3,504 research outputs found
Resilience and phenotypic plasticity of Arctic char (Salvelinus alpinus) facing cyclic hypoxia: Insights into growth, energy stores and hepatic metabolism
No full textDucros, Touaibia, Pichaud and Lamarre Published in Conservation Physiology 202
Sinapic and ferulic acid phenethyl esters increase the expression of steroidogenic genes in MA-10 tumor Leydig cells
No full textDuring aging, the production of androgens by the testis Leydig cells gradually decreases. Phenolic compounds can improve testosterone biosynthesis and delay the onset of hypogonadal symptoms in males. In this study, sinapic acid phenethyl ester was evaluated for its ability to regulate gene expression and steroid production in Leydig cells. Specifically, the effects of this ester on the transcriptome of MA-10 Leydig cells were investigated by RNA-Seq. To better establish a structure-function relationship of the hydroxy-methoxyphenyl moiety of sinapic and phenethyl ester, its influences on gene expression were compared to those of its ferulic acid phenethyl ester analogue. According to the transcriptomic analysis, most genes encoding enzymes related to cholesterol biosynthesis are increased in response to sinapic acid phenethyl ester treatment of MA-10 Leydig cells. Interestingly, treatments with 10 μM of ferulic acid phenethyl ester increased cAMP-dependent Star promoter activation, gene expression and protein levels. In addition, treatments of MA-10 Leydig cells with 10 μM of sinapic or ferulic acid phenethyl ester resulted in increased progesterone production. Thus, our results indicate that sinapic and ferulic acid phenethyl esters can improve cholesterol and steroid biosynthesis in testicular Leydig cells.udemauteur: Mohamed Touaibia; Luc Marti
Phonation in Somali phonology
No full textThe author presents a phonological study on Somali language, in particular it focuses on the binary feature voiced/unvoiced stating its inadequacy.Qoraagu wuxuu halkan ku muujinayaa daraasaad ku saabsan codaynta Af-soomaaliga, wuxuuna si gaar ah diiradda u saarayaa labada qaab codlle/codlaawe oo aan is lahayn.L'autore presenta uno studio fonologico sulla lingua somala: in particolare definisce il tratto binario sonoro/sordo inadeguato ad un'esauriente descrizione della lingua.Mohamed Mohamed Abdi (a cura di
Hautverdächtig
No full textBook Title: Postcolonial Studies; Racial Profiling
Chapter Title: Hautverdächtig
Author(s): Mohamed Wa Baile, Ellen Höhne
Publisher: transcript Verlag
DOI: 10.14361/9783839441459-004
ISBN(s): 978-3-8376-4145-5, 978-3-8394-4145-9
ISSN(s): 2703-1233, 2703-124
Time-dependent metabolome and fatty acid profile changes following a high-fat diet exposure in Drosophila melanogaster
No full textHigh-fat diets (HFDs) are often used to study metabolic disorders using different animal models. However, the underlying cellular mechanisms pertaining to the concurrent loss of metabolic homeostasis characteristics of these disorders are still unclear mainly because the effects of such diets are also dependent on the time frame of the experiments. Here, we used the fruit fly, Drosophila melanogaster, to investigate the metabolic dynamic effects following 0, 2, 4, 7 and 9 days of an exposure to a HFD (standard diet supplemented with 20% w/v coconut oil, rich in 12:0 and 14:0) by combining NMR metabolomics and GC-FID fatty acid profiling. Our results show that after 2 days, the ingested 12:0 and 14:0 fatty acids are used for both lipogenesis and fatty acid oxidation. After 4 days, metabolites from several different pathways are highly modulated in response to the HFD, and an accumulation of 12:0 is also observed, suggesting that the balance of lipid, amino acid and carbohydrate metabolism is profoundly perturbed at this specific time point. Following a longer exposure to the HFD (and notably after 9 days), an accumulation of many metabolites is observed indicating a clear dysfunction of the metabolic system. Overall, our study highlights the relevance of the Drosophila model to study metabolic disorders and the importance of the duration of the exposure to a HFD to study the dynamics of the fundamental mechanisms that control metabolism following exposure to dietary fats. This knowledge is crucial to understand the development and progression of metabolic diseases.udemauteur: Jérémie Doiron; Mohamed Touaibia; Marc Surette; Nicolas Pichau
Caractérisation et modulation de la résistance au témozolomide chez le glioblastome multiforme
No full text"Le glioblastome multiforme (GBM) est la forme de tumeur cérébrale la plus commune et l'approche thérapeutique à ce jour implique une combinaison de chirurgie, radiothérapie et de la chimiothérapie avec le témozolomide (TMZ). De nombreux mécanismes contribuant à une résistance innée ou acquise à cet agent thérapeutique ont été identifiés et peuvent mener à un échec du traitement. Cette étude entreprend une approche métabolomique pour caractériser des profils métaboliques observés chez des cellules GMB sensibles ou résistantes au TMZ. Cette approche fut aussi utilisée pour explorer les changements métaboliques observés suite au traitement avec le TMZ et lomeguatrib, un inhibiteur de la MGMT avec un potentiel sensibilisateur au TMZ. Des métabolites ayant déjà été identifiés comme ayant des rôles dans la résistance à la chimiothérapie incluant le glucose, la citrate et l'isocitrate ont démontré des niveaux élevés chez les cellules résistantes au TMZ. De plus, une signature de métabolites comprenant l'alanine, la choline, la créatine et la choline phosphorylée a été identifiée comme élevée dans la lignée U373S suite à tous les traitements étudiés. Ces résultats présentent les profils métaboliques associés à la réponse au TMZ dans des modèles de lignées cellulaires GBM et proposent une suite intéressante qui pourrait influencer le développement d'outils thérapeutiques ou diagnostiques pouvant avoir un impact sur la réponse au TMZ ches les GBMs. Des analogues structuraux du lomeguatrib ont aussi été synthétisés afin de mieux comprendre le mécanisme d'inhibition et les paramètres structuraux nécessaires à une bonne inhibition de cette protéine. Malgré la variabilité de les GI₅₀ de ces molécules, trois d'entre elles semblent avoir un impact lors des traitements combinatoires avec le TMZ. Un groupement aromatique relié en position O6 par un groupement CH₂ et un groupement donneur semble être la meilleure combinaison pour l'inhibition de cette protéine et une viabilité cellulaire réduite."--Sommaire.statement of responsibility: Patrick-Denis St-Coeur, B.Sc.Thèse présentée à la Faculté des études supérieures et de la recherche en vue de l'obtentin de la maîtrise ès sciences en biochimie.thesis: B. Sc. (biochimie) Université de Moncton 2015bibliography: Comprend des références bibliographiques: feuilles 78-108.additional physical form: Également disponible en version électronique. Les pages contenant des informations personnelles ne sont pas reproduites.language: Thèse rédigée sous forme d'article, comprend du texte en français et en anglais
Entretien avec Mohamed Miloud Gharrafi
No full textMohamed Miloud Gharrafi, auteur de plusieurs recueils de poèmes en arabe, a signé, en 2014, une anthologie bilingue de ses poèmes autotraduits, augmentée d’inédits, intitulée Échos lointains. Il a accepté de s’entretenir avec nous sur sa pratique d’écrivain et de traducteur, et de présenter sa vision de l’acte de traduction et de ses relations avec la création, aussi bien dans le cas de l’autotraduction que dans celui de la traduction d’autres poètes, dont il a fait l’expérience à plusieurs reprises. Cette réflexion l’amène à poser la question des liens complexes, dans la poésie et sa traduction, entre la forme et le sens. Elle l’amène également à décrire son rapport, à la fois de filiation et de rupture, avec la tradition poétique arabe, ainsi que ses appartenances multiples à divers univers culturels et littéraires.Mohamed Miloud Gharrafi, author of several collections of poems in Arabic, signed a bilingual anthology of his self-translated poems in 2014, supplemented by unpublished ones, entitled Échos lointains. He has agreed to talk with us about his practice as a writer and translator, and to present his vision of the act of translation and its relationship with creation, both in the case of self-translation and in the case of the translation of other poets, which he has experienced on several occasions. This reflection leads him to question the complex links, in poetry and its translation, between form and meaning. It also leads him to describe his relationship, both of filiation and rupture, with the Arab poetic tradition, as well as his multiple affiliations to various cultural and literary worlds
Mohamed Enver Surty’s In Pursuit of Dignity
No full textIn Pursuit of Dignity is the unusual autobiography of our erstwhile Deputy Minister of Basic Education, Mohamed Enver Surty. The author served in government for twenty five years with distinction, and can be justly proud of a distinguished career both as a lawyer and as a government minister
Tradurre la bande dessinée migrante. Il caso de Les Mohamed di Jérôme Ruillier
No full textThe comic book Les Mohamed (2011) by French author Jérôme Ruillier is situated in the landscape of migrant bande dessinée, with its own singular characteristics. In this work, the author traced a global portrait of Maghrebi immigrants in France, by adapting the documentary/book Mémoires d’immigrés (1997) by French-Algerian author Yamina Benguigui. As migrant storytellers in general, bande dessinée authors are often the first ‘translators’ of unknown or removed realities, making them accessible to a large public. But what happen when they are translated in their turn? In a first part, this article canvases the process of intersemiotic translation that brought from Mémoires d’immigrés to Les Mohamed. In a second part, it focuses on the verbal/visual aspects of Ruillier’s work and especially on the solutions I adopted in the Italian translation (Se ti chiami Mohamed 2015)
Orality as Aesthetic Device: Articulating Language, Religion, and Authority in Mohamed Akounad’s Tawargit d Imik
No full textThis article explores Mohamed Akounad\u27s novel Tawargit d imik, which focuses on protagonist Ssi Brahim who struggles to convey the essence of his religious sermons to an exclusively amazigh audience amidst societal opposition. By examining Ssi Brahim\u27s character as the author\u27s alter ego, the study aims to assess the novel\u27s portrayal of religious concerns and activism for Tamazight and identity, particularly in relation to orality. Employing a sociolinguistic approach drawing from Bourdieu\u27s Language and Symbolic Power, the analysis delves into the intersection of religion, authority, and language, placing orality at the heart of their role within the narrative. This study proposes a dual analytical approach, comprising textual and transtextual analyses, in order to unravel the protagonist\u27s journey and explore intertextual connections with sacred texts.
Keywords: orality, intertextuality, language, linguistic capital, symbolic capital, Tamazight, religion, powe
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