198,136 research outputs found

    Serum microRNAs as biomarkers of human lymphocyte activation in health and disease

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    Induction of the adaptive immune system is evaluated mostly by assessment of serum antibody titers and T lymphocyte responses in peripheral blood, although T and B cell activation occurs in lymphoid tissues. In recent years, the release of microRNAs (miRNAs) in the extra-cellular environment has been exploited to assess cell functions at distance via measurement of serum miRNAs. Activated lymphocytes release a large amount of nano-sized vesicles (exosomes), containing miRNA, however there are insufficient data to determine whether this phenomenon is reflected in modulation of serum miRNAs. Interestingly, miRNA signatures of CD4+ T cell-derived exosomes are substantially different from intracellular miRNA signatures of the same cells. We have recently identified serum circulating miR-150 as a sensor of general lymphocyte activation and we strongly believe that miRNAs differentially released by specific CD4+ effector T cell subsets (Th1, Th2, Th17, and Treg) may serve as serum biomarkers of their elicitation in lymphoid tissues but also in damaged tissues, potentially providing clinically relevant information about the nature of immune responses in health and disease. © 2014 de Candia, Torri, Pagani and Abrignani

    The Pollen Reference Collection of LPP – UNIMORE

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    The Pollen Reference Collection of the Laboratory of Palynology and Palaeobotany (LPP) of the University of Modena and Reggio Emilia is titled to Daria Bertolani Marchetti who carried out to Modena the first slides in 1989. The Reference Collection is organized in the following sections: 1) Envelopes, with pollen from plant material collected in the field or from herbarium sheets, are 3098, and refer to about 1100 different species. 2) Microtubes, contain acetolysed pollen preserved in glycerol jelly, and are about 1440. 3) Slides are mounted with acetolysed and fresh pollen. Therefore, the pollen collection can be used for paleopalynology and actuopalynology. The slides, put into boxes slide rack, are classified according to the morphological criterion (NPC = Number - Position - Character of the apertures - Erdtman, 1969). Their number is about 2000. In the Reference Collection there are three sections: Reference Collection, containing the reference material, described above; Research Collection, relating to materials and sites studied in the laboratory (ca. 22,000 slides); Educational Collection, containing two types of reference slides: slides with the pollen of a single species and “mixed slides” with more species with the same aperture type, number and position, set up to facilitate the distinction of similar pollen. The Educational Collection includes selected slides with material from research work, e.g. archaeological sites, lake/fluvial sediments, forensic cases, honeys, plant systematics. The use of the collection has been recently improved by a database designated by F. Torri and P. Torri, to search the reference material by taxonomic criteria and/or morphological characteristics. Users can search the database according to a single criterion or a combination of morphological characteristics commonly used to visually identify pollen: aperture, exine ornamentation, size range. Images of the pollen will be associated to relevant species

    It-torri ta' l-arloġġ tal-Birgu

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    It-Torri tal-Birgu kien imwaqqaf mill-Gran Mastru Ġwann D’Omedes fl-1549. Dan it-torri ġie mibni biex iservi ta’ turretta u jkunu jistgħu jaraw ix-xwieni li jitfaċċaw. B’qanpiena jew b’bandiera, il-Kavallieri kienu jifhmu li ġej xi attakk.N/

    Lit-torri ta’ Londra

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    Ġabra ta’ poeżiji u proża li tinkludi: Poeżiji ta’ Albert M. Cassola – Ferrovija – Xita – Belt – Ħajja ċassa – Xmara sewda – Konsa ta’ mgħallem Indrì ta’ F. X. Mangion – Jogħġob iż-żgħir ta’ Amante Buontempo – Milied 197.... ta’ Alfred Massa – Il-ballata tad-disgħa u wieħed ta’ J. P. Vassallo – Xwejjaħ ta’ Trevor Zahra – Meta twelidt... ta’ Pawlu Mifsud – Jekk.... iżda.... ta’ Frans Baldacchino – Lit-torri ta’ Londra ta’ Joseph Sciberras.peer-reviewe

    BRAIN id: NTR40– pollen dataset

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    Gardolo (Trento, N Italy). Dataset including pollen counts from sediment samples collected from the archaeological site of Gardolo (Trento; 46°06'55.3" N, 11°06'58.43" E; 360 m a.s.l.; chronology: from ca. 2550 to ca. 1150 BC ). The dataset was created as part of the National Biodiversity Future Center (NBFC, Palermo, Italy). The site is included in the BRAIN database (https://brainplants.successoterra.net/; site id: NTR40)

    Effetti del creep sulla stabilità delle torri

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    Molte torri antiche sono afflitte da problemi di stabilità. Le fondazioni di tali strutture sono generalmente superficiali ed è tramite i modelli basati sul macroelemento, sviluppati per tali fondazioni, che è possibile studiare i due meccanismi di collasso, tipici delle fondazioni delle torri: la capacità portante e la stabilità dell’equilibrio. Per le torri storiche particolarmente importanti sono i fenomeni di creep, che regolano l’evoluzione nel tempo delle rotazioni dell’asse di queste strutture. Gli autori propongono in questo studio una metodologia per implementare il creep nella formulazione del macroelemento con un approccio di tipo semiempirico. Da tali sviluppi derivano importanti considerazioni sulle previsioni del collasso della struttura per instabilità dell’equilibrio. La formulazione è dimostrata in relazione alla torre di Pisa
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