1,721,296 research outputs found
Response to the Letter to the Editor Re: Pizzato S, Trevisan C, Lucato P, et al. Identification of asymptomatic frailty vertebral fractures in post-menopausal women
No full textIdentification of asymptomatic frailty vertebral fractures in post-menopausal wome
Prospettive nell’uso dei bisfosfonati per la prevenzione della perdita ossea periprotesica.
No full textAre cognitive disorders more common in geriatric diabetic patients? What factors contribute to cognitive decline?
No full textCognitive screening is recommended for all geriatric DM patients. Suggested validated screening tests are the Short Portable Mental Status Questionnaire and the clock drawing test. Screening should be repeated on a twice-yearly basis in those who are borderline and annually in those who are negative. In the case of positive screening, a specialist clinical diagnostic assessment is recommended.
In patients with mild cognitive impairment and dementia, evaluating and treating possible modifiable risk factors is recommended, such as sensory and physical functional disorders, obstructive sleep apnea syndrome, etc.
Simplification of antidiabetic drug treatment is also recommended in these patients
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Exercise-induced recurrent myoglobinuria: Defective activity of inner carnitine palmitoyltransferase in muscle mitochondria of two patients
No full textIn carnitine palmitoyltransferase (CPT) deficiency, it is not known whether the outer (CPT-I) and the inner (CPT-II) mitochondrial activities are equally altered. By two different assays, we found that CPT activity in fresh intact mitochondria of two patients was normal or increased, indicating an active outer CPT. In controls and in one of the two patients, the isotope-exchange assay was also evaluated after disruption of mitochondria by sonication: in controls the activity almost doubled because of the contribution of inner CPT to the assay, but in the patients it did not increase, indicating absence of the CPT-II activity. After further disruption of mitochondria by freezing and all-glass homogenization, CPT activity in patients decreased to 36% and 10% of control. These data suggest that CPT deficiency was limited to the inner mitochondrial activity. The alteration could be explained by mutation of the membrane factor that determines in situ differences between CPT-I and II. © 1987 American Academy of Neurology
Clinical Features of SARS-CoV-2 Infection in Older Adults
No full textThe COVID-19 clinical presentation is extremely heterogenous and, in older people, it is influenced not simply by chronologic age but also by common geriatric syndromes, such as multimorbidity, motor disability, and frailty. Consequently, although typical respiratory symptoms remain the most frequent clinical presentation of COVID-19 in all age classes, in older patients, atypical symptoms (including but not limited to delirium and hyporexia) are more common than in middle-aged adults and have been associated with adverse outcomes. Moreover, some studies described the tendency of COVID-19 presenting symptoms to aggregate in clusters, and this approach seems to better capture the complexity of COVID-19 disease. The prognostic value of COVID-19 symptom clusters, however, is currently poorly investigated, especially in the older population
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