196,197 research outputs found
Possible pathophysiological roles of transglutaminase - catalyzed reactions in the pathogenesis of human neurodegenerative diseases
No full textTransglutaminases (TG, E.C. 2.3.2.13) are related and ubiquitous enzymes that catalyze
the cross linking of a glutaminyl residue of a protein/peptide substrate to a lysyl residue of a
protein/peptide co-substrate. These enzymes are also capable of catalyzing other post-translational
reactions important for cell life. The distribution and the physiological roles of human TGs have
been widely studied in numerous cell types and tissues and recently their roles in several diseases
have begun to be identified. It has been hypothesized that transglutaminase activity is directly
involved in the pathogenetic mechanisms responsible for several human diseases. In particular, tissue
TG (tTG, TG2), a member of the TG enzyme family, has been recently shown to be involved in the
molecular mechanisms responsible for a very widespread human pathology, Celiac Disease (CD),
one of the most common food intolerances described in the western population. The main food agent
that provokes the strong and diffuse clinical symptoms has been known for several years to be
gliadin, a protein present in a very large number of human foods derived from vegetables. Recently,
some biochemical and immunological aspects of this very common disease have been clarified, and
“tissue” transglutaminase, a multifunctional and ubiquitous enzyme, has been identified as one of the
major factors. The aim of this review is to summarize the most recent findings concerning the
relationships between the biochemical properties of the transglutaminase activity and the basic
molecular mechanisms responsible for some human diseases, with particular reference to
neuropsychiatric disorders. Possible molecular links between CD and neuropsychiatric disorders, and
the use of transglutaminase inhibitors are also discussed
Sexual Counseling Improved Erectile Rehabilitation After Non-Nerve-Sparing Radical Retropubic Prostatectomy or Cystectomy—Results of a Randomized Prospective Study
No full textAim. The efficacy of prostaglandin E1 (PGE1)-intracavernous injection (ICI) therapy for erectile dysfunction (ED) after non-nerve-sparing (NNS) radical pelvic surgery depends on patient compliance. The purpose of this study was to verify the utility of sexual counseling in ICI in terms of treatment efficacy, compliance, and dropout rate.
Methods. In this prospective randomized study, 57 patients with ED after NNS radical prostatectomy or cystectomy were divided: 29 patients (group SC+) were treated with sexual counseling and PGE1-ICI therapy; the others 28 (group SC–) were treated with only ICI. At the start of the study all patients were administered the International Index of Erectile Function (IIEF) questionnaire and ICI training test; follow-up (at 3, 6, 9, 12, 18 months) was achieved by home Sildenafil test and ambulatory IIEF test; sexual counseling was provided only to group SC+.
Results. The mean IIEF score at the end of study was 26.5 (SC+) vs. 24.3 (SC–) (P < 0.05); eight patients (SC+, 27.5%) became responders to home Sildenafil vs. five (SC–, 17.8%) (P < 0.05); no dropout cases occurred (SC+) vs. eight (SC–, 28.5%) (P < 0.05). Moreover, we recorded best IIEF scores in group SC+ in sexual satisfaction (P < 0.05), sexual desire (P < 0.05), orgasmic function, and general satisfaction. Mean PGE1 doses were better in group SC+ (P < 0.05). ICI-oriented sexual counseling was utilized to motivate couples, to improve sexual intercourses, to correct mistakes in ICI administration. At the end of follow-up 21 patients (SC+) declared themselves satisfied vs. 12 (SC–).
Conclusions. ICI-oriented sexual counseling in ICI increased the efficacy of treatment, the compliance, and Sildenafil responders rate, decreased the dropout rate. Titta M, Tavolini IM, Dal Moro F, Cisternino A, and Bassi P. Sexual counseling improved erectile rehabilitation after non-nerve-sparing radical retropubic prostatectomy or cystectomy—results of a randomized prospective study
La diagnostica urologica delle disfunzione erettile. In Foresta C, Scandellari C: La disfunzione erettile. sintomo o malattia?
No full text
Riabilitazione erettile con approccio integrato androsessuologico in pazienti sottoposti a chirurgia pelvica maggiore non nerve-sparing
No full textDr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
Sex hormone changes in post-menopausal women with primary biliary cirrhosis (PBC) and with cryptogenic chronic liver disease.
No full textSex hormones and sex hormone binding globulin (SHBG) have been studied in 32 female post-menopausal patients (16 with Primary Biliary Cirrhosis (PBC) and 16 with cryptogenic chronic liver disease (CLD). Dehydroepiandrosterone-sulfate (DHEA-S) serum levels were significantly higher in PBC compared to CLD subjects (p less than 0.005). In PBC DHEA-S concentration was higher in precirrhotic than in cirrhotic patients (p less than 0.02). SHBG was raised in both PBC and CLD patients but higher in CLD compared to PBC subjects (p less than 0.002). PBC reveals a sex hormone pattern similar to post-menopausal subjects with breast cancer. These results suggest that sex hormone alteration is present in females with different types of liver disease, but the metabolic pattern is not due to liver disease per se
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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