1,721,093 research outputs found
Pedagogical strategies for family business members from a lifelong learning perspective
No full textThis chapter aims at contributing to the literature on education for business families shedding light on some current knowledge gaps, new research directions, and future contributions. We have focused on highlighting the elements that make family business education a promising field for developing lifelong, multigenerational pedagogical strategies, becoming a field of experimentation that could be beneficial for the innovation in multidisciplinary university education. We have also explored the characteristics of various teaching methods that are new for family business education at universities, and how they relate with the different types of learning categorized by Le Breton-Miller and Miller (2015). Since education to business families is an area that is on its nascent stage, a high research potential is placed ahead
Family Business Research: 5th Wave Perspectives
No full textMore than three decades support the research on the family business. The
progress achieved, beyond the disagreements, is considerable. However,
significant changes in the macro and microenvironment, and their influence
on the companies lead to rethinking new perspectives. This new research
agenda is multidimensional to achieve a deeper understanding of the essence
of the family business. The objective is to find axes that allow hold up the
family business to overcome new challenges. Renowned authors from all
over the world have reflected on this and offered us new and high-quality
perspectives to enrich debate and promote research
Boards of directors in italian family businesses
No full textThis paper presents some of the early results of an international research project conducted in Italy and coordinated by Prof. Miguel Angel Gallo. The research project involved Spain, Portugal, Italy, Brazil, Argentina, and the U.S. The authors of this paper are responsible for the Italian part of the project. The project aims to further the understanding of the role of the board of directors in family businesses, and how the board functions
AKT-dependent phosphorylation of the adenosine deaminases ADAR-1 and -2 inhibits deaminase activity
No full textMurine thymoma viral oncogene homolog (AKT) kinases target both cytosolic and nuclear substrates for phosphorylation. Whereas the cytosolic substrates are known to be closely associated with the regulation of apoptosis and autophagy or metabolism and protein synthesis, the nuclear substrates are, for the most part, poorly understood. To better define the role of nuclear AKT, potential AKT substrates were isolated from the nuclear lysates of leukemic cell lines using a phosphorylated AKT substrate antibody and identified in tandem mass spectrometry. Among the proteins identified was adenosine deaminase acting on RNA (ADAR)1p110, the predominant nuclear isoform of the adenosine deaminase acting on double-stranded RNA. Coimmunoprecipitation studies and in vitro kinase assays revealed that AKT-1, -2, and -3 interact with both ADAR1p110 and ADAR2 and phosphorylate these RNA editases. Using site-directed mutagenesis of suspected AKT phosphorylation sites, AKT was found to primarily phosphorylate ADAR1p110 and ADAR2 on T738 and T553, respectively, and overexpression of the phosphomimic mutants ADAR1p110 (T738D) and ADAR2 (T553D) resulted in a 50-100% reduction in editase activity. Thus, activation of AKT has a direct and major impact on RNA editing.-Bavelloni, A., Focaccia, E., Piazzi, M., Raffini, M., Cesarini, V., Tomaselli, S., Orsini, A., Ratti, S., Faenza, I., Cocco, L., Gallo, A., Blalock, W. L. AKT-dependent phosphorylation of the adenosine deaminases ADAR-1 and -2 inhibits deaminase activity
Family business debates: Multidimensional perspectives across countries, continents and geo-political frontiers
No full textFamily Business Debates provides a novel, ground-breaking approach to diverse and contemporary topics in current business management research, focusing on family enterprises to study both the positive and negative aspects of such commercial structures.
In Family Business Debates: Multidimensional Perspectives Across Countries, Continents and Geo-political Frontiers the authors propose an exploratory journey in 18 stages towards one of the founding territories, and paradoxically less studied, of our economic system, the family business. The interaction of two complex systems, such as family and business, is addressed in this very interesting book, which first analyzes this confluence from a philosophical and sociological perspective and then illustrates the development of this business model in various geographies. The result? An essential text for those who want to understand the dynamics of family business, either for academic purposes or as support for their professional practice.
– Alejandro Javier Rosa, Partner in PwC Argentin
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
ADARs and the balance game between virus infection and innate immune cell response
No full textAll viruses that have dsRNA structures at any stages of their life cycle may potentially undergo RNA editing events mediated by ADAR enzymes. Indeed, an increasing number of studies that describe A-to-I sequence changes in viral genomes and/or transcripts, consistent with ADAR deaminase activity, has been reported so far. These modifications can appear as either hyperediting or specific RNA editing events in viral dsRNAs. It is now well established that ADAR enzymes can affect viral life cycles in an editing-dependent and -independent manner, with ADARs acting as pro- or antiviral factors. Despite the discovery of editing events in viral RNAs dates back to thirty years ago, the biological consequences of A-to-I changes during viral infection is still far to be completely elucidated. In this review, past and recent studies on the importance of ADAR enzymes on several viruses will be examined
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