1,720,973 research outputs found
Utilizzo del bisturi di Chardonnens e del “morcellement” nella miomectomia laparoscopica
Full text linkSi riferisce l’esperienza, maturata in 10 anni, riguardante la tecnica chirurgica impiegata in 191 miomectomie laparoscopiche eseguite su donne con attesa di fertilità. In relazione all’isterotomia di accesso al mioma, le pazienti sono state divise in due gruppi. Nel primo (52 pazienti) è stata utilizzata l’elettroresezione monopolare e bipolare, nel secondo (139 pazienti) è stato utilizzato il bisturi a lama fredda di Chardonnens. Nelle pazienti successivamente operate per taglio cesareo o sottoposte a laparoscopia diagnostica appartenenti al secondo gruppo la frequenza di aderenze utero-pelviche è stata del 15,78%, rispetto al 27,27% in analoghe pazienti appartenenti al primo gruppo. Tale riscontro, rilevante in pazienti con attesa di fertilità, ha motivato l’abbandono dell’elettroresezione a favore dell’utilizzo del bisturi di Chardonnens negli interventi di miomectomia laparoscopica. Un ulteriore vantaggio nella salvaguardia dell’integrità morfologica e funzionale della parete uterina è venuto dall’impiego delle tecniche di “morcellement” e di “rolling” nell’asportazione dei miomi
Optimizing MOF properties for seasonal heat storage: a machine learning approach
Full text linkIn the quest to enhance thermochemical energy storage using promising sorbents, this work presents a study on the optimization of Metal Organic Frameworks (MOFs) properties for gas sorption, with a focus on CO2 and H2O adsorption. Through the analysis of crystallographic descriptors, the study aims to streamline the selection of MOFs that could potentially exceed the performance of existing water sorbent pairs. A comprehensive comparison of sequential learning (SL) algorithms reveals a method for identifying the minimal set of descriptors that influence adsorption properties of MOFs. The protocol involves constructing and training machine learning (ML) models to determine the number of influential descriptors and utilizing SHAP analysis to evaluate their importance. Findings suggest that including only these critical descriptors in the exploration space reduces computational load. Notably, the COMBO and the FUELS algorithms consistently outshine random guessing, validating their efficacy in materials optimization. The challenge of accessing full adsorption properties across the entire coverage range is addressed by a computational screening procedure requiring minimal input data. This method suggests that some vanadium based MOFs, originally designed for different purposes, could surpass the current leading compounds for thermal energy storage, primarily due to their optimal Henry coefficient values for water adsorption
Glia-neuron interplay in health and disease: pharmacological evidence for this required teamwork
Full text linkGlia is a cell population highly present in the central nervous system (CNS) with the purpose, among other functions, to support neurons. In fact, many of these cells are closely in contact with neurons, actively participating to homeostatic support and synaptic transmission. For instance, astrocytes are considered integral part of the tripartite synapse. By this way, recent discoveries made possible to change perspective regarding the neuro-centric view of chronic neurodegenerative disorders, expanding the horizon to new players involved in the physiological and/or pathologic processes that take place in CNS. Better understanding the contribution of non-neuronal cells to these processes will be crucial for the development of new therapeutic approaches to counteract neurodegeneration.
Moving from these assumptions, my studies focused on evaluating the role of glial cells in inducing and triggering the inflammatory processes during neurodegeneration and, in particular, on the events that lead these cells to an activated state named reactive gliosis. Moreover, the consequences caused by these processes on neuronal survival, and in a macroscopic manner, on learning and memory, were evaluated.
To achieve such goals, I worked with different preclinical models of AD, both in vitro and in vivo, attempting to recreate at best the pathological hallmarks of pathology. In addition, since the crucial role of glial cells in the maintenance of brain homeostasis and their close connection with neuronal functioning and survival, the action of different molecules on neuroinflammation, as well as on neuronal survival, were tested
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Dalla gravidanza a sede indeterminata alla gravidanza extrauterina: condotta clinica ed esperienza personale
Full text linkGli Autori analizzano il periodo intercorrente tra la positività del test di laboratorio e l’eventuale osservazione ecografica di una camera gestazionale in utero.
L’utilizzo di tecnologie sempre più evolute e il lavoro di gruppi di sanitari qualificati permette di monitorare attentamente questa fase della gravidanza prevenendo ed eliminando rischi per la salute e, talora, la vita della gestante. Sono riassunte le più recenti acquisizioni nella condotta clinica della gravidanza a sede indeterminata (Pregnancy of Unknown Location - PUL) e le più recenti evoluzioni nella gestione della Gravidanza ExtraUterina (GEU), patologia che non sempre riscontra univocità di trattamento nelle diverse realtà organizzative. Invece, l’adozione di un management collaudato e basato sull’evidenza può servire a uniformare la condotta degli operatori su un percorso diagnostico e terapeutico efficace
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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