111,909 research outputs found
Francesco V. Tomassi (comp.) : Der Zyklop in der Wissenschaft. Kant und die anthopologia transcendentalis, Archiv für Begriffsgeschichte, 14, Hamburg: Félix Meiner Verlag, 2018
No full textReseña de: Francesco V. Tomassi (comp.), Der Zyklop in der Wissenschaft. Kant und die anthopologia transcendentalis, Archiv für Begriffsgeschichte, 14, Hamburg, Félix Meiner Verlag, 2018, 207 pp. ISBN: 978-3-7873-3427-8
Strumenti per il raggiungimento delle coperture vaccinali, verifica della qualità delle prestazioni e valutazione dei programmi vaccinali
No full textOpportunità di uno “screening” perimetrico negli addetti alla guida di mezzi ad alta velocità.
No full textPossibilità di uno screening perimetrico per gli addetti alla guida di mezzi ad alta velocità.
No full textauthor-bios-SRD-19-0063.R1 – Supplemental material for The Network Structure of Police Misconduct
No full textSupplemental material, author-bios-SRD-19-0063.R1 for The Network Structure of Police Misconduct by George Wood, Daria Roithmayr and Andrew V. Papachristos in Socius</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Strumenti per il raggiungimento delle coperture vaccinali, verifica della qualità delle prestazioni e valutazione dei programmi vaccinali
No full textBDNF transcripts modulation in the blood of subjects exposed to childhood trauma history
No full textAdverse influences, particularly early in development, can result in permanent changes in physiology and metabolism, which result in increased disease risk in adulthood. Childhood trauma experiences have been indeed found able to modulate brain structure and functions through alterations in neuroplasticity [1].
Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin that plays a crucial role in neuronal development and plasticity; it is involved in the effects of stress and also in the pathogenesis of several mental disorders. The human BDNF gene is very complex and it consists of several transcripts that are all characterized by the presence of the common coding exon at the 3’end [2,3].
To date no information regarding the expression of BDNF transcripts in the blood and of their possible modulation by stressful experiences is available.
The aim of this study was to characterize the expression of BDNF transcripts in the blood of human subjects and investigate their modulation in association to exposure to stressful life experiences.
We have measured total BDNF mRNA levels through Real Time PCR in peripheral blood of adult subjects (n=40) clinically assessed for exposure during childhood to sexual, emotional and/or physical trauma by childhood trauma questionnaire. We found a significant reduction in the mRNA levels of total BDNF in the blood of subjects exposed to childhood trauma versus not exposed subjects (p<0.05, −32%).
Then, to identify the BDNF transcript able to contribute to this BDNF modulation, we assessed the expression levels of the different BDNF transcript in the blood and we found that only transcripts IV and IX were well expressed. Thus, we focused our subsequent analyses on these transcripts and we evaluated by Real Time PCR their modulation in association with childhood trauma events. We found a significant modulation of both the transcripts, although a more pronounced effect was observed for transcript IV (−71%, p<0.05 for transcript IV; −35%, p<0.05 for transcript IX).
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In order to better characterize BDNF variants modulation we measured the levels of total BDNF and of the transcript IV and IX in an in vitro model represented by human hippocampal progenitors stem cells (HPSc) that we treated for three days during proliferation phase. Gene expression analyses were performed after 10 days of differentiation. We found that BDNF total levels and transcript IV and IX were downregulated also in HPC treated with cortisol (total BDNF −25%, p<0.05; transcript IV −19%, p<0.05; transcript IX −27%, p<0.05).
In order to investigate the molecular mechanisms underlying these long lasting changes in BDNF we are evaluating the role of DNA methylation and miRNAs as possible epigenetic mechanisms.
These data indicate that BDNF levels are reduced in the peripheral blood of subjects exposed to childhood trauma and that similar modulation occurs in neurons. BDNF variants IV and IX are the transcripts that contribute to BDNF modulation and a better characterization of their modulation may identify novel target for preventative therapies in subjects exposed to trauma and thus at higher risk to develop psychiatric illnesses in adulthood
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