1,720,961 research outputs found
Base‐Paired i‐Motif
Get PDFDNA sequences containing at least four runs of repetitive cytosines can fold into tetra-helical struc-tures called i-Motifs (iMs). The interest in these DNA secondary structures is increasing due to their therapeut-ical and technological applications. Still, limited knowl-edge of their folding requirements is currently available. We developed a novel step-by-step pipeline for the systematic screening of putative iM-forming model sequences. Focusing on structures comprising only three cytosine-cytosine+ base pairs, we investigated what the minimal lengths of the loops required for formation of an intra-molecular iM are. Our data indicate that two and three nucleotides are required to connect the strands through the minor and majorgrooves of the iM, respectively. Additionally, they highlight an asymmetric behavior according to the distribution of the cytosines. Specifically, no sequence containing a single cytosine in the first and third run was able to fold into intra-molecular iMs with the same stability of those formed when the first and the third run comprise two cytosines. This knowledge represents a step forward toward the development of prediction tools for the proper identi-fication of biologically functional iMs, as well as for the rational design of these secondary structures as techno-logical devices
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Conceptual design of wastewater and stormwater drainage in the Klisa settlement in Bosnia and Herzegovina
No full textŽivimo v obdobju, v katerem človekove dejavnosti močno vplivajo na vsak del narave. Voda je del narave, in kot vemo, je pogoj za preživetje človeka. Rečni tokovi so se v zadnjih 10 letih pomembno spremenili, z izrazitimi obdobji suše in poplav. V različnih delih sveta, kot sta Afrika in Azija, so se pojavili meddržavni konflikti zaradi vodnih virov. Jasno je, da ima voda nacionalni pomen za vsako državo. Glavni cilj te magistrske naloge je zaščita reke Une in izboljšanje kakovosti vode.
Magistrska naloga se ukvarja z izdelavo idejno rešitve odvajanja odpadnih voda in padavinskih vod iz naselja Klisa, ki se nahaja v Bosni in Hercegovini. Samo naselje Klisa leži v strogem zaščitenem območju Nacionalnega parka Una. Poleg naselja Klisa teče reka Una, ki ima po zakonu o zaščiti nacionalnega parka status kopalne vode.
V sami magistrski nalogi sta razviti dve možni rešitvi odvajanja odpadne vode. Problematika je najprej teoretično obrazložena, nato so navedene vse specifikacije problema in na koncu je, v skladu z obstoječo zakonodajo, izvedena tehnično-ekonomska analiza. Pri tem so uporabljena različna programska orodja, kot so CIVIL 3D, QGIS, EXCEL itd. S tem je bilo dokazano, da bo z izgradnjo kanalizacije ta projekt prispeval k zaščiti vode reke Une na tem območju.We live in an era where human activities strongly influence every aspect of nature. Water is a part of nature and, as we know, a necessity for human survival. River flows have significantly changed in the last 10 years, with pronounced periods of drought and floods. In various parts of the world, such as Africa and Asia, interstate conflicts have arisen due to water resources. Water has a national significance for every country. The main goal of this master\u27s thesis is the protection of the Una River and the improvement of water quality.
This master\u27s thesis deals with the development of a conceptual solution for the drainage of wastewater and rainwater from the settlement of Klisa, located in Bosnia and Herzegovina. The Klisa settlement itself is situated within the strictly protected area of the Una National Park. Additionally, the Una River flows next to the Klisa settlement, which, according to the law on the protection of the national park, holds the status of protected water.
Within the master\u27s thesis, two possible solutions to the wastewater drainage problem are developed. The issues are first theoretically explained, followed by the specifications of the problem, and finally, a technical-economic analysis is carried out. Various software tools such as CIVIL 3D, QGIS, EXCEL, etc., were used in the process. This demonstrates that with the construction of the sewage system, this project will contribute to the protection of the Una River water in this area
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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