285 research outputs found

    First person – Varun Jayeshkumar Shah

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    ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Varun Jayeshkumar Shah is the first author on ‘CRL7SMU1 E3 ligase complex-driven H2B ubiquitination functions in sister chromatid cohesion by regulating SMC1 expression’, published in Journal of Cell Science. Varun is a PhD student in the lab of Dr Subbareddy Maddika at the Centre for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad, India, investigating the role of LisH-domain-containing proteins in the assembly of multi-subunit E3 ligase complexes.</jats:p

    VARUN (CRATAEVA NURVALA BUCH-HAM): A CRITICAL REVIEW W.S.R. TO URINARY TRACT DISORDER

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    Human passion on herbal medicine dated back to times immemorial. Man is the clever living being that knows how to adapt to the changing environment of time and space. As we are all aware, the very survival of animal kingdom is depending on the plant kingdom. The plants or herbs played major part in the pharmaco therapy during the Vedic period in India. Vedic literatures indicate mainly about the utility of single herbs in management of common disease. Among all the single herbs one of the most valuable medicinal herb Varun (Crataeva nurvala Buch-Ham), which is used to treat the different disease and also maintain the healthy condition of the body system. It is a small tree having much branches belonging to family Capparidaceae. Each part of   Varun tree including bark, root, leaf having certain medicinal properties. Chiefly, the bark of   Varun mainly used in the treatment of urolithiasis (Asmari bhedan), the decoction of root bark mainly used in lymph adenitis (Gandamala nasan) and immature wound healing (Apakwa vidradhi) respectively. The leaf is mainly used to reduce the fattiness of the body (Medohar). Hence this paper work is prepared for the re-evolution of the therapeutic importance of the herbal plant Varun (Crataeva nurvala Buch-Ham).

    Social rights and economics : claims to health care and education in developing countries

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    The author analyzes contemporary rights-based and economic approaches to health care and education in developing countries. He assesses the foundations and uses of social rights in development, outlines an economic approach to improving health and education services, and then highlights the differences, similarities, and the hard questions that the economic critique poses for rights. The author argues that the policy consequences of rights overlap considerably with a modern economic approach. Both the rights-based and the economic approaches are skeptical that electoral politics and de facto market rules provide sufficient accountability for the effective and equitable provision of health and education services, and that further intrasectoral reforms in governance, particularly those that strengthen the hand of service recipients, are needed. There remain differences between the two approaches. Whether procedures for service delivery are ends in themselves, the degree of disaggregation at which outcomes should be assessed, the consequences of long-term deprivation, metrics used for making tradeoffs, and the behavioral distortions that result from subsidies are all areas where the approaches diverge. Even here, however, the differences are not irreconcilable, and advocates of the approaches need not regard each other as antagonists.Health Monitoring&Evaluation,Health Systems Development&Reform,Decentralization,Public Health Promotion,Early Child and Children's Health,Health Monitoring&Evaluation,Health Economics&Finance,Poverty Assessment,Agricultural Knowledge&Information Systems,Gender and Education

    Coherency matrices for characterization of vector optical fields

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    We describe optical coherency matrices as a generalized method for characterizing the statistical properties of optical fields. We then use this formalism to classify optical fields, in terms of separability, and transfer of entropy between multiple degrees of freedom.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2021-12-01The student, Varun Ajit Kelkar, accepted the attached license on 2019-07-12 at 20:22.The student, Varun Ajit Kelkar, submitted this Thesis for approval on 2019-07-12 at 20:30.This Thesis was approved for publication on 2019-07-15 at 11:29.DSpace SAF Submission Ingestion Package generated from Vireo submission #14293 on 2020-02-28 at 17:34:54Made available in DSpace on 2020-03-02T22:28:39Z (GMT). No. of bitstreams: 2 KELKAR-THESIS-2019.pdf: 4186432 bytes, checksum: 76f620553ecb37c57e32127e822013f7 (MD5) LICENSE.txt: 4214 bytes, checksum: 6693dea403ebef44d3e09913c73b4e94 (MD5) Previous issue date: 2019-07-15Embargo set by: Seth Robbins for item 113953 Lift date: 2022-03-02T22:28:46Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 113953 Lift date: 2022-03-02T22:38:05Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 113953 Lift date: 2022-03-02T22:39:04Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemLimited Restriction Lifted for Item 113953 on 2022-03-03T10:15:30Z

    Determination of structural changes and phase transformations in boron carbide by static and dynamic studies

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    Recent transmission electron microscopy results demonstrate that the failure of B4C is commensurate with the segregation of boron icosahedra embedded in amorphous carbon in 2–3 nm wide amorphous bands along the (113) lattice direction, in good agreement with our recent theoretical results. Boron carbide is generally composed of multiple polytypes of B4C which have the same primitive lattice parameters but differ from each other by the location of the boron and carbon atoms in the unit cells. The unit cells are formed by a 12-atom B12-nCn icosahedron and a 3-atom (C3-nBn) chain. Our theoretical results indicate that one polytype, B12(C3), whose formation is responsible for the failure of the entire material. This anomalous and poorly understood glass-like behavior in boron carbide has been the subject of research since its discovery over 70 years ago. The characterization of disorder in hot pressed and powder boron carbide samples is therefore of primary interest. The research work has focused on characterization techniques which can be used at a micrometric sampling size so that individual powder grains of the material can be utilized. Specifically, micro-Raman and electrical conductivity measurements can be used with micrometric gap cells to understand the disorder in B4C.The results also demonstrate that it is possible to induce transformations in boron carbide using electric fields that are comparable with those obtained under shock and nanoindentation. Our calculations present a hypothesis which can provide a solution to prevent the premature failure of B4C. A route to achieve suppression of the B12(CCC) polytype without significantly affecting the elastic constants is via low concentration Silicon (Si) doping of B4C. Suppression of B12(CCC) by Si doping has implications towards development of boron carbide armor with improved properties for protection against high velocity threats. In order to achieve this, nanostructures (nanowires, nanorods, etc.) of Sidoped boron carbide have been synthesized using a Solid-Liquid-Solid (SLS) growth mechanism. The resulting structures have been characterized by SEM, TEM and Raman spectroscopy and consolidated to evaluate their mechanical properties. In addition, the application of nanowires in a transparent and thermally conducting nanocomposite is demonstrated.Ph.D.Includes abstractVitaIncludes bibliographical referencesby Varun Gupt

    Multi-objective optimisation of web business processes

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    This paper proposes an approach for the optimisation of web business processes using multi-objective evolutionary computing. Business process optimisation is considered as the problem of constructing feasible business process designs with optimum attribute values such as duration and cost. This optimisation framework involves the application of a series of Evolutionary Multi-objective Optimisation Algorithms (EMOAs) in an attempt to generate a series of diverse optimised business process designs for given requirements. The optimisation framework is tested to validate the framework's capability in capturing, composing and optimising business process designs constituted of web services. The results from the web business process optimisation scenario, featured in this paper, demonstrate that the framework can identify business process designs with optimised attribute values

    Smart Cities in India:A Bibliometric Analysis

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    Smart cities have attained global popularity in the last decade. The present study attempts to find the trends of smart city research in India by exploring existing literature on this theme. Year-wise, author-wise, citation-wise, affiliation-wise, keywords-wise, country-wise and source-wise listing of literature are the parameters to conduct present study. Bibliometric method on Scopus database is employed. The research focus was determined by keyword co-occurrence using VOSviewer.</p

    An open-loop approach to study the stochastic properties

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    Randomness is an inevitable aspect of biological networks. It has been long accepted that variability of components in a network can propagate throughout the network. In this thesis, we introduce a method that allows us to decompose the total variability of a single component into individual contributions from the other components in a network. Our method of noise decomposition helps us investigate key parameters and their relative impact on the total normalized noise and also allows us to illustrate the importance of different system modifications by adding or omitting biological processes. With our generally applicable noise decomposition method, we are able to determine the strength of individual correlations induced by different co-regulation processes that connect different components of a network. In bistable systems, variability can occur through stochastic transitions from one steady state to another. Noise induced transitions between two steady states are difficult to calculate due to the intricate interplay between nonlinear dynamics and noise in bistable positive feedback loops. We open multicomponent feedback loops at the slowest variables in order to calculate the transition rates from one steady state to another. By reclosing the feedback loop, we calculate the mean first passage time (MFPT) using the Fokker-Planck equation. It is important to emphasize that the accurate approximation of the open-loop results is not a sufficient condition for a good prediction of the MFPT. We show that only the opening at the slowest variable warrants an accurate prediction of MFPT. Multiplicative interactions among different components can introduce correlations among noises. We show that the introduced correlations affect the mean and variance of the open loop function and consequently increase the transition rate between two steady states in the closed-loop system. Our results indicate that the open-loop approach can contribute to the theoretical prediction of the MFPT. The theoretical results are shown to be in good agreement with the results of stochastic simulation

    The Need for Continued Innovation in Solar, Wind, and Energy Storage

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    Varun Sivaram is the Philip D. Reed fellow for science and technology at the Council on Foreign Relations. He is also an adjunct professor at Georgetown University, an adjunct senior research scholar at Columbia University, and a member of the energy and environment advisory boards at Stanford University. He is the author of the book, Taming the Sun: Innovations to Harness Solar Energy and Power the Planet (MIT University Press, 2018) and the editor of the book, Digital Decarbonization: Promoting Clean Energy Systems Through Digital Innovations (CFR Press, 2018). Forbes named him one of its 30 under 30 in law and policy, and Grist named him one of the top 50 leaders in sustainability
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