2,609 research outputs found
Why special relativity should not be a template for a fundamental reformulation of quantum mechanics
No full textIn a comparison of the principles of special relativity and of quantum mechanics, the former theory is marked by its relative economy and apparent explanatory simplicity. A number of theorists have thus been led to search for a small number of postulates - essentially information theoretic in nature - that would play the role in quantum mechanics that the relativity principle and the light postulate jointly play in Einstein's 1905 special relativity theory. The purpose of the present paper is to resist this idea, at least in so far as it is supposed to reveal the fundamental form of the theory. It is argued that the methodology of Einstein's 1905 theory represents a victory of pragmatism over explanatory depth; and that its adoption only made sense in the context of the chaotic state state of physics at the start of the 20th century - as Einstein well knew
Quantum Mechanics on Spacetime I: Spacetime State Realism
No full textWhat ontology does realism about the quantum state suggest? The main extant view in contemporary philosophy of physics is wave-function realism. We elaborate the sense in which wave-function realism does provide an ontological picture; and defend it from certain objections that have been raised against it. However, there are good reasons to be dissatisfied with wave-function realism, as we go on to elaborate. This motivates the development of an opposing picture: what we call spacetime state realism; a view which takes the states associated to spacetime regions as fundamental. This approach enjoys a number of beneficial features, although, unlike wave-function realism, it involves non-separability at the level of fundamental ontology. We investigate the pros and cons of this non-separability, arguing that it is a quite acceptable feature; even one which proves fruitful in the context of relativistic covariance. A companion paper discusses the prospects for combining a spacetime-based ontology with separability, along lines suggested by Deutsch and Hayde
"The 'fightin'est' Canadian general:" Brigadier Christopher Vokes and his approach to military command, June 1942 -- August 1943
No full textThis thesis evaluates the manner in which Brigadier Christopher Yokes dealt with the technical and human aspects of command while commanding the 2nd Canadian Infantry Brigade from 25 June 1942 until the end of the Sicilian campaign in August 1943. It seeks to promote a greater understanding of brigade-level command and to rehabilitate Vokes's reputation as a commander, which has largely been based on certain negative personality traits. The author argues that Yokes was a successful commander because he maintained a good balance between technical skills such as planning and directing operations and his ability to understand, motivate, and lead soldiers, and because his actions were guided by a sound philosophy of command based on personal leadership and teamwork. These elements allowed Christopher Yokes to train and lead a highly effective and cohesive fighting force that defeated some of Germany's best troops in the physically demanding environment of the Sicilian battlefield
"The 'fightin'est' Canadian general:" Brigadier Christopher Vokes and his approach to military command, June 1942 -- August 1943
No full textThis thesis evaluates the manner in which Brigadier Christopher Yokes dealt with the technical and human aspects of command while commanding the 2nd Canadian Infantry Brigade from 25 June 1942 until the end of the Sicilian campaign in August 1943. It seeks to promote a greater understanding of brigade-level command and to rehabilitate Vokes's reputation as a commander, which has largely been based on certain negative personality traits. The author argues that Yokes was a successful commander because he maintained a good balance between technical skills such as planning and directing operations and his ability to understand, motivate, and lead soldiers, and because his actions were guided by a sound philosophy of command based on personal leadership and teamwork. These elements allowed Christopher Yokes to train and lead a highly effective and cohesive fighting force that defeated some of Germany's best troops in the physically demanding environment of the Sicilian battlefield
Founders: Christopher Taylor
No full text\ua9 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. ‘Founders’ is an intermittent series of short, critical appreciations of scholars, researchers and others whose work and ideas, mainly in Britain, have made particularly sweeping, influential and foundational contributions to the development of historically- and archaeologically-informed landscape studies. This latest addition to the series concerns Christopher Taylor, whose death on 28th May 2021 was noted in the Landscapes editorial in issue 21.2
Pannexin-1 and P2X7-Receptor Are Required for Apoptotic Osteocytes in Fatigued Bone to Trigger RANKL Production in Neighboring Bystander Osteocytes
No full textOsteocyte apoptosis is required to induce intracortical bone remodeling after microdamage in animal models, but how apoptotic osteocytes signal neighboring “bystander” cells to initiate the remodeling process is unknown. Apoptosis has been shown to open pannexin-1 (Panx1) channels to release adenosine diphosphate (ATP) as a “find me” signal for phagocytic cells. To address whether apoptotic osteocytes use this signaling mechanism, we adapted the rat ulnar fatigue-loading model to reproducibly introduce microdamage into mouse cortical bone and measured subsequent changes in osteocyte apoptosis, receptor activator of NF-kB ligand (RANKL) expression and osteoclastic bone resorption in wild-type (WT; C57Bl/6) mice and in mice genetically deficient in Panx1 (Panx1KO). Mouse ulnar loading produced linear microcracks comparable in number and location to the rat model. WT mice showed increased osteocyte apoptosis and RANKL expression at microdamage sites at 3 days after loading and increased intracortical remodeling and endocortical tunneling at day 14. With fatigue, Panx1KO mice exhibited levels of microdamage and osteocyte apoptosis identical to WT mice. However, they did not upregulate RANKL in bystander osteocytes or initiate resorption. Panx1 interacts with P2X7R in ATP release; thus, we examined P2X7R-deficient mice and WT mice treated with P2X7R antagonist Brilliant Blue G (BBG) to test the possible role of ATP as a find-me signal. P2X7RKO mice failed to upregulate RANKL in osteocytes or induce resorption despite normally elevated osteocyte apoptosis after fatigue loading. Similarly, treatment of fatigued C57Bl/6 mice with BBG mimicked behavior of both Panx1 KO and P2X7RKO mice; BBG had no effect on osteocyte apoptosis in fatigued bone but completely prevented increases in bystander osteocyte RANKL expression and attenuated activation of resorption by more than 50%. These results indicate that activation of Panx1 and P2X7R are required for apoptotic osteocytes in fatigued bone to trigger RANKL production in neighboring bystander osteocytes and implicate ATP as an essential signal mediating this process.Peer reviewe
The effects of estrogen deficiency on cortical bone microporosity and mineralization
No full textRecent studies have demonstrated matrix-mineral alterations in bone tissue surrounding osteocytes in estrogen-deficient animals.While cortical bone porosity has been shown to be a contributor to the mechanical properties of bone tissue, little analysis has been done to investigate the effects of estrogen deficiency on bone's microporosities, including the vascular and osteocyte lacunar porosities. In this study we examined alterations in cortical bone microporosity, mineralization, and cancellous bone architecture due to estrogen deficiency in the ovariectomized rat model of postmenopausal osteoporosis. Twenty-week-old female Sprague–Dawley rats were subjected to either ovariectomy or sham surgery. Six weeks post-surgery tibiae were analyzed using high-resolution micro-CT, backscattered electron imaging, nanoindentation, and dynamic histomorphometry. Estrogen deficiency caused an increase in cortical bone vascular porosity, with enlarged vascular pores and little change in tissue mineral density in the proximal tibial metaphysis. Measurements of cancellous architecture corresponded to previous studies reporting a decrease in bone volume fraction, an increase in trabecular separation, and a decrease in trabecular number in the proximal tibia due to estrogen deficiency. Nanoindentation results showed no differences in matrix stiffness in osteocyte-rich areas of the proximal tibia of estrogen-deficient rats, and bone labeling and backscattered electron imaging showed no significant changes in mineralization around the vascular pores. The findings demonstrate local surface alterations of vascular pores due to estrogen deficiency. An increase in cortical vascular porosity may diminish bone strength as well as alter bone mechanotransduction via interstitial fluid flow, both of which could contribute to bone fragility during postmenopausal osteoporosis.Peer reviewe
Heritability and Linkage Analysis of Appendicitis Utilizing Age at Onset
No full textAppendicitis usually afflicts the young, but there is a large tail in the distribution of onset age. The genetics of this disease are still not well understood. A heritability analysis and genome wide linkage analysis of a large twin dataset was undertaken. Treating age of onset of appendicitis as a censored survival trait revealed a heritability of 0.21, and found evidence of linkage to Chromosome 1p37.3. Author(s): Christopher Oldmeadow 1 * | Kerrie Mengersen 2 | Nicholas Martin 3 | David L. Duffy
Quantum information theory and the foundations of quantum mechanics
No full textThis thesis is a contribution to the debate on the implications of quantum information theory for the foundational problems of quantum mechanics. In Part I an attempt is made to shed some light on the nature of information and quantum information theory. It is emphasized that the everyday notion of information is to be firmly distinguished from the technical notions arising in information theory; however it is maintained that in both settings ‘information’ functions as an abstract noun, hence does not refer to a particular or substance. The popular claim ‘Information is Physical’ is assessed and it is argued that this proposition faces a destructive dilemma. Accordingly, the slogan may not be understood as an ontological claim, but at best, as a methodological one. A novel argument is provided against Dretske’s (1981) attempt to base a semantic notion of information on ideas from information theory. The function of various measures of information content for quantum systems is explored and the applicability of the Shannon information in the quantum context maintained against the challenge of Brukner and Zeilinger (2001). The phenomenon of quantum teleportation is then explored as a case study serving to emphasize the value of recognising the logical status of ‘information’ as an abstract noun: it is argued that the conceptual puzzles often associated with this phenomenon result from the familiar error of hypostatizing an abstract noun. The approach of Deutsch and Hayden (2000) to the questions of locality and information flow in entangled quantum systems is assessed. It is suggested that the approach suffers from an equivocation between a conservative and an ontological reading; and the differing implications of each is examined. Some results are presented on the characterization of entanglement in the Deutsch-Hayden formalism. Part I closes with a discussion of some philosophical aspects of quantum computation. In particular, it is argued against Deutsch that the Church-Turing hypothesis is not underwritten by a physical principle, the Turing Principle. Some general morals are drawn concerning the nature of quantum information theory. In Part II, attention turns to the question of the implications of quantum information theory for our understanding of the meaning of the quantum formalism. Following some preliminary remarks, two particular information-theoretic approaches to the foundations of quantum mechanics are assessed in detail. It is argued that Zeilinger’s (1999) Foundational Principle is unsuccessful as a foundational principle for quantum mechanics. The information-theoretic characterization theorem of Clifton, Bub and Halvorson (2003) is assessed more favourably, but the generality of the approach is questioned and it is argued that the implications of the theorem for the traditional foundational problems in quantum mechanics remains obscure
Evaluation of transmission infrared spectroscopy and digital and optical refractometers to identify low immunoglobulin G concentrations in alpaca serum.
No full textThis study aimed to evaluate the digital Brix and optical serum total protein (STP) refractometers for measuring concentrations of serum immunoglobulin G (IgG) in alpacas and compare them to IgG concentrations measured by the reference method of radial immunodiffusion (RID) assay. The appropriate cutoff point for Brix and STP refractometers and the transmission infrared (TIR) spectroscopy method was determined for low IgG concentrations (< 10 g/L). Serum samples were collected from alpacas (N = 169) and tested by both refractometers. The correlation between Brix % and STP was high [correlation coefficient (r) = 0.99]. However, the correlation coefficients between Brix % and STP with serum RID-IgG concentrations were only 0.56 and 0.55, respectively. Twenty-one (12.4%) of 169 alpaca serum samples had IgG concentrations of < 10 g/L. Using receiver operator characteristic curve (ROC) analysis, the optimal cutoff points for the TIR assay, digital Brix, and optical STP refractometers for assessing low IgG (RID < 10 g/L) were 13 g/L, 8.8%, and 50 g/L, respectively. The TIR assay showed higher sensitivity (Se = 95.2%) and specificity (Sp = 96.8%) than either the digital Brix (Se = 90.5% and Sp = 65.5%) or optical STP (Se = 81% and Sp = 73.7%) refractometers for assessing alpacas with low IgG. In conclusion, the Brix and STP refractometers lack accuracy in measuring alpaca IgG concentrations, but may be useful for screening animals for low serum IgG. However, the TIR assay with a cutoff point of 13 g/L was more appropriate for identifying low IgG than either refractometer. Another study that focuses on neonatal crias is recommended in order to evaluate the usefulness of these assays for field diagnosing of failure of transfer of passive immunity (FTPI).journal article2017 Julimporte
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