1,720,975 research outputs found
Idiopathic focal organizing pneumonia mimicking malignancy
No full textWOS: 000572821900001PubMed ID: 33014252Idiopathic FOP is a rare type of COP. What we know on this subject is made up of a few clinical cases published in recent years. Our patient was admitted to the hospital with an intermittent coughing complaint that worsens over time. Due to a suspicion of malignancy, a radiological evaluation was requested including a PET-CT and a transbronchial biopsy was performed. Until the last part of our algorithm, the patient profile was clinically and radiologically in favor of the diagnosis of malignancy but, in the end, the diagnosis of FOP was fixed with a follow-up decision. In conclusion, FOP is a relatively new entity that should be kept in mind in the differential diagnosis of malignancy
Changes in olfactory bulbus volume and olfactory sulcus depth in the chronic period after COVID-19 infection
No full textBackground: Although there are a limited number of studies investigating the changes in olfactory bulb volume (OBV) and olfactory sulcus depth (OSD) values in the acute and subacute periods after COVID-19 infection, there are no studies conducted in the chronic period.
Purpose: The aim of this study is to reveal the changes in OBV and OSD after COVID-19 in the chronic period.
Material and methods: A total of 83 people were included in our study, including 42 normal healthy individuals (control group) and 41 patients with COVID-19 infection (10-12 months after infection).
Results: The COVID-19 group included 41 patients with the mean age 40.27 ± 14.5 years and the control group included 42 individuals with the mean age 40.27 ± 14.4. The mean OBV was 67.97 ± 14.27 mm3 in the COVID-19 group and 94.21 ± 7.56 mm3 in the control group. The mean OSD was 7.98 ± 0.37 mm in the COVID-19 group and 8.82 ± 0.74 mm in the control group. Left, right, and mean OBVs and OSD were significantly lower in patients with COVID- 19 than the control individuals (all p < .05).
Conclusion: Our findings show that COVID-19 infection causes a significant decrease in the OBV and OSD measurements in the chronic period
Association of Vitamin D and Secondary Infection in COVID-19
No full textGiriş: D vitamini sitokin salınımı, inflamasyon, doğal ve edinsel bağışıklığın modülasyonunda görev yapmaktadır. Pandeminin başların- da SARS-CoV-2’ye bağlı gelişen akut respiratuvar distres sendromu veya diğer organ hasarına neden olan hiperinflamatuvar yanıtın D vitamininin yeterliliği ile modüle edilebileceği sıkça tartışılmıştır. D vitamininin; mortalite, yoğun bakım yatış gün sayısı, hastalık ciddiye-ti, organ hasarı gibi birçok durum ile de ilişkisi araştırılmıştır fakat hastalığın seyri sırasında ortaya çıkan sekonder infeksiyonlar üzerine etkisi konusunda bilgiler sınırlıdır. Bu çalışmada D vitamininin COVID-19 hastalığı seyri sırasında ortaya çıkan sekonder infeksiyonlar ile ilişkisini ortaya koymak amaçlanmıştır.
Materyal ve Metod: COVID-19 pandemi servisine COVID-19 tanısı ile yatarak tedavi gören hastaların tıbbi kayıtları retrospektif olarak değerlendirildi.
Bulgular: Çalışmaya 181 hasta dahil edildi. 25(OH)D vitamini ortalaması 18.76 ± 9.82 ng/mL olarak bulundu. 25-hidroksi D vita-minin cinsiyet, hastalık şiddeti, mortalite, mekanik ventilasyon ihtiyacı ve semptomların varlığı ile karşılaştırıldığında istatistiksel olarak anlamlı bir fark saptanmadı (p> 0.05). Hastaların hastane yatışları boyunca olan tıbbi verileri incelendi ve %14.9’unda (n= 27) sekonder infeksiyon saptandı. 25-hidroksi D vitamini ile sekonder infeksiyon varlığı karşılaştırıldığında ise sekonder infeksiyon gelişenlerin 25(OH)D vitamini düzeyi düşük bulundu ve bunun istatistiksel olarak anlamlı olduğu tespit edildi (p= 0.016). ROC analizi ile yapılan değerlendirme sonucunda 25-hidroksi D vitamininin COVID-19 hastalarında pozitif kültür sonucunu öngörmede tanısal değeri olduğu görüldü (AUC= 0.771, %95 Güven aralığı= 0.612-0.810, p= 0.003, p< 0.05).
Sonuç: D vitamini immün sistem üzerindeki etkileri nedeniyle COVID-19 hastalığında önemli bir tartışma konusu olmaya devam ederken, düşük D vitaminin COVID-19 seyrinde gelişen sekonder infeksiyon riskini arttırdığı ve bu durumun prognoza etkisinin olabileceği unutulmamalıdır.Introduction: Vitamin D plays a role in the modulation of cytokine release, inflammation, innate and adaptive immunity. It has been frequently discussed that the hyperinflammatory response that causes acute respiratory distress syndrome or other organ damage due to SARS-CoV-2 at the beginning of the pandemic can be modulated by the adequacy of vitamin D. The relationship of vitamin D with many conditions such as mortality, number of intensive care unit stays, disease severity, and organ damage has been investigated, but the information on its effect on secondary infections that occur during the course of the disease is limited. In this study, it was aimed to reveal the relationship of vitamin D with secondary infections that occur during the course of COVID-19 disease.
Materials and Methods: Medical records of patients hospitalized in the COVID-19 pandemic service with the diagnosis of COVID-19 were evaluated retrospectively.
Results: One hundred eighty-one patients were included in the study. The mean of 25(OH) vitamin D was found to be 18.76 +/- 9.82 ng/mL. When 25-hydroxy vitamin D was compared with gender, disease severity, mortality, need for mechanical ventilation and presence of symptoms, no statistically significant difference was found (p> 0.05). The medical data of the patients during their hospitalization were analyzed and secondary infection was detected in 14.9% (n= 27). When 25-hydroxy vitamin D and the presence of secondary infection were compared, the 25(OH)D vitamin level of those with secondary infection was found to be low and this was found to be statistically significant (p= 0.016). As a result of the evaluation made by ROC analysis, 25-hydroxy vitamin D was found to have a diagnostic value in predicting positive culture results in COVID-19 patients (AUC= 0.771, 95% Confidence Interval= 0.612-0.810, p= 0.003, p< 0.05).
Conclusion: While vitamin D continues to be an important topic of discussion in COVID-19 disease due to its effects on the immune system, it should not be forgotten that low vitamin D increases the risk of secondary infection developing in the course of COVID-19 and this may have an impact on prognosis
Spinal kord yaralanması olan hastalarda gelişen üriner sistem infeksiyonu sıklığı, etken dağılımı ve risk faktörlerinin belirlenmesi
No full textSpinal kord yaralanması olan hastalarda görülen tıbbi sorunların basında üriner
sistem infeksiyonları gelmektedir. Çalısmamızda spinal kord yaralanması olan hastalarda
görülen üriner sistem infeksiyonlarının sıklığının, etken dağılımının ve risk faktörlerinin
belirlenmesi amaçlanmıstır.
Çalısmaya 15 Subat 2008 ile 30 Haziran 2009 tarihleri arasında Baskent
Üniversitesi Ayas Rehabilitasyon Hastanesi’nde ve Ankara Fizik Tedavi ve Rehabilitasyon
Merkezi’nde takip edilen 18-65 yas arasındaki toplam 93 hasta dahil edilerek prospektif
olarak izlendi. Hastaların 78’i (%83.9) erkek ve 15’i (%15.1) kadın idi. Spinal kord
yaralanmasının en sık nedeni trafik kazası olarak belirlendi.
Takip edilen 93 hastanın 63’ünde (%67.7) asemptomatik bakteriüri, 21’inde
(%22.6) semptomatik üriner sistem infeksiyonu saptandı. Dokuz (%9.7) hastanın yatısı
süresince yapılan takiplerinde alınan idrar kültüründe üreme olmadı. Asemptomatik
bakteriüri tanısı ile izlenen 63 hastanın mesane bosaltım yolu 34’ünde (%53.9) kalıcı
sonda, 20’sinde (%31.7) temiz aralıklı kateterizasyon, 9’unda (%14.4) spontan idrar yapma
seklinde idi. Semptomatik üriner sistem infeksiyonu ile izlenen 21 hastanın 17’sinde
(%80.9) kalıcı sonda, 4’ünde (%19.1) temiz aralıklı kateterizasyon yöntemiyle mesane
bosaltımı sağlanıyordu. Semptomatik ÜSĐ ile izlenen hastalar arasında idrarını spontan
yapan yoktu. Üremesi olmayan 9 hastanın 6’sı (%66.7) kalıcı sonda ile izlenirken, 3’ü
(%33.3) idrarını spontan olarak yapmaktaydi. Kateterizasyon türü ile asemptomatik
bakteriüri veya semptomatik üriner sistem infeksiyonu gelismesi arasında istatistiksel
olarak anlamlı bir iliski saptanmadı. Takip süresince toplam 30 sistemik infeksiyon atağı
tespit edildi. Bu atakların 24’ü semptomatik üriner sistem infeksiyonu idi. Bakteriürisi olan
hastalardan izole edilen toplam 305 etkenin %49.9’u E.coli, %19.7’si Klebsiella spp.,
%8.2’si Enterococcus spp. olarak belirlendi. E.coli ve Klebsiella spp. suslarında kinolona
direnç oranı %56.8, trimetoprim sulfametoksazole direnç oranı %61.3 idi. Çok ilaca
dirençlilik oranı asemptomatik bakteriüri ataklarından izole edilen etkenlerde %48 ve
semptomatik üriner sistem infeksiyonu ataklarından izole edilen etkenlerde %66.6 olarak
saptandı. Semptomatik üriner sistem infeksiyonu gelisimi yönünden saptanan tek bağımsız
risk faktörü üriner kateterizasyon idi.
Spinal kord yaralanması olan hastalarda gelisen üriner sistem infeksiyonlarının
tedavisi planlanırken etkenlerde giderek artan direnç oranları göz önünde
bulundurulmalıdır
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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