1,721,348 research outputs found
Emergency call from gynecologists: how to treat restless legs syndrome during pregnancy?
No full textParkinson's Syndrome in Old Age - Symptom Variability and atypical clinical Presentation
No full textParkinson's Syndrome in Old Age - Symptom Variability and atypical clinical Presentation
No full textUpdate for the pathophysiology for the restless legs syndrome
No full textThe Restless Legs Syndrome (RLS) is a heterogeneous disease. The so-called idiopathic RLS syndromes affect preferentially younger patients before the age of 30 and are with a higher likelihood familial. This year intronic variants in the homeobox gene MEIS1, the BTBD9 gene encoding a BTB(POZ) domain as well as variants in a third locus containing the genes encoding mitogen-activated protein kinase MAP2K5 and the transcription factor LBXCOR1 on chromosomes 2p, 6p and 15q, were identified. Symptomatic or secondary forms encompass iron deficiency, uremia, polyneuropathy and other causes. At present it is of particular interest to unravel why dopaminergic therapy is so efficient in the disease and why it leads to augmentation in some patients. Augmentation can be defined as a therapy induced paradoxical symptom severity increase caused by dopaminergic therapy. Augmentation occurs in about 60% of patients preferentially on L-Dopa, but also on therapy with dopamine agonists. It is probably caused by a relative shift of the balance between excitatory dopaminergic D1-receptors and inhibitory D2-receptors at a spinal level. Iron deficiency is an initiating or strengthening factor. Therapy with L-Dopa or dopamine agonists should remain at distinctly lower doses than those commonly used in Parkinson's disease. Iron substitution and opiates are drugs of choice to minimize the risk of augmentation
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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