2,843 research outputs found
R23. Demographics and Outcomes of Patients Hospitalized for COVID-19
No full textCorresponding author (University of Mississippi Medical Center): Jonathan T. Newbaker, [email protected]://egrove.olemiss.edu/pharm_annual_posters/1022/thumbnail.jp
Recombineering strategies for developing next generation BAC transgenic tools for optogenetics and beyond
No full textThe development and application of diverse BAC transgenic rodent lines has enabled rapid progress for precise molecular targeting of genetically-defined cell types in the mammalian central nervous system. These transgenic tools have played a central role in the optogenetic revolution in neuroscience. Indeed, an overwhelming proportion of studies in this field have made use of BAC transgenic Cre driver lines to achieve targeted expression of optogenetic probes in the brain. In addition, several BAC transgenic mouse lines have been established for direct cell-type specific expression of Channelrhodopsin-2 (ChR2). While the benefits of these new tools largely outweigh any accompanying challenges, many available BAC transgenic lines may suffer from confounds due in part to increased gene dosage of one or more “extra” genes contained within the large BAC DNA sequences. Here we discuss this under-appreciated issue and propose strategies for developing the next generation of BAC transgenic lines that are devoid of extra genes. Furthermore, we provide evidence that these strategies are simple, reproducible, and do not disrupt the intended cell-type specific transgene expression patterns for several distinct BAC clones. These strategies may be widely implemented for improved BAC transgenesis across diverse disciplines.Brain and Behavior Research Foundation (Young Investigator Award)National Institutes of Health (U.S.). Ruth L. Kirschstein National Research Service Award (F32-MH084460
Neurobiology of obsessive–compulsive disorder: insights into neural circuitry dysfunction through mouse genetics
No full textThe precise causal factors for obsessive–compulsive disorder (OCD) are not known, although, decades of research have honed in on the cortico-striatal-thalamo-cortical (CSTC) circuitry in the brain as a critical pathway involved in obsessions and the intimately linked compulsive–repetitive behaviors. Recent progress in human and mouse genetics have led to the identification of novel candidate susceptibility genes, which in turn have facilitated a more focused approach to unraveling the nature of circuitry dysfunction in OCD. The ability to perform invasive techniques in genetic animal models of OCD will be crucial for rapid advances in this field, and as such we review the most recent developments and highlight the importance of searching out common circuitry defects underlying compulsive–repetitive behaviors.National Institutes of Health (U.S.) (Grant NIMH R01MH081201)Hartwell FoundationSimons Foundation. Autism Research InitiativeStanley Center for Psychiatric ResearchBroad Institute of MIT and Harvard. SPARC ProgramBrain & Behavior Research Foundation (Young Investigator Award)National Institute of Mental Health (U.S.) (Ruth L. Kirschstein National Research Service Award F32MH084460
An answer to a paper, [electronic resource] : Called A Memorial Of the Poor Inhabitants, Tradesmen and Labourers of the Kingdom of Ireland. By the Author of the Short View of the State of Ireland.
No full textThe author of The short view = Jonathan Swift.An answer to 'To the R-d Dr. J-n S-t, the memorial .. ', by Sir John Browne.Teerink-Scouten,Hanson,Goldsmiths',Electronic reproduction.English Short Title Catalog,Reproduction of original from University of London's Goldsmiths' Library
Active suppression of the class II transactivator-encoding AIR-1 locus is responsible for the lack of major histocompatibility complex class II gene expression observed during differentiation from B cells to plasma cells.
No full textCited by the Following Articles in PubMed:
Han Chen, Carolyn A. Gilbert, John A. Hudson, Sophia C. Bolick, Kenneth L. Wright, and Janet F. Piskurich. Positive Regulatory Domain I-Binding Factor 1 mediates repression of the MHC Class II Transactivator (CIITA) type IV promoter. Mol Immunol. Author manuscript; available in PMC 2007 September 20. Published in final edited form as: Mol Immunol. 2007 February; 44(6): 1461–1470. Published online 2006 June 12. doi: 016/j.molimm.2006.04.026.
Jonathan A. Harton and Jenny P.-Y. Ting. Class II Transactivator: Mastering the Art of Major Histocompatibility Complex Expression.
Mol Cell Biol. 2000 September; 20(17): 6185–6194
Earthquake and tsunami impact analysis of five Oregon coastal communities
No full textReport -- Spreadsheet.by John M. Bauer, Jonathan C. Allan, Laura L. S. Gabel, Fletcher E. O'Brien, and Jed T. Roberts.Title from PDF cover (viewed on July 7, 2020).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references.Mode of access: Internet from the Oregon Government Publications Collection.Text in English
HLA class II expression in uninducible hepatocarcinoma cells after transfection of AIR-1 gene product CIITA. Acquisition of antigen processing and presentation capacity.
No full textCited in PubMed archive by:
Jonathan A. Harton and Jenny P.-Y. Ting. Class II Transactivator: Mastering the Art of Major Histocompatibility Complex Expression.
Mol Cell Biol. 2000 September; 20(17): 6185–6194
Le basi ontologiche e metafisiche della filosofia della mente. Essere e soggetto in Jonathan Lowe
No full textIn recent years analytic philosophy has shown a growing interest in ontology and metaphysics, through a path that has led to a clearer awareness of methods and aims of these disciplines. Today the fact that ontology and metaphysics fulfill the aims of determining what there is and why this is the case is generally accepted, but the meta-theoretical debate about their legitimacy, the way they relate to different scientific disciplines and, especially, their implications in other areas of research (primarily in logic and in philosophy of mind) are more controversial. Jonathan Lowe, metaphysician, ontologist and philosopher of mind, is a very active author in this debate. The purpose of these pages is to analyze and to discuss his main theses in metaphysics and ontology and their impact on philosophy of mind, especially as regards the mind-body relation and the ontological status of the subject
Paranoia and irony in the Anglophone dectective narrative and the novels of Umberto Eco
No full textThe thesis provides a reading of Umberto Eco's three novels, The Name of the
Rose, Foucault's Pendulum, and The Island of the Day Before, that, while it
acknowledges the importance of the Italian literary tradition in which they stand, also
seeks to explain why their author appeals so frequently to literary models outside
Italy, and in particular the Anglo-American detective genre.
Chapter One explains Eco's relationship to the development of Italian literature
through his lifetime. It is noted that Eco is beginning, both in his semiotics and his
fiction, from a position where post-structuralism has been extensively explored by
neo-avant-gardew riters. Eco positions himself alongsides uchw riters as Italo Calvino
and Jorge Luis Borges, who wish to explore the ludic possibilities of working within
structures, while all the time acknowledging the epistemological limitations of so
doing. Eco's chosen structure, more often than not, is the highly defined genre of
the detective story.
From here, the following chapters engage in close readings of the three novels,
with particular emphasis on The Name of the Rose and Foucault's Pendulum,
demonstrating that they explore problems of interpretation central to the detective
narrative. In doing this, they display an intimate knowledge of generic developments
within the detective tradition, and of the philosophical and aesthetic uses made of the
genre by other writers. The embedding of intertextual references to other detective
narratives within Eco's novels is an important factor, as they come together to form
a narrative of epistemological inquiry that itself follows Eco's philosophical progress
through the years. In short, the novels, inter alia, map a systematic inquiry into the
possibility of systematic inquiry. They reserve the space to engage in such an ironic
and self-referential project precisely through their fictionality
10-05 "The Macroeconomics of Development without Throughput Growth"
No full textSerious discussion has begun of policies to promote the goal of increasing well-being without material growth. Moving towards this goal requires a profound reorientation of macroeconomic theory. Importantly, the call by ecological economists to move away from traditional growth-oriented models comes at a moment when standard macroeconomics is in considerable turmoil. The financial crisis of 2008/2009 seriously undermined the basis for mainstream macroeconomics and brought renewed attention to various forms of Keynesian analysis and policy previously regarded as outdated. There is a close complementarity between new Keynesian and ecological perspectives. While older Keynesian analysis was oriented towards promoting growth, a true Keynesian analysis of the relationship between investment and consumption does not depend on a growth orientation. What this analysis has in common with an ecological perspective is the rejection of market optimality assumed in classical models. Moving away from the neoclassical goal of inter-temporal utility maximization allows for different, pluralistic economic goals: full employment, provision of basic needs, social and infrastructure investment, and income equity. These goals are compatible with environmental preservation and resource sustainability, whereas indefinite growth is not. But they require a revitalization of the sphere of social investment, seriously neglected (indeed often omitted completely) in standard models. Reintroducing this perspective allows the development of an economic theory suitable for the transition to a stable-population, low-carbon, resource-conserving global economy. The barriers to this transition are primarily political and institutional, not economic. Specifically, an eco-Keynesian perspective emphasizes new macroeconomic categories including: * human-capital-intensive services * investment in energy-conserving capital * investment in natural and human capital The expansion of these categories provides a basis for growth in wellbeing without growth in throughput, while preserving full employment and economic stability. This paper explores some of the implications of this altered macroeconomic perspective for development in both the global "North" and "South". It is suggested that the problems following the global financial crisis cannot be resolved by a return to traditional growth patterns, and will require large-scale practical policies based on eco-Keynesianism.
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