1,721,070 research outputs found
Correction to: Surgical correction of double major adolescent idiopathic scoliosis
No full textUnfortunately, the affiliation of the author group has been incorrectly published in original version. The complete correct affiliation of all authors should read as follows
Correction to: Spino-pelvic balance and surgical treatment of L5-S1 isthmic spondylolisthesis
No full textUnfortunately, the affiliation of the author group has been incorrectly published in original version. The complete correct affiliation of all authors should read as follows
Fracture of ceramic bearing surfaces following total hip replacement: A systematic review
No full textCeramic bearing surfaces are increasingly used for total hip replacement, notwithstanding that concern is still related to ceramic
brittleness and its possible mechanical failure. The aim of this systematic review is to answer three questions: (1) Are there risk
factors for ceramic component fracture following total hip replacement? (2) Is it possible to perform an early diagnosis of ceramic
component failure before catastrophic fracture occurs? (3) Is it possible to draw guidelines for revision surgery after ceramic
components failure? A PubMed and Google Scholar search was performed and reference citations from publications identified
in the literature search were reviewed. The use of 28 mm short-neck femoral head carries an increased risk of fracture. Acetabular
component malposition might increase the risk of ceramic liner fractures. Synovial fluid microanalysis and CT scan are promising
in early diagnosis of ceramic head and liner failure. Early revision is suggested in case of component failure; no consensus exists
about the better coupling for revision surgery. Ceramic brittleness remains a major concern. Due to the increased number of ceramic
on ceramic implants, more revision surgeries and reports on ceramic components failure are expected in the future. An algorithm
of diagnosis and treatment for ceramic hip failure is proposed
Biopolymer Recovery from Aerobic Granular Sludge and Conventional Flocculent Sludge in Treating Industrial Wastewater: Preliminary Analysis of Different Carbon Routes for Organic Carbon Utilization
Full text linkThe recovery of biopolymers from sewage sludge could be a crucial step in implementing circular economy principles in wastewater treatment plants (WWTP). In this frame, the present study was aimed at evaluating the simultaneous production of polyhydroxyalkanoates (PHA) and extracellular polymeric substances (EPS) obtainable from the treatment of agro-industrial wastewater. Two biological enrichment systems, aerobic granular sludge (AGS) and a conventional activated sludge operating as a sequencing batch reactor (SBR), were monitored for 204 and 186 days, respectively. The maximum biopolymers accumulation capacity was close to 0.60 mgPHA-EPS gVSS−1 in the AGS when operating at 3 kgCODm−3d−1, whereas in the SBR, it was about half (0.35 mgPHA-EPS gVSS−1). Biopolymers extracted from the AGS were mainly constituted by EPS (>70%), whose percentage increased up to 95% with the OLR applied in the enrichment reactor. In contrast, SBR enabled obtaining a higher PHA production (50% of the biopolymers). Results suggested that organic carbon was mainly channeled toward metabolic pathways for extracellular storing in AGS, likely due to metabolic stressors (e.g., hydraulic selection pressure, shear forces) applied for promoting aerobic granulation
Environmental commitment of large US publicly traded companies producing healthcare equipment: a cross-sectional comparative study
No full textThe environmental commitment of healthcare stakeholders is poorly described despite the sector pollution and the social needs of more sustainable behaviors. A cross-sectional study comparing the environment commitment of US publicly traded companies producing healthcare equipment (HE), healthcare companies (H), and large capitalization corporates (LC) was designed. Using a financial database, the 20 largest US publicly traded companies by market capitalization were selected for each cohort. The last available sustainability report was investigated, aiming to assess (1) the year and the method of dissemination of the last report; (2) the adhesion to environmental standards; (3) the presence of environmental policies, quantitative targets, and tracking; (4) the third-party evaluations about company environmental sustainability. HE companies published sustainability reports in time (p = 0.048), usually as standalone reports (p < 0.001). Half of HE companies adhered to standards, less than the control groups (p < 0.001). HE companies had an acceptable environmental policy, improving over the time and posing targets, similarly to control groups (p > 0.05). The number of companies reporting quantitative targets/tracking about carbon footprint, water, and renewable energy managements differed among the three cohorts (p = 0.013, p = 0.013, and p < 0.001, respectively), with HE cohort achieving the lowest rates (70%, 70%, and 50%, respectively). Carbon neutrality and all renewable energy statements were rare among HE companies (10% and 5% of companies, p < 0.007). In HE, CDP (The Carbon Disclosure Project) scores were lower than controls (p < 0.001). US publicly traded companies producing healthcare equipment demonstrated to be far less committed to environmental sustainability than healthcare companies and large capitalization corporates. Level of evidence: I
Effect of different motor tasks on hip cup primary stability and on the strains in the periacetabular bone: An in vitro study
No full textBackground: Excessive prosthesis/bone motions and the bone strains around the acetabulum may prevent osteointegration and lead to cup loosening. These two factors depend on post-operative joint loading. We investigated how Walking (which is often simulated) and Standing-Up from seated (possibly more critical) influence the cup primary stability and periacetabular strains.
METHODS:
Twelve composite hemipelvises were used in two test campaigns. Simplified loading conditions were adopted to simulate Walking and Standing-Up. For each motor task, a single-direction force was applied in load packages of increasing amplitude. Stable and unstable uncemented cups were implanted. Digital image correlation was used to measure implant/bone motions (three-dimensional translations and rotations, both permanent and inducible), and the strain distribution around the acetabulum.
FINDINGS:
When stable implants were tested, higher permanent cranial translations were found during Walking (however the resultant migrations were comparable with Standing-Up); higher rotations were found for Standing-Up. When unstable implants were tested, motions were 1-2 order of magnitude higher. Strains increased significantly from stable to unstable implants. The peak strains were in the superior aspect of the acetabulum during Walking and in the superior-posterior aspect of the acetabulum and at the bottom of the posterior column during Standing-Up.
INTERPRETATION:
Different cup migration trends were caused by simulated Walking and Standing-Up, both similar to those observed clinically. The cup mobilization pattern depended on the different simulated motor tasks. Pre-clinical testing of new uncemented cups could include simulation of both motor tasks. Our study could also translate to indication of what tasks should be avoided
A reliable in vitro approach to assess the stability of acetabular implants using digital image correlation
No full textThe main cause of failure of the hip acetabular component is aseptic loosen- ing. Preclinical test methods currently used to assess the stability of hip acetabular implants rely on crude simplifications. Normally, either one com- ponent of motion or bone strains are measured. We developed a test method to measure implant 3D translations and rotations and bone strains using digital image correlation. Hemipelvises were aligned and potted to allow consistent testing. A force was applied in the direction of the load peak during level walking. The force was applied in 100‐cycle packages, each load package being 20% larger than the previous one. A digital image correlation system allowed measuring the cup‐bone relative 3D displacements (permanent migra- tions and inducible micromotions) and the strain distribution in the periacetabular bone. To assess the test repeatability, the protocol was applied to six composite hemipelvises implanted with very stable cups. To assess the suitability of the method to detect mobilisation, six loose implants were tested. The method was repeatable: the interspecimen variability was 16 μm for the bone/cup relative translations, 0.04° for the rotations. The method was capa- ble of tracking extremely loose implants (translations up to 4.5 mm; rotations up to 30°). The strain distribution in the bone was measured, showing the areas of highest strain. We have shown that it is possible to measure the 3D relative translations and rotations of an acetabular cup inside the pelvis and simultaneously to measure the full‐field strain distribution in the bone sur- face. This will allow better preclinical testing of the stability of acetabular implants
Inflammatory Biomarkers and Gait Impairment in Older Adults: A Systematic Review
Full text link: Peripheral inflammation and gait speed alterations are common in several neurological disorders and in the aging process, but the association between the two is not well established. The aim of this systematic literary review is to determine whether proinflammatory markers are a positive predictor for gait impairments and their complications, such as falls in older adults, and may represent a risk factor for slow gait speed and its complications. The systematic review was performed in line with the Preferred Report Items for Systematic Review and Meta-Analyses (PRISMA). A protocol for literature searches was structured a priori and designed according to the International Perspective Register of Systemic Review (PROSPERO: CRD42023451108). Peer-reviewed original articles were identified by searching seven electronic databases: Excerpta Medica Database (EMBASE), SciVerse (ScienceDirect), Scopus, PubMed, Medline, Web of Science, and the Cochrane Library. The search strategy was formulated based on a combination of controlled descriptors and/or keywords related to the topic and a manual search was conducted of the reference lists from the initially selected studies to identify other eligible studies. The studies were thoroughly screened using the following inclusion criteria: older adults, spatiotemporal gait characteristics, and proinflammatory markers. A meta-analysis was not performed due to the heterogeneity of the studies, and the results were narratively synthesized. Due to the clinical and methodological heterogeneity, the studies were combined in a narrative synthesis, grouped by the type of biomarkers evaluated. A standardized data extraction form was used to collect the following methodological outcome variables from each of the included studies: author, year, population, age, sample size, spatiotemporal gait parameters such as gait velocity, and proinflammatory markers such as TNF-α, high sensitivity C-reactive (CRP) proteins, and IL-6. We included 21 out of 51 studies in our review, which examined the association between inflammatory biomarkers and gait impairment. This review highlights the role of TNF-α, CRP, and IL-6 in gait impairment. Biomarkers play an important role in the decision-making process, and IL-6 can be an effective biomarker in establishing the diagnosis of slow gait speed. Further longitudinal research is needed to establish the use of molecular biomarkers in monitoring gait impairment
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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