1,720,967 research outputs found
Clinical outcome of deep infiltrating colorectal endometriosis surgeries in the Endometriosis Center of the University of Gießen and Marburg between 2005-2015
Full text linkThe gold standard of treatment for colorectal endometriosis is the surgical removal of the lesion with shaving, disc excision or segmental colorectal resection. Which method is the most appropriate is controversial and clear criteria for the choice of surgery are missing. We conducted a retrospective cohort study of 120 patients, who underwent colorectal endometriosis surgery at the Endometriosis Center of the University of Gießen and Marburg between 2005 and 2015 in order to define clear criteria for each surgical modality and assess clinical outcome. We analysed the clinical records of the patients and answers of a self-developed questionnaire as well as telephone interviews.
75 patients underwent segmental colorectal resection, 19 disc excision and 26 shaving. The mean age of the patients was 34 years. 78% of the patients suffered from pain symptoms and 58% had a pregnancy wish. The surgery lasted an average of 292 minutes with a mean hospital stay of 5, 6 and 7 days after shaving, disc excision and segmental resection, respectively. The bowel lesion was associated in every second patient with endometriosis of the ovaries and in every third patient with infiltration of the vagina, rectovaginal space, sacrouterine ligaments and pelvic side walls. The majority of the bowel lesions in the shaving procedures measured up to 3cm and infiltrated the serosa and subserosa. With disc excision mainly lesions between 3-6cm with muscularis layer infiltration were removed. In the segmental resection group every third patient had multifocal, long segment affection of the bowel wall and 10% multicenter lesions with 2-3 nodules. The lesions infiltrated at least the muscularis and in 25% and 7% the submucosa and mucosa, respectively. All procedures improved significantly the pain symptoms, bowel dysfunctions and libido as well as the reproductive results. The pregnancy and delivery rates revealed 57% and 39%, respectively. Two patients underwent a severe labour complication with rupture of the posterior uterine and vaginal vault. We observed a histological recurrence of endometriosis in 9% of the patients, having one patient both in the disc excision and shaving group with recurrence of bowel endometriosis. Recurrence of bowel endometriosis did not occur after segmental resection. The segmental resection was associated with the highest intra- and postoperative complication rates having an injury of the ureter and anastomotic leakage.
We can conclude that none of the procedures are superior to the other one regarding clinical outcome. Small superficial lesions should be removed with shaving. Singular nodules with muscular infiltration are appropriate for disc excision. Lesions with multifocal or multicentre character, or isolated nodules with infiltration up to the mucosa and significant bowel circumference involvement should be treated with segmental colorectal resection
Untersuchungen zum Beckenbindegewebe der Frau unter besonderer Berücksichtigung des Halteapparates und des Gefäßsystems des Uterus und der Urethra - klinische und funktionelle Aspekte, Immunhistochemie und Elektronenmikroskopie
Full text linkBei der Entwicklung eines Deszensus bzw. Prolaps uteri und einer Belastungsinkontinenz spielen Veränderungen im Bindegewebe eine entscheidende Rolle. In der vorliegenden Arbeit haben wir das Beckenbindegewebe bei Frauen mit Inkontinenz und Deszensus untersucht. Dabei konnten wir markante Unterschiede herausarbeiten. Wir fanden bei Patientinnen mit Prolaps uteri eine erniedrigte Konzentration von Kollagen und Elastin.Bei den Glykoproteinen zeigte sich eine auffällige Zunahme der Tenascintinktion. Bei Patientinnen mit Belastungsinkontinenz fanden wir eine Abnahme von Kollagen, Elastinsowie einen verminderten Nachweis des GlykoproteinsVitronektin. Unsere Befunde dokumentieren eindrucksvoll Bindegewebsveränderungen bei Patientinnen mit Beckenbodeninsuffizienz. Die Veränderungen im Fasersystem des Bindegewebes lassen eine entscheidende Rolle bei der Entwicklung eines Prolaps bzw. einer Belastungsinkontinenz vermuten und begründen möglicherweise neue Therapiekonzepte.Pelvic organ prolapse and genuine stress incontinence is accompanied by an altered composition of the extracellular matrix. To address this question, we analyzed the connective tissues of the sacrospinous ligament, the uterine artery wall and periurethral connective tissue of postmenopausal women with and without POP or incontinence. Greater amounts of tenascin and lesser amounts of collagen, elastin and vitronectin were therefore found in patients with Pelvic organ prolapse. Compared with the continent women, the tissue samples of the incontinent women showed a significantly weaker immunohistochemical staining of type I, III, and VI collagen. Intact vitronectinand elastin were found in the periurethral tissues of all the continent women, whereas vitronectin and elastin was absent in the incontinent women. Our results indicate an altered metabolism of connective tissue in the female pelvic floor with a significant decrease of collagen, elastin and vitronectin expression in women with prolapse and incontinence.von Christian Göpe
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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