1,721,090 research outputs found
Molecular characterization of grey zone lymphomas
No full textLe lymphome de forme frontière (LFF) entre lymphome de Hodgkin classique (LHC) et lymphome B à grandes cellules (LBGC), a été introduit dans la classification OMS en 2008. Cependant, les critères diagnostiques restent discutés par les cliniciens et les pathologistes. Nous avons émis l’hypothèse qu’une meilleure caractérisation sur le plan moléculaire de ces cas permettrait de redéfinir une classification reposant sur des bases biologiques communes. Dans le cadre d’une relecture centralisée, nous avons réunis une cohorte rétrospective internationale et revisité les critères diagnostiques au sein d’un spectre entre LHC et LBGC afin de fournir un cadre pour les analyses moléculaires. Grâce à l’étude du profil d’expression génique, nous avons pu déterminer que le statut EBV et la présence d’un envahissement thymique étaient responsable d’une grande part de la variance au sein du spectre. Une caractérisation du microenvironnement tumoral a pu définir que l’infiltrat macrophagique était un élément clé dans les LFF. L’étude des anomalies moléculaires a permis de confirmer la séparation nette entre ces formes de LFF. Au total, ce travail a permis de redéfinir la classification des LFF sur une assise biologique solide, apportant un rationnel pour le développement de thérapies ciblées en fonction des sous-groupesGrey zone lymphoma (GZL) with features intermediate between classical Hodgkin lymphoma (cHL) and large B cell lymphoma (LBCL) was introduced into the WHO classification in 2008. However, since diagnostic criteria are imprecise, reliable identification and treatment of GZL cases remains challenging. With the hypothesis that molecular biology could provide a deeper insight into the biology of this entity, we aimed at providing a new framework for the classification of GZL. We first collected an international cohort of centrally reviewed GZL cases and provided refined diagnostic criteria which contribute to a more precise characterization within a broad spectrum from cHL-like to LBCL-like disease. Thanks to RNA sequencing, we discovered that EBV status and thymic involvement were major driver of the variance of the gene expression profiling within the spectrum. A detailed characterization of tumor microenvironment showed that macrophage infiltrate is a key feature of GZL. Then, we further confirmed the split observed at the phenotypic level with fully distinct mutational landscape for thymic and non-thymic GZL, as well as for EBV associated cases. In conclusion, we provided the framework for an evolution in the classification of GZL and project that our findings might have implications for clinical decision making in the future given the increasing role of modern approaches involving tailored therapie
Lymphomes B de la zone marginale ganglionnaire (revue de la littérature et analyse d'une série de 24 patients)
No full textLYON1-BU Santé (693882101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
Histoséminaire « Apport des nouvelles techniques de biologie moléculaire dans le diagnostic des lymphomes : mythe ou réalité ? ». Cas no 1 : Lymphome B de haut grade avec aberration 11q
No full textInternational audienc
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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