175,262 research outputs found
Progression Independent of Relapse Activity in Multiple Sclerosis: Closer to Solving the Pathologic Puzzle
No full textPaket Tur Sözleşmesi
No full textTurizm bütün dünyada olduğu gibi ülkemizde de oldukça önemli bir iş sahasıdır. Yerli veya yabancı turistlerin tatillerini veya kısıtlı zamanlarını daha verimli ve profesyonel şekilde değerlendirme istekleri ülkemizde de belli kanuni düzenlemelerin yapılması ihtiyacını doğurmuştur. Paket tur sözleşmesi, 2003 yılında 4822 sayılı Tüketicinin Korunması Hakkında Kanunda Değişiklik Yapılmasına Dair Kanun’la 4077 sayılı Tüketicinin Korunması Hakkında Kanun’a eklenen madde 6/C hükmü ile ilk defa yasal düzenlemede kendisine yer bulmuştur. Daha sonrasında 6502 sayılı yeni Tüketicinin Korunması Hakkında Kanun’un 51’inci maddesinde paket tur sözleşmesine yer verilmiştir. 14.01.2015 tarihli ve 29236 sayılı Resmi Gazete’de yayınlanan Paket Tur Sözleşmeleri Yönetmeliği ile de kanunun maddelerinin nasıl uygulanacağı belirlenmiştir. Bu çalışmada paket tur sözleşmesinin hukuki nitelendirilmesi, paket tur sözleşmesinin tarafları, paket tur sözleşmesinin unsurları, paket tur sözleşmesinde tarafların hak ve borçları, sözleşmenin hiç veya gereği gibi ifa edilmemesi ve bundan doğan sorumluluk, sorumluluktan kurtulma, sözleşmenin devri, sözleşmenin feshi ve sözleşmenin arabuluculuk kapsamına alınması hususları incelenecektir
Disorganized vestibular hair bundles in <i>Tur/Tur</i> mutant.
No full text(A-F) Phalloidin staining showing stereocilia in maculae in the utricle and saccule at P14. Hair bundles of Tur/Tur mice are irregular with no pattern of organization. Arrows in F point to elongation of stereocilia in the mutant when compared to that in normal mice (arrows in E). Panel E,F are higher magnification of boxed area in C,D. (G,H) Anti-myosin VI immunostaining on utricle sections. Scale bars: E,F, 13 μm and all other panels, 20 μm.</p
Progressive degeneration of hair bundles in <i>Tur/Tur</i> cochleae.
No full text(A,B) Immunofluorescence of anti-myosin VI on cochlear sections of wild-type (A) and Tur/Tur mutant at P0 (from middle turn). Arrow points to smaller tunnel of Corti in the mutant. (C-D) Phalloidin staining of whole-mount cochlear sensory epithelium (middle turn) from P0 (C,D), P14 (E,F) and P21 (G,H) with phalloidin (red). Myo6Tur/Tur cochleae show irregular shapes of hair bundles compared to wild-type cochleae throughout all regions of the cochlea. Asterisks in H point to degeneration or elongation of stereocilial bundles in the mutant at P21. IHC, inner hair cell; OHC, outer hair cell. Scale bar: 25 μm.</p
Degeneration of vestibular hair cells in <i>Tur/Tur</i> mutant.
No full textH&E staining of inner ear tissue at 4 weeks. (A-H) Posterior (A,B) and anterior (C,D) crista ampullaris, utricular macula (E,F) and Organ of Corti (G,H) in wild-type (A,C,E,G) and Tur/Tur mutant (B,D,F,H). Significant reduction of hair cells in the vestibular sensory organs (arrows in B,D,F) and collapse of the organ of Corti (arrow, H) are evident in the inner ear of Tur/Tur mice. Panels G,H are images showing the organ of Corti in the basal turn. Abb.: hc, hair cell; ihc, inner hair cell; ohc, outer hair cell; sc, supporting cell; tc, tunnel of Corti. Scale bar: A-F, 50 μm and G,H, 25 μm.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Marketing tur\uedstico :
No full textTrabajo Fin de Grado-Universidad Pontificia de Salamanca, Facultad de Comunicaci\uf3n, 2020El presente trabajo de investigaci\uf3n sobre marketing tur\uedstico se inicia con una revisi\uf3n bibliogr\ue1fica sobre este \ue1mbito y en particular, su desarrollo en los \ufaltimos 10 a\uf1os. Para ello, se ha llevado a cabo el estudio de algunos de los t\ue9rminos principales y necesarios para comprender el objeto de estudio de esta investigaci\uf3n. Analizando la conceptualizaci\uf3n del t\ue9rmino marketing tur\uedstico, delimitando la definici\uf3n de turismo, y determinando qu\ue9 se entiende por lujo y c\uf3mo se clasifica en funci\uf3n del tip
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
Economics of Tur (Cajanus cajan) Cultivation in North Karnataka, India
No full textTur is the most important Kharif pulse crop of northern Karnataka. Over the years, the farming community is shifting to cultivation of cash crops due to higher profitability leading to decrease in acreage under pulse crops in general and Tur in particular. The current study was carried out in Vijayapur and Bagalakote districts of north Karnataka to analyze the profitability in Tur cultivation and to document various constraints faced by the Tur growers in the study area. The data pertained to the agricultural year 2014-15. The yield per ha of Tur crop in was 15.08 quintals. The average price received by the sample farmers per quintal of Tur was Rs 5825.50. The total cost of cultivation was Rs 60260.37. The net returns per hectare of Tur cultivation was found to be Rs 27588.17, leading to an undiscounted benefit to cost ratio (Profitability ratio) of 1.45. The sample respondents ranked non-availability of labour as the greatest constraint in manual harvesting and mechanical threshing of Tur with a Garrett score of 70.73. The problems ranked as second, third and fourth place were high cost of labour, delay in harvesting and loss of crop due to unexpected pre-monsoon rains, respectively. Efforts should be made to bring more area under Tur crop in the study area. In spite of more yield and higher price of output, the net returns for Tur growers is less due to their higher investment in labour for carrying out various farm operations. To address this problem, mechanization of various operations such as ploughing, harrowing, sowing, harvesting and threshing should be done
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