1,721,018 research outputs found
Silk-based Drug Delivery Systems
No full textSilk proteins show excellent biocompatibility, controllable biodegradability and non-immunogenicity, and as such are studied extensively worldwide for biomedical applications. In particular, there is increasing interest in their use for drug delivery systems. This focussed book on silk proteins for drug delivery systems, delves into a key emerging area to outline the concepts and define the field.
Covering spider silk and silk worm cocoons, the editors elucidate the extraction, structure and properties of silk sericin and silk fibroin. Showing how these proteins are employed in micro and nano drug delivery systems, their use in pre-clinical and clinical trials, and closing with chapter on sustainability- driven innovation in the pharma industry, this book is ideal for graduates and researchers in biomaterials science and pharmaceutical science
From mesenchymal stem/stromal cells to cell products: pharmaceutical development of secretome as new biological medicinal product
No full textScaffold for tissue regeneration, particularly for bone regeneration, and manufacturing method thereof.
No full textMesenchymal stem/stromal cell secretome for lung regeneration: The long way through “pharmaceuticalization” for the best formulation.
No full textPulmonary acute and chronic diseases, such as chronic obstructive pulmonary disease, pulmonary fibrosis and pulmonary hypertension, are considered to be major health issues worldwide. Cellular therapies with Mesenchymal Stem Cells (MSCs) offer a new therapeutic approach for chronic and acute lung diseases related to their anti-inflammatory, immunomodulatory, regenerative, pro-angiogenic and anti-fibrotic properties. Such therapeutic effects can be attributed to MSC-secretome, made of free soluble proteins and extracellular vesicles (EVs). This review summarizes the recent findings related to the efficacy and safety of MSC-derived products in pre-clinical models of lung diseases, pointing out the biologically active substances contained into MSC-secretome and their mechanisms involved in tissue regeneration. A perspective view is then provided about the missing steps required for the secretome “pharmaceuticalization” into a high quality, safe and effective medicinal product, as well as the formulation strategies required for EV non-invasive route of administration, such as inhalation
From mesenchymal stem/stromal cells to cell products: pharmaceutical evelompment of secretome as new biological medicinal product
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Scaffold for tissue regeneration, particularly for bone regeneration, and manufacturing method thereof.
No full textOsteoinductive and osteoconductive properties of 3D Printed scaffolds containing Mesenchymal Stem/Stromal Lyosecretome
No full textOsteoinductive and osteoconductive properties of Biohybrid Bovine Bone Matrix containing Mesenchymal Stem/Stromal Cell Lyosecretome
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