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    Combined treatment of ureteropelvic junction obstruction and renal calculi with robot-assisted laparoscopic pyeloplasty and laser lithotripsy in children: Case report and non-systematic review of the literature

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    Objective(s): The incidence of urinary tract stone disease is steadily increasing in both adult and paediatric populations. This condition develops due to different factors: dietary or metabolic alterations, infection, and congenital anatomic malformations. Standard indications and treatments for children are analogous to the ones indicated for adults. Extracorporeal shock wave lithotripsy, ureterorenoscopy and percutaneous nephrolithotomy (PCNL) should be preferred to more invasive techniques. Moreover, the introduction of laparoscopic and robot-assisted laparoscopic approaches have improved surgical outcomes, lowering the bleeding risk with higher stone-free rates, even in complicated cases. Despite these well-known improvements, there are few reports regarding laparoscopic robot-assisted management for urinary tract stone disease in paediatric patients under the age of 10, especially with concomitant treatment of ureteropelvic junction obstruction and multiple calyceal stones. Patient and Method(s): A 4-year-old child was referred for recurrent right abdominal flank pain, macroscopic haematuria and a previous history of urinary tract infections. A computed tomography of the abdomen showed right ureteropelvic junction obstruction associated with multiple unilateral stones located in the renal pelvis and in the interpolar renal calyces. Due to its complexity, we held a multidisciplinary meeting with paediatric surgeons and nephrologists to determine optimal treatment. As a result, a combined robot-assisted laparoscopic pyeloplasty (LP) and renal calculi holmium laser lithotripsy using a digital flexible ureteroscope through an abdominal robotic trocar was performed. No post-surgical complications were recorded, and the patient was discharged within 48 h following surgery. At subsequent regular follow-up examinations over a period of 24 months, no signs of recurrence were detected for both ureteropelvic junction obstruction and stone disease. Result(s): Robot-assisted LP with concomitant laser lithotripsy is a reasonable treatment option for designated young paediatric patients with challenging ureteropelvic junction obstruction complicated by urolithiasis, especially in cases where stones are not amenable with standard procedures

    Biopsy of the anterior prostate gland: technique with end-fire transrectal ultrasound.

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    OBJECTIVES: Transperineal approach is considered the best method to biopsy the anterior tissue of the prostate gland that is generally neglected by transrectal approach. We describe a technique of anterior prostate biopsy obtained with transrectal approach using an end-fire probe. MATERIALS AND METHODS: We correlated the images of the video of the diagnostic biopsy, the histology of the biopsy and of the surgical specimen after radical prostatectomy. A 68 years old may previously underwent two biopsies: first biopsy and re-biopsy were performed using the transrectal approach with 12 and 16 cores respectively, including the tranisizion zone (2 per side). Initial histology revealed high grade PIN only. We performed a saturation biopsy (28 samples) under local anesthesia, as outpatient, using endfire ultrasound probe, including anterior zone and fibromuscolar stroma (2 per side). Images of the procedure was stored electronically. Each biopsy core was pre-embedded and inked at one side in order to identify the rectal end (pericapsular side). Surgical specimen of radical nerve sparing prostatectomy was analyzed according to the Stanford protocol (3 mm). All biopsies and surgical specimens were reviewed by the same uro-pathologist. RESULTS: Cancer was detected only by anterior biopsy (left side, 1 core, 3 mm of total cancer extension, Gleason score 3 + 3, placed into the not inked core side). Histology of the surgical specimen confirmed the location of the disease with 0.3 cc tumor volume. Technically, to improve biopsy of the anterior zone the tip of the needle should obtain all the tissue up to the Santorini venous plexus. Postoperative recovery was uneventful after both procedures. CONCLUSION: We showed that end-fire probe makes possible, effective and safe the biopsy of the anterior prostate, which may contain cancer in particular when previous biopsies are negative. The anterior biopsy technique herein described is easy and reliable. Based on our experience, end-fire probe should be used in re-biopsy or saturation biopsy if transrectal approach is preferred. Confirmatory randomized clinical trial should be done in the future

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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