560 research outputs found
Vitronectin: growth factor complexes hold potential as a wound therapy approach
No full textTopical administration of growth factors has displayed some potential in wound healing, but variable efficacy, high doses, and costs have hampered their implementation. Moreover, this approach ignores the fact that wound repair is driven by interactions between multiple growth factors and extracellular matrix (ECM) proteins. We report herein that complexes comprising IGF and IGF-binding proteins bound to the ECM protein vitronectin (VN) significantly enhance cellular functions relevant to wound repair in human skin keratinocytes in two- and three-dimensional in vitro cell models and are active, even in the presence of wound fluid. Moreover, these responses require activation of both the IGF receptor and the VN-binding av integrins. Further, we assessed the complexes as a topical agent in the treatment of deep dermal partial thickness burns in a porcine model. This pilot study revealed that the complexes may hold promise as a wound healing therapy. Critically, the significant responses observed in vitro and the encouraging preliminary data in vivo were obtained with nanogram doses of growth factors. This suggests that coupling delivery of growth factors to ECM proteins such as VN may ultimately prove to be a more effective strategy for developing a wound healing therapy.Zee Upton, Leila Cuttle, Anthony Noble, Margit Kempf, Gemma Topping, Jos Malda, Yan Xie, Julie Mill, Damien G Harkin, Olena Kravchuk, David I Leavesley and Roy M Kimbl
Development of defined media for the serum-free expansion of primary keratinocytes and human embryonic stem cells
No full textWhat does the word ‘Europe’ make you think of? Conceptualisations of Europe in a local context
No full textThe present article investigates the construction of the sense of belonging toward Europe in the public sphere, employing a case-study conducted in Italy. The author argues that different conceptualisations of Europe are related to diverse “uses” of the media, familiarity with international cultural resources and participation in the transnational public sphere and civil society. These variables affect the construction of Europeans' sense of belonging
Correction: Yagüe, P., et al. Goals and Challenges in Bacterial Phosphoproteomics. Int. J. Mol. Sci. 2019, 20, 5678
No full textThe authors wish to make the following corrections to this paper [1]:The author name “Gemma Fernánez-García” should be “Gemma Fernández-García” [...
Petrarca e Osberno di Gloucester
No full textSi presenta l'edizione commentata delle note autografe di Petrarca contenute nel Par. Lat. 7492, testimonianza della lettura e dell’utilizzo delle Derivationes di Osberno di Gloucester, altrimenti mai esplicitamente menzionate altrove da Petrarca (il titolo e l’autore rimasero a lungo ignoti). In esse Petrarca indica accordi e discordanze con le Derivationes di Uguccione da Pisa.It presents the annotated edition of Petrarch's autograph notes contained in Para Lat. 7492, evidence of reading and the use of Derivationes Osberno of Gloucester, otherwise never explicitly mentioned elsewhere by Petrarch (the title and the author remained unknown for a long time). In them Petrarca indicates agreements and disagreements with the Derivationes of Huguccio
Le opere storiche di Antonio Ivani da Sarzana
No full textSi forniscono alcune osservazioni e contributi al volume Antonio Ivani da Sarzana, 'Opere storiche' in cui sono pubblicate le principali opere storiche di questo illustre umanista, scrittore prolifico impegnato attivamente nella vita civile e politica del tempo. Interessanti spunti di riflessione offre la tradizione manoscritta, in particolare per la presenza di numerosi autografi rivisti dall’autore.We provide some comments and contributions to the volume Antonio Ivani from Sarzana, 'Historical works' which are published in major historical works of this illustrious humanist, prolific writer actively involved in civic and political life of the time. Offers interesting insights into the manuscript tradition, in particular the presence of numerous autographs revised by the author
R v Evans (Gemma) [2009] EWCA Crim 650, Court of Appeal
No full textEssential Cases: Criminal Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in R v Evans (Gemma) [2009] EWCA Crim 650, Court of Appeal. The document also included supporting commentary from author Jonathan Herring.</p
What is the role of an interdisciplinary researcher?
No full text© The Author 2007; all rights reserved.James A Smith and Gemma E Care
STRANIERO E DEVIANZA IN ITALIA
No full textIl lavoro esamina la “questione immigrazione”, che ha assunto in Italia rilevanza crescente soprattutto per l’insorgere di conflittualità, provocando spesso sentimenti di insicurezza e una falsa percezione dell’immigrato come deviante, anche per effetto della rappresentazione mediatica. L’autore si propone di disegnare, attraverso i dati statistici ufficiali dal 2001, un quadro quantitativo e qualitativo dell’immigrazione irregolare e clandestina, nonché della criminalità degli stranieri, alla luce dei mutamenti delle politiche migratorie europee e italiane.This paper examines the "immigration issue", which has taken in recent years increasing importance in Italy, especially for the uprising of social conflicts, often because of the feelings of insecurity and a false perception of immigrants as deviant, partly as a outcome of media representation. The author outlines, through the analysis of official statistics since 2001, the quantitative/qualitative scenario of irregular and illegal migration and aliens' criminality according to the changes of European and Italian politics of migration control
Gemma King, Jacques Audiard, Manchester: Manchester University Press, 2021
No full textAs the director of nine feature films, author of at least two dozen screenplays, and the recipient of a Grand Prix and Palme d’Or at Cannes, multiple Césars, and a myriad of international awards, Jacques Audiard merits a book. Surprisingly, Gemma King’s is the first, in English or in French. Although her focus is on the features, from See How They Fall/Regarde les hommes tomber (1994) through The Sisters Brothers/Les frères Sisters (2018), King is concerned with Audiard’s body of work as a w..
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