1,721,057 research outputs found
The role of human autoantibodies against gamma-interferon.
No full textNatural antibodies to γ-interferon (IFN-γ) were detected in the serum of viral infected patients and also in the serum of healthy subjects at a lower titre. The increased titres of antibodies to IFN-γ in sera from viral infected patients, and their decrease with clinical resolution, indicates that these antibodies are related to the viral infection and probably reflect IFN-γ production as a result of antigenic stimulation in vivo. These antibodies were affinity-purified and studied for their capability to interfere with the multiple activities of IFN-γ in vitro. Data obtained show that human anti-IFN-γ antibodies interfere with the immunomodulating activity but not with the antiviral and antiproliferative activity of lymphokine. Autoantibodies to IFN-7 may have a role in the immunoregulatory process serving to limit the intensity and or duration of the immune response. Being able to interfere with the immunomodulating activities of IFN-γ, these antibodies might open up new therapeutic possibilities for those diseases which carry evidence of activated cell-mediated immunity
Valutazione del rischio da stress lavoro-correlato in un’azienda pubblica: difficoltà e proposte operative
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Pefloxacin in the treatment of acute severe infections in hospitalized patients. Clinical and bacteriological evaluation.
No full textIncreased frequency of Ureplasma urelyticum and Mycoplasma genitalium detection in AIDS patients without urethral symptoms.
No full textIn-vitro activity of cefotetan and other cephalosporins on Klebsiella and resistance to inactivating bacterial enzymes
No full textThe effect of cefotetan on different clinical isolates of Klebsiella has been compared to that of other cephalosporins. The post-antibiotic effect and the effect of pulse-dosing of cefotetan were also tested by an original method whereby the antibiotic was removed with an ion-exchange resin. Finally, the resistance of cefotetan to inactivating enzymes of bacterial origin has been compared with that of other cephalosporins
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Natural antibodies to interferon-gamma in humans: inhibition of the biological activity of IFN-gamma by human anti-IFN-gamma antibodies.
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