3 research outputs found
Dentoskeletal Changes of Skeletal Class III Malocclusion with Severe Facial Asymmetry after Orthognathic Surgery: Case Report
No full textCraniofacial asymmetry is expressed as the difference in size between two parts of the face. It is originated by a discrepancy in size and position between the cranial base and the maxilla, between the cranial base and the mandible, or between the maxilla and the mandible. When the craniofacial asymmetry is severe and the patient has completed growth, the indicated treatment is performed in conjunction with orthodontics and orthognathic surgery, traditional approach or surgery first approach. A 24 year-old woman had chief complaints of mandibular protrusion and facial asymmetry. Extraoral examination indicated mandibular deviation to the right side, severe facial asymmetry, and a concave profile. Orthognathic surgical treatment plan was Lefort I osteotomy and two-piece maxillary osteotomy to correct the posterior crossbite. Concomitant surgical procedure for the mandible was bilateral sagittal split osteotomy to correct facial asymmetry and mandibular protrusion. After orthognathic surgery followed by postsurgical orthodontic treatment reveals skeletal Class I and acceptable facial aesthetics with Class I occlusion. According to this case report, double jaw surgical procedure including maxillary and mandibular movements is indicated for the treatment of severe facial asymmetry and skeletal Class III malocclusion
Development of Basic Concept and Algorithm for Myanmar Population Dataset Management System
No full textGenomic epidemiology of artemisinin resistant malaria
No full textAbstract: The current epidemic of artemisinin resistant Plasmodium falciparum in Southeast Asia is the result of a soft selective sweep involving at least 20 independent kelch13 mutations. In a large global survey, we find that kelchl3 mutations which cause resistance in Southeast Asia are present at low frequency in Africa. We show that African kelch13 mutations have originated locally, and that kelch13 shows a normal variation pattern relative to other genes in Africa, whereas in Southeast Asia there is a great excess of non-synonymous mutations, many of which cause radical amino-acid changes. Thus, kelch13 is not currently undergoing strong selection in Africa, despite a deep reservoir of variations that could potentially allow resistance to emerge rapidly. The practical implications are that public health surveillance for artemisinin resistance should not rely on kelchl3 data alone, and interventions to prevent resistance must account for local evolutionary conditions, shown by genomic epidemiology to differ greatly between geographical regions
