1,721,134 research outputs found
Cytogenetic findings on shoe workers exposed long-term to benzene.
No full textCytogenetic analysis of peripheral blood lymphocytes was performed to detect cytogenetical alterations in 58 shoe workers (57 male and 1 female) who had been exposed to particular mutagenic or carcinogenic agents and in 20 subjects selected from the general population as a control group. Frequencies of damaged cells, including gaps, breaks, and rearrangements (acentric fragment, deletion, translocations) were scored for both groups. The incidence of chromosomal aberrations (particularly chromatid gaps and breaks) in the study group was significantly higher than in the control group. No effects of smoking were observed and breaks alone were found to be influenced by alcohol consumption. No significant correlation was detected between the working period in the group exposed to benzene and frequency of chromosomal aberrations. Benzene content was determined to be between 0 and 28.5% in eight kinds of glues studied by fractional distillation. Hexane content ranged between 0 and 68.35% using the same method. This study indicated that the content of benzene and hexane in the glues are above normal limits
Long non-coding rna hulc overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Cytogenetic investigations in shoe workers
No full textÇalışmamızda biri kadın, diğerleri erkek olan toplam 58 ayakkabı işçisi ve rasgele olarak seçilmiş biç bir mutajen ve kanserojen ajana maruz kalmamış 20 kişilik kontrol grubu üzerinde periferik kan lenfositleriyle, sitogenetik analiz yöntemi kullanılmıştır. Her iki grupta da, gap, kırık, asentrik fragman, rearrangement ve poliploididen oluşan hücresel hasarın sıklığı araştırılmıştır. Kromozomal hasar (Özellikle kromatid gap ve kırıkları) kontrol grubuna oranla, etkilenen grupta anlamlı bir şekilde yüksek bulunmuştur. Ayakkabı işçileri ve kontrol grubunu oluşturan bireylerin sigara kullanımları ve alkol alışkanlıkları hem kendi içlerinde hem de diğer grupla karşılaştırılmış, her iki durumda da karşılaşılmış her iki kriterler arasında bir ilişki bulunamamıştır. Ayrıca, çalışmaları sırasında benzenden etkilenme süresi ile kromozomal hasarın sıklığı arasında da anlamlı bir ilişki bulunamamıştır.In the present study, the method of cytogenetic analysis of peripheral blood lymphocytes was used to investigate 58 (57 men and 1 female) shoe workers exposed to benzene, and 20 individuals selected from general population not exposed to particular mutagenic or carcinogenic agents (control group). Frequecies of damaged cells, including gap, break, acentric fragment and rearrangement were scored in both groups. The incidence of chromosomal aberrations (particularly chromatid gaps and breaks) in the exposed group were significantly increased when compared with the control group. Shoe workers and the individuals of control group were compared according to their smoking and dirinking habits both by themselves and eachother. As a result of those comparisons no correlation was found in the incidence of.chromosomal aberration in both situations. In the same way, there wasn't found any significantly relation between the working period in the group exposed to benzene frequency of chromosomal aberration.Bursa Ayakkabıcılar Derneğ
The Investigation of genetic predisposition in patients with colorectal cancer and their relatives
No full textFrajil bölgeler kromozomlar üzerinde boya almayan özel gap ve kırık noktalandır ve onlar çeşitli kültür koşullan ile oluşturulabilirler. Çeşitli çalışmalar frajil bölge ekspresyonunu arttıran ve birçok klastojenik ajan olduğunu göstermiştir. Biz de çalışmamızda periferik kan lenfositlerinde gözlediğimiz prometafaz kromozomlarda common frajil bölgelerin ekspresyonunu afidikolin, bromodeoksiuridin ve kafein ile indükledik. Kromozomal aberasyonlar ve frajil bölge ekspresyonlan, 32 kolon kanserli hasta, 30 asemptomatik kolon akraba, 36 rektum kanserli hasta, 30 rektum akraba ve 30 da yaşlan hasta ve akraba grupları ile uyumlu, ailesinde kanser hikayesi bulunmayan sağlıklı kontrol bireylerinden oluşan toplam 158 vakada değerlendirildi. Hem hasarlı hücre oram (P0.05). Biz iki grubumuzda da apbidicolin tip common frajil bölgeler belirledik. Kolon kanserli hastalar ve yakınlarında belirlediğimiz frajil bölgeler lp36, lp31, lp21, lq21, lq25, lq44, 2p24, 2pl6, 2q21, 2q33, 2q37, 3p21, 3pl4, 15ql5, 5q21, 5q31, 13ql3 ve 14q24 şeklinde sıralanmaktadır. Bunlarm içinde lp21, lq21, lq25, lq44, 2p24, 2pl6, 2q33, 2q37, 3pl4, 5q21, 5q31 ve 14q24 frajil bölge oranları, kontrol grubu ile karşılaştırıldığında istatistiki olarak anlamlı bulundu (P0.05). We determined aphidicolin type common fragile sites in our both groups. These sites in patients with colon cancer and relatives were following : lp36, lp31, lp21, lq21, lq25, lq44, 2p24, 2pl6, 2q21, 2q33, 2q37, 3p21, 3pl4, 5ql5, 5q21, 5q31, 13ql3 and 14q24, In this fragile sites, lp21, lq21, lq25, lq44, 2p24, 2pl6, 2q33, 2q37, 3pl4, 5q21, 5q31 and 14q24sites were statistically significant when compared with control group (P<0.05-P<0.0001). Moreover expression of 2q33, 3pl4 and 5q21 sites were observed highest significant in all of fragile sites. Fragile sites in rectum cancered patients and their relatives were following: lp36,. Ip31, lp21, lq21, lq25, lq44, 2p24, 2q21, 2q33, 2q37, 3pl4, 5q21, 5q31, 13ql3, 14q24, 16q23 and 18q21. When compared with control group fragile sites of lp21, lq25, lq44, 2q33, 5q21, 5q31 and 14q24 were statistically significant (P<0.05-P<0.0005). Highest statistically significancy was observed in 2q33 in this group. Our results indicate that there is a relative increase in chromosomal aberrations and fragile sites expressions in patients with colorectal cancer and their relatives. These data also suggest that common fragile sites may really be preferential points of breakage and that then- expression might be primary Contibutors to chromosomal damages of the somatic genome. So this type studies may be helpful to early detection of cancer, clarifiy the biological mechanism of cancer development, progression and in the protection from cancer
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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