1,633 research outputs found
Development of TD Website and Repository
Get PDFSEAFDEC, an Inter-Governmental Organization plays an important role in promotion of sustainable development of fisheries and aquaculture in the Southeast Asian Region for more than four decades. Cooperation with other regional and international organizations have been recognized through several important events such as Millennium Conference in 2001 and ASEAN-SEAFDEC Conference in 2011. Since 1990s, internet have been introduced worldwide, where information technology becomes important as a part of human life including education, economic, social and politicsand so on. Development of high speed internet creates a new communication system and support living style including works and activities such as public relations, multi-media production, publication etc., especially information dissemination and website which are technologies for communication between internal and external organization as well as in developing management system for efficiencies. The objective of this paper is to enhance SEAFDEC visibility by developing the information and dissemination system which developed new TD website in 2017.
In this regards, TD established Southeast Asian Fisheries Development Center, Training Department Institutional Repository (STIR), which is the official digital repository of scholarly, research and technical information of the Department to download all information materials using open source software named the DSpace.
In this paper, author considers the importance of information technology for introducing SEAFDEC/TD activities and improving access to SEAFDEC/TD technical/scientific articles was expressed via the website. In this regards, the author introduced for developing of the TD website and Repository to increase public relation and increase TD’s visibility as well as point out constrains of its development that requires the strengthening and cooperation within the Training Department of SEAFDEC
Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells.
Get PDFAlterations in DNA methylation are important in cancer, but the acquisition of these alterations is poorly understood. Using an unbiased global screen for CpG island methylation events, we have identified a non-random pattern of DNA hypermethylation acquired in p16-repressed cells. Interestingly, this pattern included loci located upstream of a number of homeobox genes. Upon removal of p16(INK4A) activity in primary human mammary epithelial cells, polycomb repressors, EZH2 and SUZ12, are up-regulated and recruited to HOXA9, a locus expressed during normal breast development and epigenetically silenced in breast cancer. We demonstrate that at this targeted locus, the up-regulation of polycomb repressors is accompanied by the recruitment of DNA methyltransferases and the hypermethylation of DNA, an endpoint, which we show to be dependent on SUZ12 expression. These results demonstrate a causal role of p16(INK4A) disruption in modulating DNA hypermethylation, and identify a dynamic and active process whereby epigenetic modulation of gene expression is activated as an early event in breast tumor progression
Identification of human papillomavirus DNA in cutaneous lesions of Cowden syndrome
Get PDFBackground: Cowden syndrome (CS) or multiple hamartoma syndrome is a cancer-associated genodermatosis inherited in an autosomal dominant pattern. One of the diagnostic criteria is facial papules which are felt to be trichilemmomas, benign hair follicle tumors, which some consider to be induced by human papillomavirus (HPV). Objective: To search for HPV in skin tumors, especially trichilemmomas, from patients with CS. Methods: Skin lesions from patients with CS were classified histologically. Each tumor was then analyzed for HPV DNA by polymerase chain reaction with different primer sets; positive amplicons were typed by direct sequencing. Results: Twenty-nine biopsies from 7 patients with CS were investigated. Only 2 of 29 tumors clinically suspected of being trichilemmomas were confirmed histologically. In addition, 3 sclerotic fibromas, also typical of CS, were found, as well as 1 sebaceous hyperplasia. The other 23 lesions showed histological features of HPV-induced tumors in various stages of development. HPV DNA was found in 19 of 29 cutaneous lesions. Tumors without any histological signs of HPV induction were negative for HPV DNA. Two tumors which were histologically classified as common warts contained HPV types 27 and 28. All the 17 other HPV types belong to the group of epidermodysplasia-verruciformis-associated types. Conclusions: The majority of cutaneous lesions in CS contain HPV DNA. They may have a variety of histological patterns. Trichilemmomas are not clinically distinctive and can be difficult to identify in CS patients. Copyright (C) 2003 S. Karger AG, Basel
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