111,811 research outputs found
Retrospective study of 152 feline cytological bone marrow examinations: preliminary classification and ranges
No full textObjectives Cytological assessment of the bone marrow is an essential tool for understanding and investigating haematological abnormalities. Sometimes it represents the only way to reach a definitive diagnosis. The purpose of this study was to provide a general overview regarding the prevalence of feline bone marrow disorders encountered in a private European laboratory setting, to classify them and to assess the differential cell counts related to such disorders. Methods In total, 152 bone marrow samples were classified using cytological and numerical criteria. The bone marrow cytological examinations were performed after the identification of haematological alterations, such as cytopenias, increased number of cells or suspicion of malignant blood disorders. Results Of the 152 bone marrow samples evaluated, 71 (46.7%) were classified as hyperplastic, primarily granulocytic and erythroid hyperplasia (50.7% and 45.1%, respectively, of the total hyperplasia); 23 (15.1%) showed dysmyelopoiesis, mainly in the form of myelodysplastic syndrome (39.1% of the total dysmyelopoiesis); 21 (13.8%) had no cytological abnormalities; 17 (11.2%) were malignant blood disorders; 15 (9.9%) had hypoplastic conditions; and two (1.3%) were miscellaneous diseases. Metastatic disease was detected in only two cases (1.3%). Differential cell counts and myeloid-to-erythroid (M:E) ratios were reported for normal, erythroid hypoplastic, erythroid and granulocytic hyperplastic and dysplastic conditions. Conclusions and relevance This study provides a general overview of the prevalence and incidence of feline bone marrow disorders together with ranges for differential nucleated cell counts and M:E ratios for the various conditions reported
ABNORMAL FINDINGS IN HAEMOGRAMS OF DACHSHUND PUPPIES: PRESUMPTIVE (IMMUNODEFICIENCY) FAMILIAL DISEASE
No full textIn a litter of seven Dachshund puppies, one subject was stillborn and six presented with diffuse skin
infections characterized by dermatitis, abscessation, pustules, crusts and ulcers. Two of the puppies were
referred for further evaluation. One male puppy was referred at four months of age and a sister litter mate was
referred two months later. A complete blood count, biochemical and histological examination were performed
on these puppies to identify the pathologic process. Clinical, biochemical, haematological and histological
evaluation of subjects. This report characterizes quantitative and qualitative haematological abnormalities in
two puppies that resulted in a diagnosis of dysmyelopoiesis. The existence of a familial immunodeficiency
syndrome was speculated. This is the first report of such a syndrome in Dachshund puppies
Canine bone marrow cytological examination: a retrospective study of 295 cases
No full textnon dsponibil
Canine bone marrow cytological examination, classification and reference values: A retrospective study of 295 cases
No full textCytologic assessment of bone marrow with knowledge of the hemogram represents an effective method to investigate hemic tissue and its function. To determine the spectrum and prevalence of canine bone marrow disorders over a 2 year period in a diagnostic laboratory setting achieved through a standard approach to cytologic bone marrow assessment. A retrospective study of bone marrow fine needle aspirates sample preparations, blood smears, hemogram data and case records. Of the 295 bone marrow samples evaluated, 90 (30.5%) were nondiagnostic samples. Of the remaining samples, 25.1% were classified as hyperplasia of which most were granulocytic hyperplasia (58.1% of the total hyperplasia), 19.3% had no cytological abnormalities, 12.9% had malignant hemopathy and 7.8% had hypo-aplastic conditions. Only a small proportion of cases involved dysplasia (1.7%) and metastatic disease was detected in only one case (0.3%). Reference values of nucleated cells and the M/E ratio were calculated for normal and erythroid and granulocytic hyperplastic bone marrow. This study provides the spectrum and the prevalence of canine bone marrow disorders as well as a differential bone marrow cell counting and determination of reference intervals for diseases
NORMAL CYTOLOGICAL BONE MARROW EXAMS ASSOCIATED TO ALTERED HEMOGRAMS IN CATS: A RETROSPECTIVE STUDY
No full textBackground: bone marrow and blood smear cytological analysis together with a complete hemogram represent the only method for examining the hematopoietic tissue and function. Sometimes in clinical practice, pathological hemograms are associated with cytological normal bone marrow exams.
Objective: the aim of this retrospective study was to evaluate a series of feline cytological bone marrow samples, together with hematological and clinicopathological data. This, to judge if the normality of these cytological exams is reliable or if it indicates an intrinsic failure.
Methods: two-hundred-fourteen bone marrow samples and blood smears were examined using morphological and numerical criteria together with complete hemograms. Bone marrow cytological examinations were performed after the identification of hematological or clinical alterations such as anemia, leukocytosis, fever of unknown origin, and staging of neoplasia (i.e., lymphoma).
Results: among the 214 bone marrow samples evaluated, 41 (19%) were classified as normal. However, only 4 of those cases (10%) exhibited normal hemograms. The most common hematological anomalies, often seen in combination, were anemia (56%), thrombocytopenia (17%) and leucopenia (10%). Furthermore, anemia associated with other abnormal hematological findings (51 %) and lymphoma (15%) were the most frequent indication for bone marrow examination.
Conclusion: this retrospective study suggests that bone marrow cytological exams, despite appearing normal in terms of morphological or numerical parameters, can still be associated with abnormal hemograms. As a result, they should not be automatically considered as clinically normal. Instead, they should prompt additional research and, occasionally, a second cytological bone marrow examination in the following days
A case report of T-cell lymphoma in a horse
No full textLymphoma is a solid neoplasm of the lymphoid organs (lymph nodes, spleen, etc.). It
is the most common neoplasm of the horse’s haematopoietic system, although not
common in absolute terms, and has a prevalence ranging from 1% to 3% of all
tumours. It is subtyped into four anatomical forms: multicentric, alimentary, mediastinic
and cutaneous. Multicentric lymphoma is the most common form and usually
involves the lymph nodes and other lymphoid organs, but it can induce metastases to
the liver, lungs and kidneys. The clinical signs of lymphoma are associated with the
degree of organ involvement and can include aspecific symptoms such as weight loss,
depression, lymphadenopathy, intermittent fever, respiratory disturbances and recurrent
colic. The diagnosis of equine lymphoma requires a complete clinical examination
including rectal palpation, complete blood count (CBC), extended biochemical
profile, bone marrow aspirate sampling, serum electrophoresis, liver and spleen
echography and finally, fine-needle aspiration (FNA) or surgical biopsy of enlarged
lymph nodes or any other eventual masses occurring. Lymphoma can be classified in
terms of degree of malignancy as ‘low’ (prevalence of small lymphocytes similar to
those appearing in the peripheral blood) or ‘high’ (composed of large lymphoblasts,
when the tumour is more aggressive). The most significant classification is based on
the lymphoid cell type from which the neoplasm has originated (T- or B-cell type)
(Carlson, 1996; Kelley and Mahaffey, 1998; Savage, 1998; McClure, 2000)
author-bios-SRD-19-0063.R1 – Supplemental material for The Network Structure of Police Misconduct
No full textSupplemental material, author-bios-SRD-19-0063.R1 for The Network Structure of Police Misconduct by George Wood, Daria Roithmayr and Andrew V. Papachristos in Socius</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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