1,721,396 research outputs found
Individual planning starts at school. Tools and practices promoting autonomy and supporting transition to work for adolescents with autism spectrum disorder
Full text linkThere is an increasing need for effective services and strategies to favor the transition from school to post-school/working experience for individuals with disabilities and specifically with autism spectrum disorder (ASD). Post-school options are still limited, and most adults with ASD struggle in finding adequate and stable job opportunities. This work analyzes the increasing number of laws issued in Italy in the last decades in order to improve social and working inclusion. The central role of the individual educational planning (IEP) as part of the broader individual project is discussed. Also the potential of pathways for transversal skills and orientation for future employment outcomes is taken into consideration. Good practices promoting autonomy and supporting transition to work starting from school years are reviewed. The international literature shows different models and tools, which could be applied to the Italian school. The COMPASS consultancy model could favor the achievement of individualized transition IEP goals. Peer mediated intervention could improve social skills, a core weakness in ASD, though a central element for success in the workplace. Another key element is the parental involvement in the construction of the future of their children with ASD
Microbial metabolites as predictive biomarkers: A paradigm shift for cardiovascular risk stratification
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Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study
No full textThe improved cardiac function in patients with congestive heart failure treated with coenzyme Q10 supports the hypothesis that this condition is characterized by mitochondrial dysfunction and energy starvation, so that it may be ameliorated by coenzyme Q10 supplementation. However, the main clinical problems in patients with congestive heart failure are the frequent need of hospitalization and the high incidence of life-threatening arrhythmias, pulmonary edema, and other serious complications. Thus, we studied the influence of coenzyme Q10 long-term treatment on these events in patients with chronic congestive heart failure (New York Heart Association functional class III and IV) receiving conventional treatment for heart failure. They were randomly assigned to receive either placebo (n = 322, mean age 67 years, range 30-88 years) or coenzyme Q10 (n = 319, mean age 67 years, range 26-89 years) at the dosage of 2 mg/kg per day in a 1-year double-blind trial. The number of patients who required hospitalization for worsening heart failure was smaller in the coenzyme Q10 treated group (n = 73) than in the control group (n = 118, P < 0.001). Similarly, the episodes of pulmonary edema or cardiac asthma were reduced in the control group (20 versus 51 and 97 versus 198, respectively; both P < 0.001) as compared to the placebo group. Our results demonstrate that the addition of coenzyme Q10 to conventional therapy significantly reduces hospitalization for worsening of heart failure and the incidence of serious complications in patients with chronic congestive heart failure. © 1993 Springer-Verlag
Aspirin, NOACs, warfarin: which is the best choice to tackle cognitive decline in elderly patients? Insights from the GIRAF and ASCEND-Dementia trials presented at the AHA 2021
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The role of the transcription factor nuclear factor kappa B in the regulation of cardiac hypertrophy
No full textCardiac hypertrophy is a maladaptive response to an injury, characterized by an increase in cell size, expression of fetal genes, fibrosis and apoptosis. Several signalling transduction pathways have been identified so far that are involved in this response and all of them converge on transcription factors that are the main regulator of the expression of hypertrophic genes. Among these, nuclear factor kappa B (NF-κB) is a key transcription factor regulating the expression of several genes involved in human inflammation and disease. Several reports have demonstrated the involvement of NF-κB in the regulation of cardiac hypertrophy, and different inhibitors of NF-κB activity have been described so far that are able to block NF-κB at different levels of its signalling transduction pathway. NF-κB inhibition is an effective strategy to reduce multiple aspects of cardiac hypertrophy such as cardiomyocyte size, fibrosis, inflammatory cytokines expression and apoptosis. This article focuses on recently described mechanisms of inhibition of NF-κB activity and their application to animal models of cardiac hypertrophy. All these reports add to the knowledge of NF-κB signalling and could be helpful for future studies that will be focused on the research of specific and non-toxic inhibitors of NF-κB activity to regulate cardiac hypertrophy and its evolution towards heart failure. © 2010 Adis Data Information BV. All rights reserved
Transient enhancement of sympathetic nervous system activity by long-term restriction of sodium intake.
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