118 research outputs found
Neuroendocrine neoplasms of the sinonasal region
No full textBell, Diana; Hanna, Ehab Y.; Weber, Randal S.; DeMonte, Franco; Triantafyllou, Asterios; Lewis, James S., Jr.; Cardesa, Antonio; Slootweg, Pieter J.; Stenman, Goran; Gnepp, Douglas R.; Devaney, Kenneth O.; Rodrigo, Juan P.; Rinaldo, Alessandra; Wenig, Bruce M.; Westra, William H.; Bishop, Justin A.; Hellquist, Henrik; Hunt, Jennifer L.; Kusafuka, Kimihide; Perez-Ordonez, Bayardo; Williams, Michelle D.; Takes, Robert P.; Ferlito, Alfi
Surgical margins in head and neck cancer: Intra- and postoperative considerations
No full textThomas Robbins, K., Triantafyllou, A., Suárez, C., López, F., Hunt, J.L., Strojan, P., Williams, M.D., Braakhuis, B.J.M., de Bree, R., Hinni, M.L., Kowalski, L.P., Rinaldo, A., Rodrigo, J.P., Vander Poorten, V., Nixon, I.J., Takes, R.P., Silver, C.E., Ferlito, A
Molecular events in relapsed oral squamous cell carcinoma: Recurrence vs secondary primary tumor
No full textSao Paulo Research Foundation (FAPESP) [2011/13315-4, 2013/09142-2]Gleber-Netto, F.O., Braakhuis, B.J.M., Triantafyllou, A., Takes, R.P., Kelner, N., Rodrigo, J.P., Strojan, P., Poorten, V.V., Rapidis, A.D., Rinaldo, A., Brakenhoff, R.H., Ferlito, A., Kowalski, L.P
Nasal juvenile angiofibroma: Current perspectives with emphasis on management
No full textLópez, F., Triantafyllou, A., Snyderman, C.H., Hunt, J.L., Suárez, C., Lund, V.J., Strojan, P., Saba, N.F., Nixon, I.J., Devaney, K.O., Alobid, I., Bernal–Sprekelsen, M., Hanna, E.Y., Rinaldo, A., Ferlito, A
Immunohistochemical characterization of capsular cells in neuromuscular spindles of the neck
No full text
Comparative immunohistochemical and molecular investigations of metabolic and stromal events in HPV positive and HPV negative oropharyngeal squamous cell carcinoma
No full textBackground: It has been shown that HPV positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) are characterised by extensive nodal disease, but are associated with significantly better prognosis than HPV negative (HPV-) OPSCC. It has also been proposed that glycosaminoglycans (GAGs) and myofibroblasts are components of the desmoplastic stroma that characterizes many advanced carcinomas. They are considered to play an important role in the pathogenesis of head and neck squamous cell carcinomas (HNSCC) and their presence is of high prognostic value. A 'three compartment tumour metabolism' model has been proposed in head and neck cancer comprising a proliferative, monocarboxylate transporter1 (MCT1)-expressing carcinoma cell population at the tumour advancing front (front) with both a deeper population of monocarboxylate transporter 4 (MCT4)+ cancer cells and (MCT4)+ cancer associated fibroblasts (CAFs) providing a source of metabolic fuels via a lactate shuttle. This thesis investigates the presence and distribution of GAGs and myofibroblasts in HPV+ and HPV- OPSCC, and their correlation with clinicopathological features. We also investigate the metabolic activities of OPSCC in relation to HPV status. ... (continues
Pitfalls and procedures in the histopathological diagnosis of oral and oropharyngeal squamous cell carcinoma and a review of the role of pathology in prognosis.
No full textHistopathological assessment of formalin-fixed biopsy tissue and surgical resection specimens remains the cornerstone of cancer diagnosis and pathological staging in routine clinical practice. In recent years, standard protocols for reporting head and neck cancer have been widely used and these have improved the general level of the pathological assessment. In this article, we look beyond the standard protocols and deal with potential difficulties and pitfalls in the assessment of incisional biopsy specimens, surgical resection specimens and neck dissections. We draw attention to possible shortcomings and issues requiring clarification. Emphasis is given to precise histopathological definitions, histopathological detection and differential diagnosis. The approach is a practical one--a consideration of common experiences and dilemmas faced by the reporting pathologist, and where possible, we offer guidance and practical tips. The article concludes with a brief consideration of the prognostic value of accurate histopathological staging
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