794 research outputs found
Self-Renewal of Macrophages: Tumor-Released Factors and Signaling Pathways
No full textMacrophages are the most abundant immune cells of the tumor microenvironment (TME) and have multiple important functions in cancer. During tumor growth, both tissue-resident macrophages and newly recruited monocyte-derived macrophages can give rise to tumor-associated macrophages (TAMs), which have been associated with poor prognosis in most cancers. Compelling evidence indicate that the high degree of plasticity of macrophages and their ability to self-renew majorly impact tumor progression and resistance to therapy. In addition, the microenvironmental factors largely affect the metabolism of macrophages and may have a major influence on TAMs proliferation and subsets functions. Thus, understanding the signaling pathways regulating TAMs self-renewal capacity may help to identify promising targets for the development of novel anticancer agents. In this review, we focus on the environmental factors that promote the capacity of macrophages to self-renew and the molecular mechanisms that govern TAMs proliferation. We also highlight the impact of tumor-derived factors on macrophages metabolism and how distinct metabolic pathways affect macrophage self-renewal
Interview with Cathy Ulrich
No full textThis spring, the students in UND’s ENGL 414 workshop (The Art of Writing Fiction) read a collection of micro and flash fictions titled Ghosts of You, by Cathy Ulrich. With its use of second person and a penchant for turning tropes of crime fiction on their heads, this book is a must read. Three ENGL 414 students had the opportunity to interview the author via email to discuss Cathy Ulrich’s intentions in Ghosts of You, as well as her own personal writing techniques. To borrow from how each story in Ghosts of You begins, “The thing about being the [interviewer] is you set the plot in motion.” Floodwal
History of Education in Manatee County
No full textLocal historian and author, Cathy Slusser, discusses the history of early education in Manatee County
Outer Cover : Dedicated to Cathy
No full textThe cover states that the design was dedicated to the American girl "Cathy" who had showed the author "Where It's At".The cartoon serves as a vinyl cover which includes all the artists part of the release. There is no clear indication of a title although a list of songs and musicians have been included
Migrant Health: A Key Issue For Global Health - 25 May 2011
No full textLONDON - Good health care for the one billion migrants around the world is vital if global health for all is to be achieved and maintained, according to Cathy Zimmerman of the Gender Violence and Health Centre at The London School of Hygiene & Tropical Medicine - author of the first article in a series devoted to Migration And Health in the medical journal: PLoS Medicine, for which she is one of the editors
Young people's help-seeking: an alternative model
No full textThis article is based on a study of young people's help-seeking. Fifty-five qualitative interviews with young people aged 13–14 are analysed to take account of stage process models. It is argued that while the models do have relevance to young people's help-seeking, they have two key limitations. First, they ignore problem legitimization. Second, they do not accord a place in young people's currenthelp-seeking to prior help-seeking pathways. The view that stage process models represent help-seeking as individualized and static led to the formulation by the author of an alternative help-seeking model, in which problem legitimization from micro to macro levels is incorporated alongside young people's prior helpseeking pathways. <br/
The Hormone of Desire: The Truth Sexuality, Menopause and Testosterone (bookcover)
No full textJacket design by Susan Mitchell Cover photograph © Sky Bergman Author photograph by Cathy Copelan
Interview with Armando Hugo Ortiz Guerrero
No full textCathy Ragland interviews music historian and author, Armando Hugo Ortiz Guerrero.https://scholarworks.utrgv.edu/cathyraglandrec/1003/thumbnail.jp
Narratives of Collaboration in Post-War France, 1944 – 1974
No full textArguing that literary narratives (whether fictional or autobiographical) can provide an important way in which the past is accessed and understood, this thesis uses such narratives to compare and contrast cultural representations of collaboration with the Gaullist political accounts described in Henry Rousso’s Le Syndrome de Vichy. Following the introduction, chapter one examines the perception and characteristics of collaboration, providing a broad analysis of collaboration and collaborators which frames later chapters. There follows a discussion of the generic boundaries between history, autobiography and fiction, showing that novels can contain many of the attributes conventionally ascribed to historical texts, as well as having a freedom of form which allows them to examine and relate subjects not allowed to historical accounts. Next, selected novels (by Marcel Aymé, Jean-Louis Bory, Marie Chaix, Céline, Jean-Louis Curtis, Jean Dutourd, Pascal Jardin, Patrick Modiano, Saint-Loup, and Michel Tournier) are analysed at length to examine how specific forms of collaboration have been understood, and how they subvert Rousso’s schema of repression or marginalisation of the phenomenon. Novels written in the immediate aftermath of the war actually gave a convincing representation of collaboration and the everyday wartime experience, contrasting with the ‘official’ story which sought to forget collaboration. Representations of intellectual and cultural collaboration show that, contrary to de Gaulle’s attempts to portray France as a nation of resisters, high-profile figures from these circles offered a more persuasive alternative to this view. This is also shown to be the case for depictions of military and paramilitary collaboration, which openly describe armed and violent collaboration, challenging and contrasting with the Gaullist representation of mass resistance supported by the civil population. Finally, familial memories are used to revaluate the mode rétro in light of earlier chapters. Although this phenomenon found innovative ways to view the war, it did not represent a wholly new, or more open, account, and was subject to its own repressions and distortions
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