ospedale Policlinico Umberto I, Università degli Studi di Roma La chirurgia dei difetti della parete addominale utilizza materiali protesici leggeri, resistenti, biocompatibili, economici, per ridurre il rischio di recidiva, migliorare il confort postoperatorio, abbreviare la degenza. La “Protesi Ideale” dovrebbe anche essere applicabile rapidamente, bioadesiva, e utilizzabile sia nella chirurgia open sia in laparoscopia. Dovrebbe poter prevenire il rischio di neuropatia dolorosa cronica, [5,6] e proteggere dalle teoriche ma possibili infezioni, non ancora conosciute e quindi non diagnosticabili, trasmissibili con i materiali biologici usati per confezionare le colle di fibrina [6]. Abbiamo studiato un nuovo materiale, il Buckypaper di nanotubi di carbonio (BP), nato per altri impieghi ma lavorabile con forbice, sterilizzabile in autoclave [1,3], superleggero, flessibile, bioadesivo e biocompatibile. Il BP risulta utile per il fissaggio di tutti i materiali protesici attualmente esistenti in commercio, compresi cateteri ed elettrodi, ai tessuti biologici viventi; è d’uso semplice, versatile, efficace, economico, affidabile e sicuro sul modello animale, permettendo di velocizzare la procedura chirurgica. Abbiamo eseguito la sperimentazione in vivo su ratti Sprague_Dawley e la sperimentazione di banco su conigli New Zeeland. Stiamo valutando l’ipotesi di utilizzare il BP in sostituzione dei mezzi di sintesi e collanti biologici attuali. [5, 6], proteggendo il paziente da teoriche ma possibili infezioni trasmissibili e neuralgia cronica legata ad eventuale “entrapment”. Il BP sembra essere un materiale protesico bioadesivo migliore di tutti quelli attualmente in commercio e pone una seria ipoteca sui sistemi di fissaggio protesico, che potrebbero cambiare radicalmente, qualora il BP confermasse la sua perfetta biocompatibilità . 1.Chiaretti, M.; Mazzanti, G.; Bosco, S.; Bellucci, S.; Cucina, A.; Le Foche, F; Carru, G A; Mastrangelo, S; Di Sotto, A ; Masciangelo, R; Chiaretti, A M; doi:10.1088/0953- 8984/20/47/474203. J. Phys.: Condened Matters 2008, 20, 47-57. 2.Chiaretti, M.; Cucina, A.; Bellucci, S.; Di Sotto A; Mazzanti G.; www.icact.com Abstract book of 20th International Congress on Anti-Cancer Treatment 2009, 438-439. 3.Bellucci S, Chiaretti M., Onorato P. Rossella F., Simone M. 2009, september 21-22 Micro-Raman study of effect of sterilization on carbon nanotubes for biomedical applications. Poster Session 2nd. National Nanomedicine Conference Padova. 4.Multi Walled Carbon Nanotube buckypaper: toxicology and biological effects in vitro and in vivo.; Bellucci, S.; Chiaretti, M..Cucina, A.; Carru, G A; Chiaretti, A I. Nanomedicine (2009) 4(5); 531-540 ISSN 1743-5889 5.Sunderland S.: Nerves and nerve jniury. Livingstone, Edinburg.1968. 6.Olmi S.Addis A: Experimental comparison of type of Tissucol dilution and composite mesh (Parietex) for laparoscopic repair of groin and abdominal hernia: observational study conducted in a university laboratory. Hernia. 11:211-215 (2007)
Low anterior resection versus abdominoperineal excision: A comparison of local recurrence after curative surgery for "very low" rectal cancer
No full textIn the controversy regarding whether sphinctersaving resection (SSR) or abdominoperineal resection (APER) is more appropriate for the treatment of very low rectal cancer, local recurrence rates seem to play a fundamental role in patient outcome. In order to operate an effective patient selection, very low rectal cancer is defined herein as being located within 4.5 to 7.5 cm from the anal verge. This retrospective report investigates the incidence of local recurrence after curative surgery for very low rectal carcinoma in 24 consecutive patients treated by the same surgical team over a 15-year period using the above surgical procedures. In the APER group, the local recurrence rate was 45.5%, occurring in 5 of 11 cases; and in the SSR group 46.1%, occurring in 6 of 13 cases, with no significant difference between the two groups. Recurrence was found within one year of surgical treatment in all except one case. Despite the strict follow-up program, it was only possible to perform reoperation in two recurrent cases, both previously submitted to SSR and diagnosed by means of transanal ultrasonography and macrobiopsy. The high incidence of local recurrence in this series is explained by the advanced stage of disease in the majority of cases. Thus, as the choice between APER and SSR does not seem to affect the incidence of local recurrence, which is related more to tumor size, site, stage, and grading, preservation of the sphincters and restoration of digestive continuity should be achieved whenever technically possible. © 1992 Springer-Verlag
Ulcerated ectopic gastric mucosa of the rectum
No full textGastric ectopic tissue has been found in the tongue and mouth, in the esophagus, duodenum, small bowel, colon, and in Meckel's diverticula. Umbilical polyps, the bladder, appendix, gallbladder, and rectum, as well as pancreatic, intrathoracic, intra-abdominal, and spinal cysts, have all harbored gastric tissue. The first description of gastric heterotopia of the rectum was given in 1939. Other similar cases were found later. We report a young patient with rectal bleeding from an ulcerative lesion localized in ectopic gastric mucosa of the rectum
New fixing method for open and laparoscopic surgical prosthetic materials tested on animal models
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Introduction: the abdominal wall defects surgery needs of prosthetic light, resistant, biocompatible and economic materials, to reduce recurrence risks, shorten recovery length and improve the patients postoperative comfort. The Ideal prosthesis would be simply implantable, biocompatible and usable both in open and laparoscopic surgery. The material we tested is also bioadhesive. Methods&Materials: we studied a new material, the Buchypaper of Carbon Nanotubes (BP). About BP we observed that it can be tailored with scissors, it can be sterilized, it is superlight, flexible, bioadhesive and biocompatible. The BP can be linked to any kind of prosthetic material and employed to fix the prosthesis to biological alive tissues. We tested on Sprague Dawley rat model and bench tests on New Zeeland female rabbits. The measurement of the bioadhesivity was realized by peeling test at 90° with INSTRON 4502. Results: we compared BP Fmax=4.1 N versus Parietene Progrip® “self gripping” Fmax=0.01 N. Infinity GORE Fmax=0,3 N, were fixed to the biological support with fibrin glue Tissucol® Baxter. Test show the adhesion strength of new dry BP sample applied on biological support. As peel force is applied we measure the displacement of self-gripping BP from fascia and muscular layer. For the samples of BP tested on the smooth surface (BPs), BP tested on the rough surface. We compared these results with the peeling test of Parietene Progrip® “self gripping”. The bio-adhesiveness of the side coated with polyglactin is very low, showing maximum peel strength of only 0.001 N/mm, 100 times lower than that recorded for BPr sample. Conclusions: the tests showed a significant performance difference among the prosthetic samples. At the light of our experience we think that the BP can replace any kind of suture and biologic glues in the fixing prosthesis materials in the alive tissues, avoiding theoretically but possible infections and chronic pain due to nerve “entrapment”. The BP showed a bioadhesivity 100 times bigger than the best self gripping actually marketed prosthetic material. We believe that the modifiable BP bioadhesivity, if largely employed, can radically change the fixing surgical technique.URL LAVORO: https://link.springer.com/article/10.1007/s00464-012-2198-3#citeas
GRANT_NUMBER: ERDF DI9_20 2011-2013 URL: http://www.regione.abruzzo.it/xEuropa/docs/beneficiariPor/beneficiari23022016.pdf
GRANT_NUMBER: C26A10HCNR/2010, Project 349/2012 URL: http://www.uniroma1.it/sites/default/files/PROGETTI_UNIVERSITÃ _1.pd
D. Tuscano, S. Toccaceli , B. Battillocchi, L. D’Amore, M. Massucci, F. Francioni, P. Negro “Occlusione intestinale inusuale nella donna da diverticolo di Meckel”. Chirurgia Generale – General Surgery, XX:181, 1999.
No full textPrimary omental torsion (POT): a review of literature and case report
Full text linkAbstract Eitel first described omental torsion in 1899, since then, fewer than 250 cases have been reported. Although omental torsion is rarely diagnosed preoperatively, knowledge of this pathology is important to the surgeon because it mimics the common causes of acute surgical abdomen. For this reason, in the absence of diagnosed preexisting abdominal pathology, including cysts, tumors, foci of intra-abdominal inflammation, postsurgical wounds or scarring, and hernial sacs, omental torsion still can represent a surprise. Explorative laparotomy represents the diagnostic and definitive therapeutic procedure. Presently laparoscopy is the first choice procedure.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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