51 research outputs found
Application of GIS and Remote Sensing in Research
No full textThe author added the ppt in the attachment. Lectures on Application of GIS and Remote Sensing in Research are available on YouTube channel.
For Bangladeshi learners: https://www.youtube.com/playlist?list=PL1qZn0OvlNyUJ74bx9WLIRonhgAid2BlFE-mail: [email protected]; Website:https://researchsociety20.org/teacher-trainer/ ;
Research gate: https://www.researchgate.net/profile/Md-Miah-8
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Biophysical Characterization of Alpha-Synuclein Membrane Binding Modes Determined by Membrane Properties
No full textAlpha-Synuclein (aSyn) is an intrinsically disordered neuronal protein that forms an amphipathic helix when it peripherally binds to lipid membranes. This protein is associated with Parkinson’s Disease (PD) and despite decades of research, the physiological function of aSyn is still not entirely understood. The evidence strongly supports the interaction of aSyn with neuronal membranes to be integral to its function, motivating the careful study of its membrane-binding behavior. Thus, this thesis aims to understand this interaction in greater detail through understanding how the binding modes of the protein change with lipid composition and PD-associated mutants, and how other physiologically relevant properties such as protein concentration, osmotic stress, and calcium ions affect the membrane binding behavior. Overall, we demonstrate that even small changes in membrane properties can have downstream effects that could be physiologically relevant
Adrenergic Agonists Bind to Adrenergic-Receptor-Like Regions of the Mu Opioid Receptor, Enhancing Morphine and Methionine-Enkephalin Binding: A New Approach to “Biased Opioids”?
No full textfirst_pageDownload PDFsettingsOrder Article ReprintsOpen AccessArticleAdrenergic Agonists Bind to Adrenergic-Receptor-Like Regions of the Mu Opioid Receptor, Enhancing Morphine and Methionine-Enkephalin Binding: A New Approach to “Biased Opioids”?by Robert Root-Bernstein1,* [ORCID] , Miah Turke1, Udaya K. Tiruttani Subhramanyam2,3, Beth Churchill1 and Joerg Labahn2,31Department of Physiology, Michigan State University, 567 Wilson Road, Room 2201 Biomedical and Physical Sciences Building, East Lansing, MI 48824, USA2Centre for Structural Systems Biology (CSSB), Notkestraße 85, 22607 Hamburg, Germany3Forschungszentrum Juelich GmbH, ICS-6, 52425 Juelich, Germany*Author to whom correspondence should be addressed.Int. J. Mol. Sci. 2018, 19(1), 272; https://doi.org/10.3390/ijms19010272Submission received: 8 December 2017 / Revised: 10 January 2018 / Accepted: 13 January 2018 / Published: 17 January 2018(This article belongs to the Section Bioactives and Nutraceuticals)Downloadkeyboard_arrow_downBrowse FiguresVersions NotesAbstractExtensive evidence demonstrates functional interactions between the adrenergic and opioid systems in a diversity of tissues and organs. While some effects are due to receptor and second messenger cross-talk, recent research has revealed an extracellular, allosteric opioid binding site on adrenergic receptors that enhances adrenergic activity and its duration. The present research addresses whether opioid receptors may have an equivalent extracellular, allosteric adrenergic binding site that has similar enhancing effects on opioid binding. Comparison of adrenergic and opioid receptor sequences revealed that these receptors share very significant regions of similarity, particularly in some of the extracellular and transmembrane regions associated with adrenergic binding in the adrenergic receptors. Five of these shared regions from the mu opioid receptor (muOPR) were synthesized as peptides and tested for binding to adrenergic, opioid and control compounds using ultraviolet spectroscopy. Adrenergic compounds bound to several of these muOPR peptides with low micromolar affinity while acetylcholine, histamine and various adrenergic antagonists did not. Similar studies were then conducted with purified, intact muOPR with similar results. Combinations of epinephrine with methionine enkephalin or morphine increased the binding of both by about half a log unit. These results suggest that muOPR may be allosterically enhanced by adrenergic agonists
Glutathione and Glutathione-Like Sequences of Opioid and Aminergic Receptors Bind Ascorbic Acid, Adrenergic and Opioid Drugs Mediating Antioxidant Function: Relevance for Anesthesia and Abuse
No full textOpioids and their antagonists alter vitamin C metabolism. Morphine binds to glutathione (l-γ-glutamyl-l-cysteinyl-glycine), an intracellular ascorbic acid recycling molecule with a wide range of additional activities. The morphine metabolite morphinone reacts with glutathione to form a covalent adduct that is then excreted in urine. Morphine also binds to adrenergic and histaminergic receptors in their extracellular loop regions, enhancing aminergic agonist activity. The first and second extracellular loops of adrenergic and histaminergic receptors are, like glutathione, characterized by the presence of cysteines and/or methionines, and recycle ascorbic acid with similar efficiency. Conversely, adrenergic drugs bind to extracellular loops of opioid receptors, enhancing their activity. These observations suggest functional interactions among opioids and amines, their receptors, and glutathione. We therefore explored the relative binding affinities of ascorbic acid, dehydroascorbic acid, opioid and adrenergic compounds, as well as various control compounds, to glutathione and glutathione-like peptides derived from the extracellular loop regions of the human beta 2-adrenergic, dopamine D1, histamine H1, and mu opioid receptors, as well as controls. Some cysteine-containing peptides derived from these receptors do bind ascorbic acid and/or dehydroascorbic acid and the same peptides generally bind opioid compounds. Glutathione binds not only morphine but also naloxone, methadone, and methionine enkephalin. Some adrenergic drugs also bind to glutathione and glutathione-like receptor regions. These sets of interactions provide a novel basis for understanding some ways that adrenergic, opioid and antioxidant systems interact during anesthesia and drug abuse and may have utility for understanding drug interactions
Application of GIS and Remote Sensing in Research
No full textThe author added the ppt in the attachment. Lectures on Application of GIS and Remote Sensing in Research are available on YouTube channel.
For Bangladeshi learners: https://youtube.com/playlist?list=PL1qZn0OvlNyUwuRDcgV5IrkSzfRKlhpa7
Lecture topic
Introduction of GIS and Theoretical Concept
Concept of Geo-processing, Basic Geo-processing tools
Basic concept of Python for ArcGIS and Basic ArcPy Script
Fundamentals of Remote Sensing and Theoretical Concept
Image Processing and How to Create a study area Map
Image Processing and How to Create a study area Map
Iso Cluster Unsupervised Classification
Erosion and Accretion calculation
Model builder
Network Analysis
Hotspot Analysis
Climate data download: free data sources and how to download data by Python code
Understanding gridded data and spatial figures
Spatial data analysis with IDW technique
Spatial data analysis using NetCDF dataE-mail: [email protected]; Website:https://researchsociety20.org/teacher-trainer/ ;
Research gate: https://www.researchgate.net/profile/Md-Miah-8
Design of an experimental model for a semi-active vibration damping system on a jack-up platform
No full textJack-up platforms are off-shore structure which are more often placed in deeper water and harsher weather conditions. The consequence is that the natural frequency of the platform coincides with the wave frequency and starts to resonate in its natural frequency. The problem becomes more complicated, due to the fact that the natural frequency of the platform is not constant and varies in time due to structural properties, variable deck loading and environmental conditions. These vibrations are undesired and have to be damped. The aim of this thesis is to design an experimental model for a damping system on a jack up platform, which can optimally damp the motion of the primary structure when it is excited in the time varying natural frequency. This problem is tackled by comparing passive, semi-active and active Tuned Mass Damper (TMD) systems, regarding feasibility and robustness for installation on a jack-up platform. Hereafter the optimal tuning frequency and damping ratio are obtained by studying the work of Tsai and Lin, Connor and Den Hartog. These tuning laws are then combined with a Self-Tuning Regulator (STR), which makes it possible to continuously tune the semi-active damping system to its optimal parameters by estimating the unknown structural parameter using a Recursive Least Square Estimator. The designed experimental model is a two degree of freedom model and incorporates crucial characteristics such as mass distribution, damping ratio and natural frequency. The semi-active TMD system is able to adapt its stiffness and damping coefficient, such that is it always optimally tuned when the structural parameters of the experimental model changes. This thesis concludes that a semi-active TMD system is the most appropriate type of damping system for a jack-up platform, regarding feasibility and robustness. A semi-active TMD system in combination with optimal tuning laws and a STR is able to optimally damp the vibrations of a jack-up platform, when it is excited in time varying natural frequency. This model can be used to test and validate the performance of the damping system and controller.Control EngineeringDelft Center for Systems and ControlMechanical, Maritime and Materials Engineerin
Acquirer reputation in mergers and acquisitions
No full textReputation is a firm’s key intangible assets for shareholders’ value creation. Reputation building is a firm’s corporate strategy approach that is vital for the firm in order to sustain itself in this competitive global world. The influence of reputation on firm’s performance, decision making, employee retainment, cost reduction, and partner selection have been studied and documented by academics. Despite this, there have been insufficient studies on reputation and mergers and acquisitions (M&A) activity. M&As are an important corporate strategy that firms use to survive and expand their global market. In the UK, both the number and value of domestic and cross-border M&As has increased significantly over the years. Drawing from the emerging popularity of reputation and the increased amount of M&A activity by UK acquirers, this thesis investigates the relation between reputation and UK acquirer M&A activity.
This thesis focuses on three main issues: (1) the impact of reputation on acquirer cross-border M&A returns; (2) the relation between reputation and UK acquirer domestic and cross-border deal completion time; and (3) the relation between UK acquirer reputation and target’s ownership nature.
Firstly, event-time and calendar-time approaches are used to examine UK acquirer cross-border M&A returns. The result reveals a significant relation between reputation and acquirer M&A returns. The author finds high reputation acquirers earned significant cross-border event-time and calendar-time returns. Secondly, this study finds a significant positive relation between acquirer reputation and domestic and cross-border deal completion time. This result implies that a high reputation acquirer takes more time to complete a deal. Lastly, the author finds a high reputation acquirer is more likely to choose a public target over a private target in domestic and cross-border M&As. However, the author finds a mixed result for subsidiaries: a high reputation acquirer is more likely to choose a subsidiary for a cross-border M&A, and less likely to for a domestic M&A
Adrenergic Agonists Bind to Adrenergic-Receptor-Like Regions of the Mu Opioid Receptor, Enhancing Morphine and Methionine-Enkephalin Binding: A New Approach to "Biased Opioids"?
No full textExtensive evidence demonstrates functional interactions between the adrenergic and opioid systems in a diversity of tissues and organs. While some effects are due to receptor and second messenger cross-talk, recent research has revealed an extracellular, allosteric opioid binding site on adrenergic receptors that enhances adrenergic activity and its duration. The present research addresses whether opioid receptors may have an equivalent extracellular, allosteric adrenergic binding site that has similar enhancing effects on opioid binding. Comparison of adrenergic and opioid receptor sequences revealed that these receptors share very significant regions of similarity, particularly in some of the extracellular and transmembrane regions associated with adrenergic binding in the adrenergic receptors. Five of these shared regions from the mu opioid receptor (muOPR) were synthesized as peptides and tested for binding to adrenergic, opioid and control compounds using ultraviolet spectroscopy. Adrenergic compounds bound to several of these muOPR peptides with low micromolar affinity while acetylcholine, histamine and various adrenergic antagonists did not. Similar studies were then conducted with purified, intact muOPR with similar results. Combinations of epinephrine with methionine enkephalin or morphine increased the binding of both by about half a log unit. These results suggest that muOPR may be allosterically enhanced by adrenergic agonists. View Full-Text Keywords: biased opioids; morphine; methionine-enkephalin; epinephrine; norepinephrine; enhancement; synergy; allosteric; mu opioid receptor; receptor dimers; dimerizatio
<i>Clostridia</i> and Enteroviruses as Synergistic Triggers of Type 1 Diabetes Mellitus
No full textWhat triggers type 1 diabetes mellitus (T1DM)? One common assumption is that triggers are individual microbes that mimic autoantibody targets such as insulin (INS). However, most microbes highly associated with T1DM pathogenesis, such as coxsackieviruses (COX), lack INS mimicry and have failed to induce T1DM in animal models. Using proteomic similarity search techniques, we found that COX actually mimicked the INS receptor (INSR). Clostridia were the best mimics of INS. Clostridia antibodies cross-reacted with INS in ELISA experiments, confirming mimicry. COX antibodies cross-reacted with INSR. Clostridia antibodies further bound to COX antibodies as idiotype–anti-idiotype pairs conserving INS–INSR complementarity. Ultraviolet spectrometry studies demonstrated that INS-like Clostridia peptides bound to INSR-like COX peptides. These complementary peptides were also recognized as antigens by T cell receptor sequences derived from T1DM patients. Finally, most sera from T1DM patients bound strongly to inactivated Clostridium sporogenes, while most sera from healthy individuals did not; T1DM sera also exhibited evidence of anti-idiotype antibodies against idiotypic INS, glutamic acid decarboxylase, and protein tyrosine phosphatase non-receptor (islet antigen-2) antibodies. These results suggest that T1DM is triggered by combined enterovirus-Clostridium (and possibly combined Epstein–Barr-virus-Streptococcal) infections, and the probable rate of such co-infections approximates the rate of new T1DM diagnoses
Muslim discourses on integration and schooling
No full textSince 2001 Muslim communities in Britain have largely been governed through the educational policy framing of integration and segregation. This Manichean bio-construct sees mono-cultural ethnic schools as problematic spaces, whilst integrated schools as the liberal ideal. By drawing upon the subaltern studies approach, this study provides a space for Muslim pupils and parents to articulate their own discourses on integrated and segregated schools in Britain. In doing so, it allows Muslim communities a position of power, by giving them agency to construct their own narratives on the policy debate on integration and schooling.
This thesis attempts to make sense of Muslim discourses through a theoretic interpretation drawn from Muslim intellectual history. By using Ibn Khaldun’s (d. 1406) sociological theory of ‘asabiyya this study provides a broader theoretical context to the Muslim voice. The empirical and the theoretical perspectives contained in this study attempts to make significant contributions to the study of race, religion and Muslim studies in Britain.
Public policy discourses has often seen the concept of integration as a linear cultural process, with minority groups gradually adopting the social mores of the host society. Evidence presented in this study sees integration as an analytical process and not as a fixed cultural template. It shows how the concept of integration can often be used, by political actors, as a tool for anti-Muslim racism.
The discourses of Muslim parents and pupils have much in common with each other, especially when rejecting the idea of self-segregation, or highlighting the importance of ‘asabiyya based on religion, but they have little in common with the public policy framing of Muslim communities.
Sociological studies have often demonstrated the disjuncture between public policy and lived experience. This study confirms this observation by elucidating the disconnect between political discourse of integration and lived cultural experience of Muslim communities. The discourses of Muslim communities in this study suggest a complex, paradoxical, intersectional reading of integration, which is fundamentally rooted within social constructionism. Most importantly it dismisses the integration and segregation binary, as seen within the educational framing of Muslims, whilst recognising the importance of Muslim group solidarity, or ‘asabiyya in Muslim discourse
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