67 research outputs found
Whoever tramples the breadcrumbs will go blind: Cultural norms regarding feeding children and eating in Bulgarian society. A conversation between Petya Bankova and Vihra Baeva
Get PDFPetya Bankova is Associated Professor in the Institute of Ethnology and Folklore Studies with Ethnographic Museum at the Bulgarian Academy of Sciences (Sofia, Bulgaria). Her scientific interests concern in the field of anthropology of childhood, children plays, and the everyday life culture during the communist period in Bulgaria. She is the author of three monographs: Images and Meetings in the Tradition, They Recognized him by his Name: Ethno-confessional Aspects of the Given Name in Bulgaria, and The Magic of the Given Name, as well as co-author of Almanac. Traditions and Holidays of the Bulgarians. She has co-edited several volumes, the last of which is Sociocultural Dimensions of Childhood (Sofia 2020)
Erken Sönen Güneş Işığı: Şair Petya Dubarova‘nın Hüzünlü Hikayesi
No full textÖz: Bulgar edebiyatının en yetenekli, en genç ve en ünlü temsilcilerinden biri olan Petya Dubarova Türkiye’de pek tanınmayan bir şairdır. Bu nedenle bu araştırmanın öncelikli amacı Bulgar yazarı Türk okuyucularına ve bilim dünyasına tanıtmaktır. Haksızlıklar ve adaletsizlik karşısında dik durduğu için Petya dünyayı çok erken terk etmiş. Muhteşem yeteneğini sonuna kadar ortaya çıkarmadan ve belki de en güzel şiirlerini kaleme almadan daha 17 yaşında intihar ederek yaşama veda etmiştir. Bu araştırmada Dubarova’nın renkli ve hüzünlü hayat hikâyesi büyüteç altına alınmış, ayrıca hem “Öğrenci Petya”nın hem de “Şair Petya”nın portresi resmedilmeye çalışılmıştır. Araştırmanın özeğinde Petya’nın öz yaşamı, romantik aşkları, öğrencilik yılları, yaşadığı kişisel sorunlar ve yazarlık yeteneği yer almaktadır. Petya Dubarova Bulgaristan’ın unutulamayan, henüz çocuk yaşta olağanüstü yeteneğiyle dikkat çeken şairlerinden biridir. Onun şiirsel kalıtı genellikle çocuksu arılığı, ergenlik yürekliliğini, felsefi sorgulamaları ve müthiş yaratıcılığı yansıtmaktadır. Dubarova geride yüzlerce yanıtsız soru bırakarak, çok genç yaşta yaşamına son vererek bizlerden ayrılmıştır. Kısa yaşamında bizi şaşırtmayı başarmış, ne var ki muazzam yeteneğinin yalnızca küçük bir ipucu vermiştir bizlere. Yaşamında da ölümünden sonra da bu genç yetenek tam olarak kavranamamış ve çevresindeki gizemli bulut da bir türlü çözülememiştir. Türk okuyucuları çocuk yaştaki bu yazarı pek bilmedikleri için hüzünlü yaşam serüvenini ve ozan olarak başarılarını bir makalede irdelemenin yararlı olacağı düşünülmüştür. Bu araştırmanın, Bulgar edebiyatı alanında ülkemizde önemli bir yayın boşluğunu doldurması umut edilmektedir.As one of the most talented, youngest, and renowned writers of Bulgaria, Petya Dubarova is a poet relatively unknown in Türkiye. Therefore, the primary purpose of this study is to introduce the Bulgarian author to the Turkish readers and the academic world. Petya departed this world way too prematurely because she confronted and resisted against the injustice and unfairness. Without revealing her amazing talent to the fullest and perhaps without writing her most beautiful poems, she bid farewell to the world by committing suicide at the age of 17. The present study focused on the colorful and sad life story of Dubarova, and the portrait of both the "Student Petya" and "Poet Petya" was depicted. The crux of this study includes Petya's personal life, her romantic affairs, her years as a student, her personal problems and her talent as a writer. Petya Dubarova is one of Bulgaria's most memorable and mystifying talented juvenile poets. Her poetic legacy often reflects childlike innocence, adolescent chivalry, philosophical inquiry and unearthly creativity. Dubarova departed this world, leaving behind hundreds of unanswered questions and ending her life at a very young age. She really managed to mystify us in her very short span of life and more importantly, demonstrated us only a small hint of her enormous talent. This young talent failed to be fully appreciated during her life or after her death, and the mystery around her could not be identified. Since Turkish readers are mostly unfamiliar with this tender- age writer, we are of the opinion that it will be worth of while to investigate her sad life adventure and her achievements as a poet in an article. It is believed that this study will fill an important scientific publication gap in Turkey in the field of Bulgarian literature
Genotyping of CYP3A5 polymorphisms among Bulgarian patients with sporadic colorectal cancer and controls
No full textBackground: The purpose of the study was to genotype four polymorphisms in CYP3A5 (CYP3A5 2, CYP3A5 3, CYP3A5 3B, and CYP3A5 6) for a possible association between individual genetic variations and susceptibility to colorectal cancer. Another point of interest was to conduct a comprehensive analysis in tumor and normal intestine tissue from the same patient, searching for somatic hotspots. Material and Methods: In our study, 146 Bulgarian patients with sporadic colorectal cancer and 160 healthy volunteers were enrolled. CYP3A5 polymorphisms were identified using rapid-cycle real-time amplification with allele-specific probes and subsequent melting curve analysis on a LightCycler (TM). Results: The allele frequencies were comparable in both groups: frequency of CYP3A5 2 = 0.3% in patients vs. 0.6% in controls; frequency of CYP3A5 3 = 90.8% in patients vs. 93.1% in controls; in both groups no CYP3A5 3B and CYP3A5 6 variants were detected (p > 0.05). No difference was observed between genotype frequencies in tumor and surrounding normal tissues of 80 patients. Conclusions: The CYP3A5 variants are unlikely to have an important functional significance in patients with colorectal cancer. The studied CYP3A5 loci do not seem to be hotspots for somatic mutation. DNA from archived tumor tissues is a valid alternative to the use of leukocyte DNA for genotyping of these polymorphisms
No association between MDR1 (ABCB1) 2677G > T and 3435C > T polymorphism and sporadic colorectal cancer among Bulgarian patients
No full textPurpose Variation in genetic factors together with xenobiotic exposure may result in increased risk of colorectal cancer. The P-glycoprotein (P-gp) is highly expressed in the apical membrane of enterocytes, where it pumps xenobiotics from the enterocytes back into the intestinal lumen. Thus, polymorphisms that reduce the activity of the MDR1 (ABCB1) efflux pump are potential risk factors for colorectal carcinogenesis. The aim of the present study is to genotype the MDR1 2677G > T (rs2032582) and 3435C > T (rs1045642) polymorphism in patients with colorectal cancer and controls and to identify a possible association between individual genetic variation and susceptibility to colorectal cancer. Methods In the present study, 146 Bulgarian patients with sporadic colorectal cancer and 160 healthy Bulgarian volunteers were evaluated for the two polymorphisms in MDR1. Polymorphisms were identified using rapid-cycle real-time amplification with allele-specific probes and subsequent melting curve analyses on a LightCycler (TM) (Roche Diagnostics, Mannheim, Germany). Results No differences were found between the frequencies of the two mutant alleles in the tumor tissue from the cases and lymphocytes from the controls [frequencies of 2677T: 43.5% in patients and 44.1% in controls; frequencies of 3435T: 48.3% in patients and 50.9% in controls (both P > 0.05)]. The MDR1 polymorphic sequence of the tumor tissue always matched that of normal intestinal tissue from the same patient. Consequently, genotyping of DNA from archived tumor tissues is a valid alternative to the use of leukocyte DNA. ConclusionsThe present study suggests that MDR1 2677G > T and 3435C > T polymorphism is not a risk factor for sporadic colon cancer among Bulgarians and that somatic mutation at these sites is not involved in the genesis of colon tumors. Further examination using larger number of samples must be necessary to reach to more reliable conclusions
NON-STEROIDAL ANTI-INFLAMMATORY DRUGS FOR TOPICAL OPHTHALMIC ADMINISTRATION: CONTEMPORARY TRENDS
Get PDFTopically applied drugs for the treatment of ocular inflammation are the most commonly used formulations due to many reasons: they are simple to use; they can be applied often and provide a high drug concentration; systemic side effects which are associated with oral administration can be avoided. But due to the physiological limitations of the eyes only a small number of anti-inflammatory agents, which have certain physico-chemical properties can be included in appropriate and efficient formulations for treatment of ocular inflammation. To prepare the optimal therapeutic and technological ophthalmic formulation, it is required to know the possibility of enhancing the bioavailability in the ocular tissues and to increase the therapeutic activity of the active substance, by using appropriate technological approaches to create a stable, tolerable and effective ophthalmic drug formulation. In this review, we focus on microemulsions, polymeric NPs, liposomes, SLNs, and nanosuspensions as formulations incorporating non-steroidal anti-inflammatory drugs (NSAIDs) for topical ophthalmic application.Â
Petya parent - "socialist" fatherhood in Mladý svět magazine at the end of the 70th and beginning of the 80s of the 20th century
Get PDFBc. Kateřina Vlčková ABSTRACT: Petya parent - "socialist" fatherhood in Mladý svět magazine at the end of the 70th and beginning of the 80s of the 20th century The topic of my thesis is fatherhood in socialist Czechoslovakia in the late 70s and 80s of the 20th century. My primary source research is a section Péťa Parent, published from 1979 to 1982 in the Mladý svět magazine. The uniqueness of this column, I see in the fact that the author (Petr Hora-Hořejš) as the father advise to "public" readers regarding about education and child care. The theoretical part will focus on the concepts that are relevant to my research, such as the gender culture, fatherhood, masculinity, private and public sphere, motherhood, femininity, etc. Among the basic questions I'll ask include the following: How "socialist" father defends and publishes his paternal role, how he views care and education (his) child or what image of man-father Mladý svět magazine helps to create. With my work I try to contribute to a greater awareness of the history of fatherhood changes and involvement father in a family area, which was at that time primarily attributed to the women-mothers
Erratum to: The political economy of adult learning systems
No full textIn the Editorial of this issue, Miroslav Stefanik was accidentally stated as the single author of the article “Multi-layered Perspective on the Barriers to Learning Participation of Disadvantaged Adults”. The article is a joint authorship by Sofie Cabus, Petya Ilieva-Trichkova and Miroslav Stefani
Catalytic Oxidation of CO and Benzene over Metal Nanoparticles Loaded on Hierarchical MFI Zeolite
No full textIn order to obtain highly active catalytic materials for oxidation of carbon monoxide and volatile organic compounds (VOCs), monometallic platinum, copper, and palladium catalysts were prepared by using of two types of ZSM-5 zeolite as supports—parent ZSM-5 and the same one treated by HF and NH4F buffer solution. The catalyst samples, obtained by loading of platinum, palladium, and copper on ZSM-5 zeolite treated using HF and NH4F buffer solution, were more active in the reaction of CO and benzene oxidation compared with catalyst samples containing untreated zeolite. The presence of secondary mesoporosity played a positive role in increasing the catalytic activity due to improved reactant diffusion. The only exception was the copper catalysts in the reaction of CO oxidation, in which case the catalyst, based on untreated ZSM-5 zeolite, was more active. In this specific case, the key role is played by the oxidative state of copper species loaded on the ZSM-5 zeolites
Does overproduction of chaperone proteins favour the repair of DNA injuries induced by oxidative stress? (Mini review)
No full textGenotype resistance to oxidative stress, induced by various physical/chemical stimuli has been the focus of scientists for the last decades, with several aspects – ecological (the formation of the genetic elite of population), agricultural and medical (radio-chemotherapy). Genotype resistance to oxidative stress is regarded as the integration of different morphological, physiological, biochemical, metabolic and genetic characteristics. Currently, it is supposed that the mechanisms involved in the formation of genotype resistance to oxidative stress are inter-correlated and inter-dependent, comprising changes in genes, proteins, enzymes, different metabolic pathways and/or biological networks. According to the present state of knowledge, various cellular targets, resulting in genotoxic stress, induction of DNA damage, mutations, genomic instability or apoptosis can trigger different signal transduction pathways, activating DNA repair, antioxidant and chaperone defence systems. Till now, a lot of experimental data have been accumulated concerning the contribution of DNA repair to the formation of genotype resistance to oxidative stress. At the same time, genotype resistance of organisms is largely determined by the ability of molecular chaperones to maintain conformational homeostasis of proteins (folding – misfolding – refolding or aggregation – degradation). The role of chaperones in protein homeostasis and cell death, especially in apoptosis, is well discussed in literature, but much less is known about their function in DNA repair. In this regard, here we addressed the question of whether the overproduction of chaperone proteins contributes to the repair of DNA damage caused by oxidative stress
Specifics in the Contemporary Development of Hotel Business in Bulgaria
No full textThe author analyses the numerical alteration of the number of hotels in Bulgaria in the recent years, the current specifics and problems in the hotel business. The correlations between this alteration and the number of fulfilled night-stays, the increase rate of the lodging base and the correspondence to the alterations in the employment in it. The dynamics in the development of the hotel business is examined in a territorial section and regarding the criteria “hotel category”. The author puts an emphasis on the factors that hamper the hotel business, the current requirements and trends. On this ground general conclusions are made and some recommendations on the utilization of the existing potential of the hotel business in Bulgaria are made.
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