69 research outputs found
The Dynamics of Dendritic Cell—Mediated Innate Immune Regulation
No full textABSTRACTAfter taking up pathogen-derived antigens, dendritic cells (DCs) leave peripheral organs and migrate into sentinel lymph nodes via afferent lymphatic vessels. During this process, they undergo maturation and produce proinflammatory cytokines, which leads to efficient antigen (Ag) presentation and activation of the innate and acquired immune systems. Recent evidence indicates that DC subsets cooperate to activate the innate immune system. It is becoming clear that the total DC population is composed of a network of DC subsets with distinct functions that are critical for sensing pathogens and orchestrating immune responses
IL-15-dependent cross-talk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation
No full textapplication/pdfUnmethylated CpG oligodeoxynucleotides （CpG） prevalent in bacteria and DNA viruses bind Toll-like
receptor（ TLR） 9 and directly stimulate DCs, thereby activating the innate and adaptive immune responses. CpG is
potentially a powerful reagent for protective immunity against infection by a wide variety of pathogens, for cancer
and allergy therapies, and for the development of prophylactic and therapeutic vaccines. Here we investigated the
role of interleukin （IL）-15 in the activation of CpG-induced immune responses. We show that upon CpG-priming,
both wild-type（ WT） and NK cell-depleted WT mice produce interleukin（ IL）-12 p70 and become resistant to a lethal
dose of Listeria monocytogenes（ LM）, whereas IL-15-/- mice impair IL-12 p70 production and succumb to the infection.
Notably, CpG-stimulated conventional dendritic cells （cDCs） are the major producer of both IL-15 and IL-12 p70,
but cDCs do not produce IL-12 in the absence of plasmacytoid DCs（ pDCs） in vivo. Importantly, cDC-derived IL-15
induces CD40 expression on cDCs, which interacts with CD40 ligand on pDCs, leading to CD40 cross-linking and IL-12
production. Collectively, these fi ndings show that IL-15-dependent cross-talk between cDCs and pDCs is essential for
CpG-induced immune activation（ recently published in Nat Immunol 2006;7:740-6）弘前医学. 59(Suppl.), 2007, p.S35-S4
Bipotent or Oligopotent? A Macrophage and DC Progenitor Revisited
No full textMacrophage and dendritic cell (DC) progenitors (MDPs) produce macrophages and DCs but not other hematopoietic lineages. In this issue of Immunity, Sathe et al. (2014) show that isolated MDP populations hardly contain such bipotent progenitors at clonal levels, arguing against the existence of MDPs
Regulatory mechanism of host defense by interleukin-15
No full textAlthough some functional activities of interleukin (IL) -15 on NK and T cells overlap with those of IL-2, recent findings obtained from gene-targeted mice deficient in components of IL-2/IL-15 system demonstrate distinct roles of IL-15 for the activation of innate as well as acquired immune system. IL-15 is a pivotal cytokine for the development and survival of NK cells, NKT cells, TCRyu+ intestinal intraepithelial lymphocytes (iIEL), and for the functional maturation of dendritic cells and macrophages. IL-15 is also important for memory T cell maintenance in vivo. In this review, I summarize recent progress of studies in the IL-15/IL-15R system
Overexpression of Bcl-2 Differentially Restores Development of Thymus-Derived CD4−8+ T Cells and Intestinal Intraepithelial T Cells in IFN-Regulatory Factor-1-Deficient Mice
No full textインターロイキン-15による生体防御調節機構
No full textAlthough some functional activities of interleukin (IL) -15 on NK and T cells overlap with those of IL-2, recent findings obtained from gene-targeted mice deficient in components of IL-2/IL-15 system demonstrate distinct roles of IL-15 for the activation of innate as well as acquired immune system. IL-15 is a pivotal cytokine for the development and survival of NK cells, NKT cells, TCRyu+ intestinal intraepithelial lymphocytes (iIEL), and for the functional maturation of dendritic cells and macrophages. IL-15 is also important for memory T cell maintenance in vivo. In this review, I summarize recent progress of studies in the IL-15/IL-15R system
- …
