1,721,099 research outputs found
Le emozioni della notte
No full textFin dall’antichita' al sonno e ancor piu' ai sogni sono stati attribuiti significati diversi e complessi, tanto piu' affascinanti quanto piu' misteriosi. Oggi nessuno puo' affermare convintamente e convincentemente di conoscere le ragioni della bizzarria ed implausibilita' dei sogni. Cio' che invece puo' essere sostenuto e' che nel sonno l’attivita' mentale prosegue instancabilmente, generando pensieri e immagini a forte contenuto emozionale, spesso ancor piu' che nella veglia cosciente. Sappiamo inoltre che nel sonno gli eventi emozionali recenti hanno buon gioco a collegarsi con quanto si trova depositato in memoria e a scatenare quei potenti output emozionali che talvolta caratterizzano il sonno. Tutto questo avviene perche', come ha scoperto la piu' avanzata ricerca psicofisiologica, le sedi neurali che sostengono la memoria e le emozioni sono spesso le stesse
Spatial impairment and memory in genetic disorders: Insights from mouse models
No full textResearch across the cognitive and brain sciences has begun to elucidate some of the processes that guide navigation and spatial memory. Boundary geometry and featural landmarks are two distinct classes of environmental cues that have dissociable neural correlates in spatial representation and follow different patterns of learning. Consequently, spatial navigation depends both on the type of cue available and on the type of learning provided. We investigated this interaction between spatial representation and memory by administering two different tasks (working memory, reference memory) using two different environmental cues (rectangular geometry, striped landmark) in mouse models of human genetic disorders: Prader-Willi syndrome (PWScr
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Polarization and depolarization currents in carbon-black loaded polyolefins
No full textIn this paper the first results concerning an experimental investigation of the conduction mechanism in heat shrinkable carbon black-loaded polyolefins are reported by considering the dependence of charging and discharging currents on the adopted electrode material and specimen dimensions. Data concerning applied electrical stresses comparable with those encountered in service are discussed by considering models proposed in the literatur
Partial discharge testing on resin insulated voltage transformers
No full textThe lifetime of resin insulated voltage transformers
(RIVT) can be considerably shortened due to
partial discharge activity taking place inside the insulation
close to the active parts of the component. In that region
the presence of voids, due to manufacturing processes, and
the enhanced electric field stress lead to an intense partial
discharge activity which determines accelerated degradation
processes and eventually the ultimate failure of the
device. Partial discharge measurements together with an
estimation of the electric field distribution in RIVT seem
to be indispensable in order to fully understand transformer
performances. In this paper, a study of the electric
field distribution inside the RIVT, together with results of
partial discharge tests are presented. The influence of the
various test arrangements and methods on the experimental
results are investigated
NAA60 (HAT4): the newly discovered bi-functional Golgi member of the acetyltransferase family
No full textChromatin structural organization, gene expression and proteostasis are intricately regulated in a wide range of biological processes, both physiological and pathological. Protein acetylation, a major post-translational modification, is tightly involved in interconnected biological networks, modulating the activation of gene transcription and protein action in cells. A very large number of studies describe the pivotal role of the so-called acetylome (accounting for more than 80% of the human proteome) in orchestrating different pathways in response to stimuli and triggering severe diseases, including cancer. NAA60/NatF (N-terminal acetyltransferase F), also named HAT4 (histone acetyltransferase type B protein 4), is a newly discovered acetyltransferase in humans modifying N-termini of transmembrane proteins starting with M–K/M-A/M-V/M-M residues and is also thought to modify lysine residues of histone H4. Because of its enzymatic features and unusual cell localization on the Golgi membrane, NAA60 is an intriguing acetyltransferase that warrants biochemical and clinical investigation. Although it is still poorly studied, this review summarizes current findings concerning the structural hallmarks and biological role of this novel targetable epigenetic enzyme
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