1,720,985 research outputs found
Burden of Inflammatory Skin Diseases Based on GBD Data: China vs USA
No full textOpen-Access-Publikationsfonds 202
data analysis 2009–2018
Full text linkBACKGROUND
Allergic contact dermatitis caused by shoes is common and new relevant allergens have been identified.
OBJECTIVES
To investigate the pattern of type IV sensitization in patients with suspected allergic contact dermatitis of the feet related to shoes as a presumed culprit trigger.
METHODS
Retrospective analysis of data of the Information Network of Departments of Dermatology (IVDK), 2009-2018.
RESULTS
Six hundred twenty-five patients with presumed shoe dermatitis were identified in a cohort of 119 417 patients. Compared to patients with suspected contact sensitization from other allergen sources (n = 118 792), study group patients were more frequently sensitized to potassium dichromate (10.8% vs 3.5%), colophony (7.2% vs 3.7%), mercaptobenzothiazole (MBT; 4.0% vs 0.6%), mercapto mix (4.6% vs 0.6%), and p-tert-butylphenol formaldehyde resin (1.6% vs 0.5%). Sensitizations to urea formaldehyde resin, melamine formaldehyde resin, glutaraldehyde, tricresyl phosphate, and phenyl glycidylether were rare. Moreover, reactions to compounds in the leather or textile dyes test series were scarce.
CONCLUSION
A distinct sensitization pattern was observed in patients with suspected allergy to shoe materials. Although substances with low sensitization rates should be removed from the leather and shoe patch test series, novel potential allergens should be added
Dupilumab Improves Clinical Symptoms and Biomarkers in Comorbid Seasonal Timothy Grass Pollen Allergic Rhinitis in Patients With CRSwNP
No full textSymptom severity reflected by NYHA grade is independently associated with pruritus in chronic heart failure patients
No full textAbstract
Background
Pruritus is a symptom profoundly impairing patients' quality of life (QoL). It is a common symptom in chronic heart failure (CHF) patients of yet unknown nature. The aim of this study was to evaluate the risk factors of pruritus in CHF patients.
Methods
For this monocentric, prospective cohort study, CHF patients were recruited and CHF symptoms, comorbidities and drug intake were assessed using a structured report. Additionally, a questionnaire evaluated pruritus symptoms. Detailed medical histories including laboratory test results were retrieved from patient files for all participants.
Results
We evaluated data from 550 CHF patients. Of those, 25.3% reported pruritus to occur frequently (3–5 times per week), often (1–2 times per week) or daily. Patients of higher NYHA classes (NYHA III + IV) experienced significantly more pruritus (31.2%) than lower NYHA classes (NYHA I + II) (21.1%,
p
= 0.024). Patients with pruritus reported disproportionately often concomitant stasis dermatitis (
p
= 0.026) and chronic lung disease (
p
= 0.014). Other parameters reflecting cardiac, liver, kidney and thyroid function, as well as medical therapies showed no significant differences between patients with and without pruritus. In the multivariate logistic regression analysis, only NYHA class (
p
= 0.016, OR 1.55, 95% confidence interval (CI): [1.09; 2.20]) and elevated leukocyte count (
p
= 0.007, OR 1.11, CI [1.03; 1.21]) remained significantly associated with pruritus in CHF patients.
Conclusions
NYHA class is an independent predictor for pruritus in CHF patients. Besides NYHA class, leukocyte count was also associated with increased pruritus. Pruritus may impair QoL in CHF patients and should thus be included in the assessment of those patients. We suggest that providing best care for CHF patients can be achieved through an interdisciplinary approach of cardiologists and dermatologists and should include a pruritus assessment
Handekzemsymptome, Expositionen und Hautpflege in der Kieferorthopädie
No full textObjectives
Occupational hand eczema is a common inflammatory skin condition among healthcare professionals. Orthodontists are frequently exposed to a variety of irritating and allergenic substances, and therefore they belong to a predisposed group to develop hand eczema. However, current data on the prevalence and predisposing factors among orthodontists to provide adequate prophylaxis are lacking.
Methods
An anonymous online survey was conducted in Germany between January and February 2023 and distributed to 2402 orthodontists. The questionnaire addressed general information on current skin status, as well as occupational skin exposure and skin care.
Results
A total of 209 orthodontists responded to the survey. Seventy-four percent reported experiencing hand eczema-specific symptoms within the last 12 months, with 24% describing moderate and 10% describing severe symptoms. The average daily glove wearing time was stated to be 6 ± 2 h. The most frequently reported triggers at work were frequent hand washing (62.7%) and hand disinfection (59.1%). Among all the respondents, 22.6% stated not using either barrier cream or moisturizer.
Conclusions
This study showed a high prevalence of hand eczema symptoms among orthodontists, which is probably due to frequent disinfection, hand washing, and contact with allergens such as acrylates. In this professional group especially, against a background of future increasing acrylate and epoxy resin exposures due to in-office three-dimensional printing processes, timely education and skin protection could decisively counteract the pathogenesis of hand eczema.Zielsetzung
Das berufsbedingte Handekzem ist eine häufige entzündliche Hauterkrankung bei Heilberufstätigen. Kieferorthopäd*innen sind häufig einer Vielzahl von reizenden und allergenen Substanzen ausgesetzt und gehören daher zu einer prädisponierten Gruppe für die Entwicklung eines Handekzems. Es fehlen jedoch aktuelle Daten über die Prävalenz und prädisponierende Faktoren bei Kieferorthopäd*innen, um eine angemessene Prophylaxe zu gewährleisten.
Methoden
Eine anonyme Online-Umfrage wurde zwischen Januar und Februar 2023 in Deutschland durchgeführt und an 2402 Kieferorthopäden verschickt. Der Fragebogen adressierte allgemeine Informationen zum aktuellen Hautstatus sowie zu beruflich bedingter Hautexposition und Hautpflege.
Ergebnisse
Insgesamt 209 Kieferorthopäd*innen nahmen an der Umfrage teil. Vierundsiebzig Prozent gaben an, in den letzten 12 Monaten an handekzemspezifischen Symptomen gelitten zu haben, wobei 24% moderate und 10% schwere Symptome beschrieben. Die durchschnittliche tägliche Tragezeit von Handschuhen wurde mit 6 ± 2 h angegeben. Die am häufigsten genannten Auslöser bei der Arbeit waren häufiges Händewaschen (62,7%) und Händedesinfektion (59,1%). Von allen Teilnehmenden gaben 22,6% an, weder Hautschutz- noch Feuchtigkeitscremes zu verwenden.
Schlussfolgerung
Die Studie ließ eine hohe Prävalenz von Handekzemsymptomen bei Kieferorthopäd*innen beobachten, was wahrscheinlich auf häufiges Desinfizieren und Händewaschen sowie den Kontakt mit Allergenen, wie Acrylaten, zurückzuführen ist. Vor dem Hintergrund der zukünftig zunehmenden Acrylat- und Epoxidharzbelastung durch 3‑D-Druckverfahren in der Praxis könnte gerade in dieser Berufsgruppe durch rechtzeitige Aufklärung und Hautschutz der Pathogenese des Handekzems entscheidend entgegengewirkt werden
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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